Miglustat hydrochloride

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Cat.No. 3117 - Miglustat hydrochloride | C10H21NO4.HCl | CAS No. 210110-90-0
Description: α-glucosidase I and II inhibitor. Also inhibits ceramide-specific glycosyltransferases
Alternative Names: N-Butyldeoxynojirimycin hydrochloride, NB-DNJ
Chemical Name: (2R,3R,4R,5S)-1-Butyl-2-(hydroxymethyl)-3,4,5-piperidinetriol hydrochloride
Datasheet
Citations (1)
Literature

Biological Activity

Orally active α-glucosidase I and II and ceramide-specific glycosyltransferase inhibitor. Rescues trafficking-deficient F508del-CFTR in human airway epithelial cells via inhibition of ER α-glucosidases I and II. Also has broad spectrum antiviral activity.

Technical Data

M. Wt 255.74
Formula C10H21NO4.HCl
Storage Desiccate at -20°C
CAS Number 210110-90-0
PubChem ID 657399
InChI Key QPAFAUYWVZMWPR-ZSOUGHPYSA-N
Smiles CCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 19.18 75
water 19.18 75

Preparing Stock Solutions

The following data is based on the product molecular weight 255.74. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.91 mL 19.55 mL 39.1 mL
5 mM 0.78 mL 3.91 mL 7.82 mL
10 mM 0.39 mL 1.96 mL 3.91 mL
50 mM 0.08 mL 0.39 mL 0.78 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Platt et al (1994) N-Butyldeoxynojirimycin is a novel inhibitor of glycolipid biosynthesis. J.Biol.Chem. 269 8362 PMID: 8132559

Dwek et al (2002) Targeting glycosylation as a therapeutic approach. Nat.Rev.Drug Disc. 1 65 PMID:

Noel et al (2008) Parallel improvements of sodium and chloride transport defects by miglustat (n-butyldeoxynojyrimicin) in cystic fibrosis epithelial cells. J.Pharamcol.Exp.Ther. 325 1016 PMID:


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Keywords: α-glucosidase alpha-glucosidase I II inhibits inhibitors ceramide-specific glycosyltransferases Glycosylases Carbohydrate Metabolism NBDNJ N-Butyldeoxynojirimycin hydrochloride NB-DNJ Glycosylases

1 Citation for Miglustat hydrochloride

Citations are publications that use Tocris products. Selected citations for Miglustat hydrochloride include:

Huang et al (2011) Glucosylceramide synthase inhibitor PDMP sensitizes chronic myeloid leukemia T315I mutant to Bcr-Abl inhibitor and cooperatively induces glycogen synthase kinase-3-regulated apoptosis. FASEB J 25 3661 PMID: 21705667


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New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

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Pathways for Miglustat hydrochloride

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