Melanocyte-stimulating hormone release inhibiting factor

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Cat.No. 1929 - Melanocyte-stimulating hormone release inhibiting factor | Pro-Leu-Gly-NH2 | CAS No. 2002-44-0
Description: Inhibitor of α-MSH release; inhibits opioid effects in vivo
Alternative Names: Pro-Leu-Gly amide, MIF-I, PLG

Biological Activity

Inhibitor of melanocyte-stimulating hormone (MSH) release. Blocks the release of α-MSH, increases brain dopamine levels and antagonizes physiological and behavioral opioid effects in vivo.

Technical Data

M. Wt 284.36
Formula C13H24N4O3
Sequence PLG

(Modifications: Gly-3 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 2002-44-0
PubChem ID 92910
Smiles [H]N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 284.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.52 mL 17.58 mL 35.17 mL
5 mM 0.7 mL 3.52 mL 7.03 mL
10 mM 0.35 mL 1.76 mL 3.52 mL
50 mM 0.07 mL 0.35 mL 0.7 mL

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References are publications that support the products' biological activity.

Kavaliers and Hirst (1986) Inhibitory influences of FMRFamide and PLG on stress-induced opioid analgesia and activity. Brain Res. 372 370 PMID: 2871903

Mishra et al (1983) Pharmacology of L-Prolyl-L-Leucyl-Glycinamide (PLG): a review. Methods Find.Exp.Clin.Pharmacol. 5 203 PMID: 6136640

Plotnikoff and Kastin (1974) Pharmacological studies with a tripeptide, Prolyl-Leucyl Glycine amide. Arch.Int.Pharmacodyn.Ther. 211 211 PMID: 4156639

Pugsley and Lippmann (1977) Synthetic melanocyte stimulating hormone release inhibiting factor (MIF). Part III: effect of L-prolyl-N-methyl-D-leucyl-glycinamide and MIF on biogenic amine turnover. Arzneimittelforschung 27 2293 PMID: 23796

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Keywords: α-MSH alpha-MSH a-MSH release inhibits inhibitors melanocortin receptors Pro-Leu-Gly amide MIF-I PLG Melanocortin (MC) Receptor Peptide

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