Methysergide maleate

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Cat.No. 1064 - Methysergide maleate | C21H27N3O2.C4H4O4 | CAS No. 129-49-7
Description: 5-HT1/5-HT2 antagonist
Chemical Name: [8β(S)]-9,10-Didehydro-N-[1-(hydroxymethyl)propyl]-1,6-dimethylergoline-8-carboxamide maleate
Purity: ≥99% (HPLC)
Datasheet
Citations (7)
Reviews
Literature (3)

Biological Activity for Methysergide maleate

Methysergide maleate is a mixed 5-HT1/5-HT2 receptor antagonist.

Technical Data for Methysergide maleate

M. Wt 469.54
Formula C21H27N3O2.C4H4O4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 129-49-7
PubChem ID 5281073
InChI Key LWYXFDXUMVEZKS-ZVFOLQIPSA-N
Smiles OC(=O)\C=C/C(O)=O.[H][C@@]12CC3=CN(C)C4=CC=CC(=C34)C1=C[C@H](CN2C)C(=O)N[C@@H](CC)CO

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Methysergide maleate

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 4.7 10 with gentle warming

Preparing Stock Solutions for Methysergide maleate

The following data is based on the product molecular weight 469.54. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.3 mL 106.49 mL 212.97 mL
0.5 mM 4.26 mL 21.3 mL 42.59 mL
1 mM 2.13 mL 10.65 mL 21.3 mL
5 mM 0.43 mL 2.13 mL 4.26 mL

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Product Datasheets for Methysergide maleate

Certificate of Analysis / Product Datasheet
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References for Methysergide maleate

References are publications that support the biological activity of the product.

Hoyer et al (1994) VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol.Rev. 46 157 PMID: 7938165

Merck Index 12 6217


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Keywords: Methysergide maleate, Methysergide maleate supplier, 5-HT1, 5-HT2, antagonists, Non-Selective, 5-Hydroxytryptamine, Receptors, Serotonin, Non-selective, 5-HT, 1064, Tocris Bioscience

7 Citations for Methysergide maleate

Citations are publications that use Tocris products. Selected citations for Methysergide maleate include:

Murray et al (2011) Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors. J Neurophysiol 106 925 PMID: 21653728

Dacks et al (2009) Serotonin modulates olfactory processing in the antennal lobe of Drosophila. J Neurosci 23 366 PMID: 19863268

Huang et al (2009) Autocrine and paracrine roles for ATP and serotonin in mouse taste buds. Neuron 29 13909 PMID: 19890001

Moreno et al (2011) Maternal influenza viral infection causes schizophrenia-like alterations of 5-HT2A and mGlu2 receptors in the adult offspring. Hypertension 31 1863 PMID: 21289196


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


GPCR Product Listing

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
5-HT Receptors Scientific Review

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.