Methyl 2,5-dihydroxycinnamate

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Cat.No. 0577 - Methyl 2,5-dihydroxycinnamate | C10H10O4 | CAS No. 63177-57-1
Description: EGFR-kinase inhibitor
Alternative Names: Erbstatin analog
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Erbstatin analog. Inhibitor of EGF receptor-associated tyrosine kinases.

Technical Data

M. Wt 194.19
Formula C10H10O4
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 63177-57-1
PubChem ID 5353609
InChI Key BQCNSTFWSKOWMA-GORDUTHDSA-N
Smiles COC(=O)\C=C\C1=C(O)C=CC(O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in ethanol

Preparing Stock Solutions

The following data is based on the product molecular weight 194.19. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.15 mL 25.75 mL 51.5 mL
5 mM 1.03 mL 5.15 mL 10.3 mL
10 mM 0.51 mL 2.57 mL 5.15 mL
50 mM 0.1 mL 0.51 mL 1.03 mL

Molarity Calculator

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Reconstitution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Isshiki et al (1990) Inhibition of epidermal growth factor-induced DNA synthesis by tyrosine kinase inhibitors. FEBS Lett. 260 198 PMID: 2298299


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View Related Products by Product Action

View all EGFR Inhibitors

Keywords: EGFR kinase inhibitors inhibits Epidermal Growth Factors Receptors ErbB Her RTK Receptor Tyrosine Kinases RTKs Methyl-25-dihydroxycinnamate Erbstatin analog EGFR

Citations for Methyl 2,5-dihydroxycinnamate

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases
Angiogenesis in Cancer

Angiogenesis in Cancer Poster

Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

Schizophrenia

Schizophrenia Poster

Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster highlights the targets and pathways representing the most promising strategies to pursue for novel drug development.

Pathways for Methyl 2,5-dihydroxycinnamate

Protocols

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