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Potent and selective competitive tachykinin NK2 receptor antagonist (pKB = 8.1 - 10.1). Displays 100- and > 1200-fold selectivity over NK1 and NK3 receptors respectively. Active in vivo.
(Modifications: X = Dpr, Cyclized, 4-β-1-β-lactam)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Lecci et al (1998) The role of tachykinin NK1 and NK2 receptors in atropine-resistant colonic propulsion in anaesthetized guinea-pigs. Br.J.Pharmacol. 124 27 PMID: 9630339
Maggi et al (1994) MEN 10,627, a novel polycyclic peptide antagonist of tachykinin NK2 receptors. J.Pharmacol.Exp.Ther. 271 1489 PMID: 7996462
Quartara et al (1996) A review of the design, synthesis and biological activity of the bicyclic hexapeptide tachykinin NK2 antagonist MEN 10627. Regul.Pept. 65 55 PMID: 8876036
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Keywords: MEN 10627, MEN 10627 supplier, Potent, selective, NK2, antagonists, Tachykinin, Receptors, Neurokinin, MEN10627, Receptor, 1633, Tocris Bioscience
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Literature in this Area
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.