Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewMG 624
Description: α7 neuronal nAChR antagonist
Chemical Name: N,N,N-Triethyl-2-[4-(2-phenylethenyl)phenoxy]ethanaminium iodide
Purity: ≥98% (HPLC)
Biological Activity for MG 624
MG 624 is a selective antagonist for neuronal α7 subunit- containing nAChR subtypes. Inhibits α-Bgtx binding to chick α7 and α4β2 subtypes with Ki values of 106 nM and 84 μM respectively.
Technical Data for MG 624
| M. Wt | 451.39 |
| Formula | C22H30NOI |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 77257-42-2 |
| PubChem ID | 6433339 |
| InChI Key | RDTKUZXIHMTSJO-UEIGIMKUSA-M |
| Smiles | [I-].CC[N+](CC)(CC)CCOC1=CC=C(\C=C\C2=CC=CC=C2)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for MG 624
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 9.03 | 20 | |
| ethanol | 10 |
Preparing Stock Solutions for MG 624
The following data is based on the product molecular weight 451.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 11.08 mL | 55.38 mL | 110.77 mL |
| 1 mM | 2.22 mL | 11.08 mL | 22.15 mL |
| 2 mM | 1.11 mL | 5.54 mL | 11.08 mL |
| 10 mM | 0.22 mL | 1.11 mL | 2.22 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for MG 624
References for MG 624
References are publications that support the biological activity of the product.
Gotti et al (1998) 4-Oxystilbene compounds are selective ligands for neuronal nicotinic abungarotoxin receptors. Br.J.Pharmacol. 124 1197 PMID: 9720791
Maggi et al (1999) Selective effects of a 4-oxystilbene derivative on wild and mutant neuronal chick α7 nicotinic receptor. Br.J.Pharmacol. 126 285 PMID: 10051147
If you know of a relevant reference for MG 624, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: MG 624, MG 624 supplier, α7, alpha7, neuronal, nicotinic, receptor, antagonist, a7, Receptors, Acetylcholine, nAChR, MG624, Nicotinic, (a7), 1356, Tocris Bioscience
3 Citations for MG 624
Citations are publications that use Tocris products. Selected citations for MG 624 include:
Chang et al (2015) Protection against β-amyloid-induced synaptic and memory impairments via altering β-amyloid assembly by bis(heptyl)-cognitin. Sci Rep 5 10256 PMID: 26194093
Cassilly et al (2016) SB-224289 Antagonizes the Antifungal Mechanism of the Marine Depsipeptide Papuamide A. Int J Clin Exp Pathol 11 e0154932 PMID: 27183222
Dolma et al (2016) Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells. Cancer Cell 29 859 PMID: 27300435
Do you know of a great paper that uses MG 624 from Tocris? Please let us know.
Reviews for MG 624
Average Rating: 5 (Based on 1 Review.)
Have you used MG 624?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Filter by:
The 5,760 bioactive compound library is a collated compound set of approved drugs and biologically active compound.
By
Anonymous on 02/01/2020
Assay Type: In Vitro
Species: Other
Biologically active compounds that have been documented to interact with awide range of targets including SB-224289 (Cat. # 1221), MG-624 (Cat.# 1356), GVIA (Cat. No. 1085), DPAT hydrobromide (Cat. No. 1080) and valinomycin (VA; Cat. # 3373) were ordered from Tocris Bioscience
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Pain Research Product Guide
A collection of over 280 products for pain research, the guide includes research tools for the study of:
- Nociception
- Ion Channels
- G-Protein-Coupled Receptors
- Intracellular Signaling
Nicotinic ACh Receptors Scientific Review
Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.
Alzheimer's Poster
Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.
Learning & Memory Poster
Recognition memory enables us to make judgements about whether or not we have encountered a particular stimulus before. This poster outlines the cellular mechanisms underlying recognition memory and its links to long-term depression, as well as the use of pharmacological intervention to assess the role of neurotransmitters in recognition memory.
Pain Poster
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.