Miglustat hydrochloride

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Cat.No. 3117 - Miglustat hydrochloride | C10H21NO4.HCl | CAS No. 210110-90-0
Description: α-glucosidase I and II inhibitor. Also inhibits ceramide-specific glycosyltransferases
Alternative Names: N-Butyldeoxynojirimycin hydrochloride, NB-DNJ
Chemical Name: (2R,3R,4R,5S)-1-Butyl-2-(hydroxymethyl)-3,4,5-piperidinetriol hydrochloride
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Orally active α-glucosidase I and II and ceramide-specific glycosyltransferase inhibitor. Rescues trafficking-deficient F508del-CFTR in human airway epithelial cells via inhibition of ER α-glucosidases I and II. Also has broad spectrum antiviral activity.

Deuterated analog also available.

Technical Data

M. Wt 255.74
Formula C10H21NO4.HCl
Storage Desiccate at -20°C
CAS Number 210110-90-0
PubChem ID 657399
InChI Key QPAFAUYWVZMWPR-ZSOUGHPYSA-N
Smiles CCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 19.18 75
DMSO 19.18 75

Preparing Stock Solutions

The following data is based on the product molecular weight 255.74. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.75 mM 5.21 mL 26.07 mL 52.14 mL
3.75 mM 1.04 mL 5.21 mL 10.43 mL
7.5 mM 0.52 mL 2.61 mL 5.21 mL
37.5 mM 0.1 mL 0.52 mL 1.04 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Platt et al (1994) N-Butyldeoxynojirimycin is a novel inhibitor of glycolipid biosynthesis. J.Biol.Chem. 269 8362 PMID: 8132559

Dwek et al (2002) Targeting glycosylation as a therapeutic approach. Nat.Rev.Drug Disc. 1 65

Noel et al (2008) Parallel improvements of sodium and chloride transport defects by migl. (n-butyldeoxynojyrimicin) in cystic fibrosis epithelial cells. J.Pharamcol.Exp.Ther. 325 1016


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Keywords: Miglustat hydrochloride, Miglustat hydrochloride supplier, α-glucosidase, alpha-glucosidase, I, II, inhibits, inhibitors, ceramide-specific, glycosyltransferases, Glycosylases, Carbohydrate, Metabolism, NBDNJ, N-Butyldeoxynojirimycin, hydrochloride, NB-DNJ, Other, Transferases, Antivirals, 3117, Tocris Bioscience

1 Citation for Miglustat hydrochloride

Citations are publications that use Tocris products. Selected citations for Miglustat hydrochloride include:

Huang et al (2011) Glucosylceramide synthase inhibitor PDMP sensitizes chronic myeloid leukemia T315I mutant to Bcr-Abl inhibitor and cooperatively induces glycogen synthase kinase-3-regulated apoptosis. FASEB J 25 3661 PMID: 21705667


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Literature in this Area

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