Active metabolite of methysergide (Cat. No. 1064); uterotonic agent and oxytocic.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 25 mM in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 455.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.2 mL||10.98 mL||21.95 mL|
|5 mM||0.44 mL||2.2 mL||4.39 mL|
|10 mM||0.22 mL||1.1 mL||2.2 mL|
|50 mM||0.04 mL||0.22 mL||0.44 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
MacLennan and Martin (1990) Actions of non-peptide ergot alkaloids at 5-HT1-like and 5-HT2 receptors mediating vascular smooth muscle contraction. Naunyn Schmiedebergs Arch.Pharmacol. 342 120 PMID: 2234096
Muller-Schweinitzer and Tapparelli (1986) Methylergometrine, an active metabolite of methysergide. Cephalalgia 6 35 PMID: 3698092
Pertz (1993) 5-Hydroxytryptamine (5-HT) contracts the guinea-pig isolated iliac artery via 5-HT1-like and 5-HT2 receptors. Naunyn Schmiedebergs Arch.Pharmacol. 348 558 PMID: 8133899
If you know of a relevant reference for Methylergometrine maleate, please let us know.
Keywords: Active metabolite methysergide Serotonin 5-HT- 5-Hydroxytryptamine Receptors 5-HT 5-HT1 5-HT2 antagonists Methylergonovine maleate Non-selective 5-HT
1 Citation for Methylergometrine maleate
Citations are publications that use Tocris products. Selected citations for Methylergometrine maleate include:
Chan et al (2015) Ergot Alkaloids (Re)generate New Leads as Antiparasitics. Cell Signal 9 e0004063 PMID: 26367744
Do you know of a great paper that uses Methylergometrine maleate from Tocris? If so please let us know.
Literature in this Area
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.