Methylergometrine maleate

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Description: Active metabolite of methysergide (Cat. No. 1064)
Alternative Names: Methylergonovine maleate
Chemical Name: [8β(S)]-9,10-Didehydro-N-[1-(hydroxymethyl)propyl]-6-methylergoline-8-carboxamide maleate
Purity: ≥98% (HPLC)
Citations (2)
Literature (2)

Biological Activity for Methylergometrine maleate

Methylergometrine maleate is an active metabolite of methysergide (Cat. No. 1064); uterotonic agent and oxytocic.

Technical Data for Methylergometrine maleate

M. Wt 455.51
Formula C20H25N3O2.C4H4O4
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 57432-61-8
PubChem ID 5281072
Smiles OC(=O)\C=C/C(O)=O.[H][C@](CC)(CO)NC(=O)[C@@]1([H])CN(C)[C@]2([H])CC3=CNC4=C3C(=CC=C4)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Methylergometrine maleate

Solvent Max Conc. mg/mL Max Conc. mM
water 25

Preparing Stock Solutions for Methylergometrine maleate

The following data is based on the product molecular weight 455.51. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 8.78 mL 43.91 mL 87.81 mL
1.25 mM 1.76 mL 8.78 mL 17.56 mL
2.5 mM 0.88 mL 4.39 mL 8.78 mL
12.5 mM 0.18 mL 0.88 mL 1.76 mL

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Product Datasheets for Methylergometrine maleate

References for Methylergometrine maleate

References are publications that support the biological activity of the product.

MacLennan and Martin (1990) Actions of non-peptide ergot alkaloids at 5-HT1-like and 5-HT2 receptors mediating vascular smooth muscle contraction. Naunyn Schmiedebergs Arch.Pharmacol. 342 120 PMID: 2234096

Muller-Schweinitzer and Tapparelli (1986) Methylergometrine, an active metabolite of methysergide. Cephalalgia 6 35 PMID: 3698092

Pertz (1993) 5-Hydroxytryptamine (5-HT) contracts the guinea-pig isolated iliac artery via 5-HT1-like and 5-HT2 receptors. Naunyn Schmiedebergs Arch.Pharmacol. 348 558 PMID: 8133899

Merck Index 12 6147

If you know of a relevant reference for Methylergometrine maleate, please let us know.

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Keywords: Methylergometrine maleate, Methylergometrine maleate supplier, Active, metabolite, methysergide, Serotonin, 5-HT-, 5-Hydroxytryptamine, Receptors, 5-HT, 5-HT1, 5-HT2, antagonists, Methylergonovine, maleate, Non-selective, 0549, Tocris Bioscience

2 Citations for Methylergometrine maleate

Citations are publications that use Tocris products. Selected citations for Methylergometrine maleate include:

Murray et al (2011) Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors. J Neurophysiol 106 925 PMID: 21653728

Chan et al (2015) Ergot Alkaloids (Re)generate New Leads as Antiparasitics. Cell Signal 9 e0004063 PMID: 26367744

Do you know of a great paper that uses Methylergometrine maleate from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

5-HT Receptors Scientific Review

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.