Methylergometrine maleate

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Cat.No. 0549 - Methylergometrine maleate | C20H25N3O2.C4H4O4 | CAS No. 57432-61-8
Description: Active metabolite of methysergide (Cat. No. 1064)
Alternative Names: Methylergonovine maleate
Chemical Name: [8β(S)]-9,10-Didehydro-N-[1-(hydroxymethyl)propyl]-6-methylergoline-8-carboxamide maleate
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews
Literature

Biological Activity

Active metabolite of methysergide (Cat. No. 1064); uterotonic agent and oxytocic.

Technical Data

M. Wt 455.51
Formula C20H25N3O2.C4H4O4
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 57432-61-8
PubChem ID 5281072
InChI Key NOFOWWRHEPHDCY-DAUURJMHSA-N
Smiles OC(=O)\C=C/C(O)=O.[H][C@](CC)(CO)NC(=O)[C@@]1([H])CN(C)[C@]2([H])CC3=CNC4=C3C(=CC=C4)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 25 mM in water

References

References are publications that support the biological activity of the product.

MacLennan and Martin (1990) Actions of non-peptide ergot alkaloids at 5-HT1-like and 5-HT2 receptors mediating vascular smooth muscle contraction. Naunyn Schmiedebergs Arch.Pharmacol. 342 120 PMID: 2234096

Muller-Schweinitzer and Tapparelli (1986) Methylergometrine, an active metabolite of methysergide. Cephalalgia 6 35 PMID: 3698092

Pertz (1993) 5-Hydroxytryptamine (5-HT) contracts the guinea-pig isolated iliac artery via 5-HT1-like and 5-HT2 receptors. Naunyn Schmiedebergs Arch.Pharmacol. 348 558 PMID: 8133899

Merck Index 12 6147


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2 Citations for Methylergometrine maleate

Citations are publications that use Tocris products. Selected citations for Methylergometrine maleate include:

Chan et al (2015) Ergot Alkaloids (Re)generate New Leads as Antiparasitics. Cell Signal 9 e0004063 PMID: 26367744

Murray et al (2011) Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors. J Neurophysiol 106 925 PMID: 21653728


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