MEN 10627

Discontinued Product

MEN 10627 (Cat. No. 1633) has been withdrawn from sale for commercial reasons.
Cat.No. 1633 - MEN 10627 | cyclo(Dpr-Leu-Met-Asp-Trp-Phe) (4-β-1-β-lactam) | CAS No. 157351-81-0
Description: Potent, selective NK2 antagonist
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent and selective competitive tachykinin NK2 receptor antagonist (pKB = 8.1 - 10.1). Displays 100- and > 1200-fold selectivity over NK1 and NK3 receptors respectively. Active in vivo.

Technical Data

M. Wt 760.9
Formula C38H48N8O7S
Sequence XLMDWF

(Modifications: X = Dpr, Cyclized, 4-β-1-β-lactam)

Storage Desiccate at -20°C
CAS Number 157351-81-0
Smiles CSCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)C2CNC(=O)C[C@H](NC1=O)C(=O)N[C@@H](CC1=CNC3=C1C=CC=C3)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

References

References are publications that support the biological activity of the product.

Lecci et al (1998) The role of tachykinin NK1 and NK2 receptors in atropine-resistant colonic propulsion in anaesthetized guinea-pigs. Br.J.Pharmacol. 124 27 PMID: 9630339

Maggi et al (1994) MEN 10,627, a novel polycyclic peptide antagonist of tachykinin NK2 receptors. J.Pharmacol.Exp.Ther. 271 1489 PMID: 7996462

Quartara et al (1996) A review of the design, synthesis and biological activity of the bicyclic hexapeptide tachykinin NK2 antagonist MEN 10627. Regul.Pept. 65 55 PMID: 8876036

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Keywords: MEN 10627, MEN 10627 supplier, Potent, selective, NK2, antagonists, Tachykinin, Receptors, Neurokinin, MEN10627, Receptor, 1633, Tocris Bioscience

Citations for MEN 10627

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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Peptides Involved in Appetite Modulation

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

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Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.

Depression

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.