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Cat.No. 1481 - (-)-5'-DMH-CBD | C25H38O2 | CAS No. 97452-63-6
Description: Metabolically stable anandamide transport inhibitor
Alternative Names: (-)-5'-Dimethylheptyl-cannabidiol
Chemical Name: 5-(1,1-Dimethylheptyl)-2-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-1,3-benzenediol

Biological Activity

Anandamide membrane transport inhibitor (IC50 = 14 μM) that is relatively metabolically stable. Displays some affinity for CB2 receptors but has only weak affinity for CB1 receptors and has no activity at VR1 receptors or FAAH. Anticonvulsive in vivo following systemic administration.

Technical Data

M. Wt 370.57
Formula C25H38O2
Storage Desiccate at -20°C
CAS Number 97452-63-6
PubChem ID 126670
Smiles C=[C@](C)[C@@H]1CCC(C)=C[C@H]1[C@]2=C(O)C=C(C(C)(C)CCCCCC)C=C2O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 5mg/ml)

Preparing Stock Solutions

The following data is based on the product molecular weight 370.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.7 mL 13.49 mL 26.99 mL
5 mM 0.54 mL 2.7 mL 5.4 mL
10 mM 0.27 mL 1.35 mL 2.7 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Bisogno et al (2001) Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide. Br.J.Pharmacol. 134 845 PMID: 11606325

Leite et al (1982) Anticonvulsant effects of the (-) and (+)isomers of cannabidiol and their dimethylheptyl homologs. Pharmacology 24 141 PMID: 7071126

If you know of a relevant reference for (-)-5'-DMH-CBD, please let us know.

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