Melanocyte-stimulating hormone release inhibiting factor

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Cat.No. 1929 - Melanocyte-stimulating hormone release inhibiting factor | Pro-Leu-Gly-NH2 | CAS No. 2002-44-0
Description: Inhibitor of α-MSH release; inhibits opioid effects in vivo
Alternative Names: Pro-Leu-Gly amide, MIF-I, PLG
Datasheet
Citations
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Biological Activity

Inhibitor of melanocyte-stimulating hormone (MSH) release. Blocks the release of α-MSH, increases brain dopamine levels and antagonizes physiological and behavioral opioid effects in vivo.

Technical Data

M. Wt 284.36
Formula C13H24N4O3
Sequence PLG

(Modifications: Gly-3 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 2002-44-0
PubChem ID 92910
InChI Key NOOJLZTTWSNHOX-UWVGGRQHSA-N
Smiles [H]N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

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References

References are publications that support the biological activity of the product.

Kavaliers and Hirst (1986) Inhibitory influences of FMRFamide and PLG on stress-induced opioid analgesia and activity. Brain Res. 372 370 PMID: 2871903

Mishra et al (1983) Pharmacology of L-Prolyl-L-Leucyl-Glycinamide (PLG): a review. Methods Find.Exp.Clin.Pharmacol. 5 203 PMID: 6136640

Plotnikoff and Kastin (1974) Pharmacological studies with a tripeptide, Prolyl-Leucyl Glycine amide. Arch.Int.Pharmacodyn.Ther. 211 211 PMID: 4156639

Pugsley and Lippmann (1977) Synthetic melanocyte stimulating hormone release inhibiting factor (MIF). Part III: effect of L-prolyl-N-methyl-D-leucyl-glycinamide and MIF on biogenic amine turnover. Arzneimittelforschung 27 2293 PMID: 23796


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