Methysergide maleate

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Cat.No. 1064 - Methysergide maleate | C21H27N3O2.C4H4O4 | CAS No. 129-49-7
Description: 5-HT1/5-HT2 antagonist
Chemical Name: [8β(S)]-9,10-Didehydro-N-[1-(hydroxymethyl)propyl]-1,6-dimethylergoline-8-carboxamide maleate
Purity: ≥99% (HPLC)
Datasheet
Citations (7)
Reviews
Literature (3)

Biological Activity

Mixed 5-HT1/5-HT2 receptor antagonist.

Technical Data

M. Wt 469.54
Formula C21H27N3O2.C4H4O4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 129-49-7
PubChem ID 5281073
InChI Key LWYXFDXUMVEZKS-ZVFOLQIPSA-N
Smiles OC(=O)\C=C/C(O)=O.[H][C@@]12CC3=CN(C)C4=CC=CC(=C34)C1=C[C@H](CN2C)C(=O)N[C@@H](CC)CO

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 4.7 10 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 469.54. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.3 mL 106.49 mL 212.97 mL
0.5 mM 4.26 mL 21.3 mL 42.59 mL
1 mM 2.13 mL 10.65 mL 21.3 mL
5 mM 0.43 mL 2.13 mL 4.26 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Hoyer et al (1994) VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol.Rev. 46 157 PMID: 7938165

Merck Index 12 6217


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Keywords: Methysergide maleate, Methysergide maleate supplier, 5-HT1, 5-HT2, antagonists, Non-Selective, 5-Hydroxytryptamine, Receptors, Serotonin, Non-selective, 5-HT, 1064, Tocris Bioscience

7 Citations for Methysergide maleate

Citations are publications that use Tocris products. Selected citations for Methysergide maleate include:

Williams et al (2012) Reduced levels of serotonin 2A receptors underlie resistance of Egr3-deficient mice to locomotor suppression by cloz. Neuropsychopharmacology 37 2285 PMID: 22692564

Murray et al (2010) Recovery of motoneuron and locomotor function after spinal cord injury depends on constitutive activity in 5-HT2C receptors. Nat Med 16 694 PMID: 20512126

Murray et al (2011) Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors. J Neurophysiol 106 925 PMID: 21653728

Dacks et al (2009) Serotonin modulates olfactory processing in the antennal lobe of Drosophila. J Neurosci 23 366 PMID: 19863268

Huang et al (2009) Autocrine and paracrine roles for ATP and serotonin in mouse taste buds. Neuron 29 13909 PMID: 19890001

González-Maeso et al (2007) Hallucinogens recruit specific cortical 5-HT(2A) receptor-mediated signaling pathways to affect behavior. J Neurosci 53 439 PMID: 17270739

Moreno et al (2011) Maternal influenza viral infection causes schizophrenia-like alterations of 5-HT2A and mGlu2 receptors in the adult offspring. Hypertension 31 1863 PMID: 21289196


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Literature in this Area

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Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

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