Methysergide maleate

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Cat.No. 1064 - Methysergide maleate | C21H27N3O2.C4H4O4 | CAS No. 129-49-7
Description: 5-HT1/5-HT2 antagonist
Chemical Name: [8β(S)]-9,10-Didehydro-N-[1-(hydroxymethyl)propyl]-1,6-dimethylergoline-8-carboxamide maleate
Purity: ≥99% (HPLC)
Datasheet
Citations (6)
Literature

Biological Activity

Mixed 5-HT1/5-HT2 receptor antagonist.

Technical Data

M. Wt 469.54
Formula C21H27N3O2.C4H4O4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 129-49-7
PubChem ID 5281073
InChI Key LWYXFDXUMVEZKS-ZVFOLQIPSA-N
Smiles OC(=O)\C=C/C(O)=O.[H][C@@]12CC3=CN(C)C4=CC=CC(=C34)C1=C[C@H](CN2C)C(=O)N[C@@H](CC)CO

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 4.7 10mM with gentle warming
phosphate buffered saline 4.7 10mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 469.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.13 mL 10.65 mL 21.3 mL
5 mM 0.43 mL 2.13 mL 4.26 mL
10 mM 0.21 mL 1.06 mL 2.13 mL
50 mM 0.04 mL 0.21 mL 0.43 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Hoyer et al (1994) VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol.Rev. 46 157 PMID: 7938165

Merck Index 12 6217 PMID:


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Keywords: 5-HT1 5-HT2 antagonists Non-Selective 5-Hydroxytryptamine Receptors Serotonin Non-selective 5-HT

6 Citations for Methysergide maleate

Citations are publications that use Tocris products. Selected citations for Methysergide maleate include:

Williams et al (2012) Reduced levels of serotonin 2A receptors underlie resistance of Egr3-deficient mice to locomotor suppression by clozapine. Neuropsychopharmacology 37 2285 PMID: 22692564

Moreno et al (2011) Maternal influenza viral infection causes schizophrenia-like alterations of 5-HT2A and mGlu2 receptors in the adult offspring. Hypertension 31 1863 PMID: 21289196

Murray et al (2010) Recovery of motoneuron and locomotor function after spinal cord injury depends on constitutive activity in 5-HT2C receptors. Nat Med 16 694 PMID: 20512126

Dacks et al (2009) Serotonin modulates olfactory processing in the antennal lobe of Drosophila. J Neurosci 23 366 PMID: 19863268

Huang et al (2009) Autocrine and paracrine roles for ATP and serotonin in mouse taste buds. Neuron 29 13909 PMID: 19890001

González-Maeso et al (2007) Hallucinogens recruit specific cortical 5-HT(2A) receptor-mediated signaling pathways to affect behavior. J Neurosci 53 439 PMID: 17270739


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5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

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Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

Pathways for Methysergide maleate

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