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Miglustat hydrochloride is an orally active α-glucosidase I and II and ceramide-specific glycosyltransferase inhibitor. Rescues trafficking-deficient F508del-CFTR in human airway epithelial cells via inhibition of ER α-glucosidases I and II. Also has broad spectrum antiviral activity.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 255.74. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.75 mM||5.21 mL||26.07 mL||52.14 mL|
|3.75 mM||1.04 mL||5.21 mL||10.43 mL|
|7.5 mM||0.52 mL||2.61 mL||5.21 mL|
|37.5 mM||0.1 mL||0.52 mL||1.04 mL|
References are publications that support the biological activity of the product.
Platt et al (1994) N-Butyldeoxynojirimycin is a novel inhibitor of glycolipid biosynthesis. J.Biol.Chem. 269 8362 PMID: 8132559
Dwek et al (2002) Targeting glycosylation as a therapeutic approach. Nat.Rev.Drug Disc. 1 65 PMID: 12119611
Noel et al (2008) Parallel improvements of sodium and chloride transport defects by migl. (n-butyldeoxynojyrimicin) in cystic fibrosis epithelial cells. J.Pharmacol.Exp.Ther. 325 1016 PMID: 18309088
If you know of a relevant reference for Miglustat hydrochloride, please let us know.
Keywords: Miglustat hydrochloride, Miglustat hydrochloride supplier, α-glucosidase, alpha-glucosidase, I, II, inhibits, inhibitors, ceramide-specific, glycosyltransferases, Glycosylases, Carbohydrate, Metabolism, NBDNJ, N-Butyldeoxynojirimycin, hydrochloride, NB-DNJ, Other, Transferases, Non-selective, Antivirals, 3117, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for Miglustat hydrochloride include:
Huang et al (2011) Glucosylceramide synthase inhibitor PDMP sensitizes chronic myeloid leukemia T315I mutant to Bcr-Abl inhibitor and cooperatively induces glycogen synthase kinase-3-regulated apoptosis. FASEB J 25 3661 PMID: 21705667
Do you know of a great paper that uses Miglustat hydrochloride from Tocris? Please let us know.
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