Melanocyte-stimulating hormone release inhibiting factor
Inhibitor of melanocyte-stimulating hormone (MSH) release. Blocks the release of α-MSH, increases brain dopamine levels and antagonizes physiological and behavioral opioid effects in vivo.
(Modifications: Gly-3 = C-terminal amide)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Preparing Stock Solutions
The following data is based on the product molecular weight 284.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.52 mL||17.58 mL||35.17 mL|
|5 mM||0.7 mL||3.52 mL||7.03 mL|
|10 mM||0.35 mL||1.76 mL||3.52 mL|
|50 mM||0.07 mL||0.35 mL||0.7 mL|
References are publications that support the products' biological activity.
Kavaliers and Hirst (1986) Inhibitory influences of FMRFamide and PLG on stress-induced opioid analgesia and activity. Brain Res. 372 370 PMID: 2871903
Mishra et al (1983) Pharmacology of L-Prolyl-L-Leucyl-Glycinamide (PLG): a review. Methods Find.Exp.Clin.Pharmacol. 5 203 PMID: 6136640
Plotnikoff and Kastin (1974) Pharmacological studies with a tripeptide, Prolyl-Leucyl Glycine amide. Arch.Int.Pharmacodyn.Ther. 211 211 PMID: 4156639
Pugsley and Lippmann (1977) Synthetic melanocyte stimulating hormone release inhibiting factor (MIF). Part III: effect of L-prolyl-N-methyl-D-leucyl-glycinamide and MIF on biogenic amine turnover. Arzneimittelforschung 27 2293 PMID: 23796
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Keywords: Melanocyte-stimulating hormone release inhibiting factor, supplier, α-MSH, alpha-MSH, a-MSH, release, inhibits, inhibitors, melanocortin, receptors, Pro-Leu-Gly, amide, MIF-I, PLG, Miscellaneous/Non-selective, Opioids, Dopaminergic-Related, Melanocortin, Receptors, Melanocortin, Receptors, Tocris Bioscience
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.