MG 624

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Cat.No. 1356 - MG 624 | C22H30NOI | CAS No. 77257-42-2
Description: α7 neuronal nicotinic receptor antagonist
Chemical Name: N,N,N-Triethyl-2-[4-(2-phenylethenyl)phenoxy]ethanaminium iodide
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

A selective antagonist for neuronal α7 subunit- containing nAChR subtypes. Inhibits α-Bgtx binding to chick α7 and α4β2 subtypes with Ki values of 106 nM and 84 μM respectively.

Compound Libraries

MG 624 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 451.39
Formula C22H30NOI
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 77257-42-2
PubChem ID 6433339
InChI Key RDTKUZXIHMTSJO-UEIGIMKUSA-M
Smiles [I-].CC[N+](CC)(CC)CCOC1=CC=C(\C=C\C2=CC=CC=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 9.03 20
ethanol 10

Preparing Stock Solutions

The following data is based on the product molecular weight 451.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.22 mL 11.08 mL 22.15 mL
5 mM 0.44 mL 2.22 mL 4.43 mL
10 mM 0.22 mL 1.11 mL 2.22 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Gotti et al (1998) 4-Oxystilbene compounds are selective ligands for neuronal nicotinic abungarotoxin receptors. Br.J.Pharmacol. 124 1197 PMID: 9720791

Maggi et al (1999) Selective effects of a 4-oxystilbene derivative on wild and mutant neuronal chick α7 nicotinic receptor. Br.J.Pharmacol. 126 285 PMID: 10051147


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View Related Products by Product Action

View all Nicotinic (α7) Receptor Antagonists

Keywords: MG 624, supplier, α7, alpha7, neuronal, nicotinic, receptor, antagonist, a7, Receptors, Acetylcholine, nAChR, MG624, Nicotinic, (a7), Receptors, Nicotinic, (a7), Receptors, Tocris Bioscience

1 Citation for MG 624

Citations are publications that use Tocris products. Selected citations for MG 624 include:

Cassilly et al (2016) SB-224289 Antagonizes the Antifungal Mechanism of the Marine Depsipeptide Papuamide A. Int J Clin Exp Pathol 11 e0154932 PMID: 27183222


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