Orally active α-glucosidase I and II and ceramide-specific glycosyltransferase inhibitor. Rescues trafficking-deficient F508del-CFTR in human airway epithelial cells via inhibition of ER α-glucosidases I and II. Also has broad spectrum antiviral activity.
Deuterated analog also available.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 255.74. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.91 mL||19.55 mL||39.1 mL|
|5 mM||0.78 mL||3.91 mL||7.82 mL|
|10 mM||0.39 mL||1.96 mL||3.91 mL|
|50 mM||0.08 mL||0.39 mL||0.78 mL|
References are publications that support the products' biological activity.
Platt et al (1994) N-Butyldeoxynojirimycin is a novel inhibitor of glycolipid biosynthesis. J.Biol.Chem. 269 8362 PMID: 8132559
If you know of a relevant reference for Miglustat hydrochloride, please let us know.
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Keywords: Miglustat hydrochloride, supplier, α-glucosidase, alpha-glucosidase, I, II, inhibits, inhibitors, ceramide-specific, glycosyltransferases, Glycosylases, Carbohydrate, Metabolism, NBDNJ, N-Butyldeoxynojirimycin, hydrochloride, NB-DNJ, Other, Transferases, Glycosylases, Antivirals, Glycosylases, Tocris Bioscience
1 Citation for Miglustat hydrochloride
Citations are publications that use Tocris products. Selected citations for Miglustat hydrochloride include:
Huang et al (2011) Glucosylceramide synthase inhibitor PDMP sensitizes chronic myeloid leukemia T315I mutant to Bcr-Abl inhibitor and cooperatively induces glycogen synthase kinase-3-regulated apoptosis. FASEB J 25 3661 PMID: 21705667
Do you know of a great paper that uses Miglustat hydrochloride from Tocris? If so please let us know.
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New Product Guide (Spring/Summer 2017)
Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.
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