MG 624

Pricing Availability   Qty
Description: α7 neuronal nAChR antagonist
Chemical Name: N,N,N-Triethyl-2-[4-(2-phenylethenyl)phenoxy]ethanaminium iodide
Purity: ≥98% (HPLC)
Datasheet
Citations (3)
Reviews (1)
Literature (5)

Biological Activity for MG 624

MG 624 is a selective antagonist for neuronal α7 subunit- containing nAChR subtypes. Inhibits α-Bgtx binding to chick α7 and α4β2 subtypes with Ki values of 106 nM and 84 μM respectively.

Technical Data for MG 624

M. Wt 451.39
Formula C22H30NOI
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 77257-42-2
PubChem ID 6433339
InChI Key RDTKUZXIHMTSJO-UEIGIMKUSA-M
Smiles [I-].CC[N+](CC)(CC)CCOC1=CC=C(\C=C\C2=CC=CC=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for MG 624

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 9.03 20
ethanol 10

Preparing Stock Solutions for MG 624

The following data is based on the product molecular weight 451.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 11.08 mL 55.38 mL 110.77 mL
1 mM 2.22 mL 11.08 mL 22.15 mL
2 mM 1.11 mL 5.54 mL 11.08 mL
10 mM 0.22 mL 1.11 mL 2.22 mL

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Product Datasheets for MG 624

Certificate of Analysis / Product Datasheet
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References for MG 624

References are publications that support the biological activity of the product.

Gotti et al (1998) 4-Oxystilbene compounds are selective ligands for neuronal nicotinic abungarotoxin receptors. Br.J.Pharmacol. 124 1197 PMID: 9720791

Maggi et al (1999) Selective effects of a 4-oxystilbene derivative on wild and mutant neuronal chick α7 nicotinic receptor. Br.J.Pharmacol. 126 285 PMID: 10051147


If you know of a relevant reference for MG 624, please let us know.

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View all Nicotinic (α7) Receptor Antagonists

Keywords: MG 624, MG 624 supplier, α7, alpha7, neuronal, nicotinic, receptor, antagonist, a7, Receptors, Acetylcholine, nAChR, MG624, Nicotinic, (a7), 1356, Tocris Bioscience

3 Citations for MG 624

Citations are publications that use Tocris products. Selected citations for MG 624 include:

Chang et al (2015) Protection against β-amyloid-induced synaptic and memory impairments via altering β-amyloid assembly by bis(heptyl)-cognitin. Sci Rep 5 10256 PMID: 26194093

Cassilly et al (2016) SB-224289 Antagonizes the Antifungal Mechanism of the Marine Depsipeptide Papuamide A. Int J Clin Exp Pathol 11 e0154932 PMID: 27183222

Dolma et al (2016) Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells. Cancer Cell 29 859 PMID: 27300435


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Reviews for MG 624

Average Rating: 5 (Based on 1 Review.)

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The 5,760 bioactive compound library is a collated compound set of approved drugs and biologically active compound.
By Anonymous on 02/01/2020
Assay Type: In Vitro
Species: Other

Biologically active compounds that have been documented to interact with awide range of targets including SB-224289 (Cat. # 1221), MG-624 (Cat.# 1356), GVIA (Cat. No. 1085), DPAT hydrobromide (Cat. No. 1080) and valinomycin (VA; Cat. # 3373) were ordered from Tocris Bioscience

PMID: 27183222
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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