Methiothepin maleate

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Cat.No. 0582 - Methiothepin maleate | C20H24N2S2.C4H4O4 | CAS No. 19728-88-2
Description: Has moderate affinity for 5-ht5 and high affinity for 5-ht6 and 5-HT7. Also antagonist at 5-HT1 and 5-HT2
Alternative Names: Metitepine
Chemical Name: 1-[10,11-Dihydro-8-(methylthio)dibenzo(Z)[b,f]thiepin-10-yl]-4-methylpiperazine maleate
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Potent 5-HT2 antagonist, also active as 5-HT1 antagonist. Differentiates 5-HT1D sub-types. Also displays affinity for rodent 5-HT5B, 5-HT5A, 5-HT7 and 5-HT6 receptors (pK1 values are 6.6, 7.0, 8.4 and 8.7 respectively).

Compound Libraries

Methiothepin maleate is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 472.62
Formula C20H24N2S2.C4H4O4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 19728-88-2
PubChem ID 5358812
InChI Key IWDBEHWZGDSFHR-BTJKTKAUSA-N
Smiles [H]OC(=O)\C=C/C(=O)O[H].CSC1=CC2=C(SC3=C(CC2N2CCN(C)CC2)C=CC=C3)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 47.26 100

Preparing Stock Solutions

The following data is based on the product molecular weight 472.62. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.12 mL 10.58 mL 21.16 mL
5 mM 0.42 mL 2.12 mL 4.23 mL
10 mM 0.21 mL 1.06 mL 2.12 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Wilkinson and Middlemiss (1992) Metitepine distinguishes two receptors mediating inhibition of [3H]-5-hydroxytryptamine release in guinea pig hippocampus. Naunyn Schmiedebergs Arch.Pharmacol. 345 696 PMID: 1321958

Hoyer (1989) The peripheral actions of 5-HT. Ed. Fozard. Oxford. PMID:


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Keywords: Methiothepin maleate, supplier, moderate, affinity, 5-ht5, high, 5-ht6, 5-HT7, antagonists, 5-HT1, 5-HT2, Serotonin, 5-HT-, 5-Hydroxytryptamine, Receptors, 5-HT, Metitepine, Non-selective, 5-HT, Non-selective, 5-HT, Tocris Bioscience

1 Citation for Methiothepin maleate

Citations are publications that use Tocris products. Selected citations for Methiothepin maleate include:

Conley et al (2015) Evaluation of AaDOP2 receptor antagonists reveals antidepressants and antipsychotics as novel lead molecules for control of the yellow fever mosquito, Aedes aegypti. Oncotarget 352 53 PMID: 25332454


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