Non-competitive nicotinic acetylcholine receptor antagonist. Displays antidepressant-like effects in mice.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 203.75. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.91 mL||24.54 mL||49.08 mL|
|5 mM||0.98 mL||4.91 mL||9.82 mL|
|10 mM||0.49 mL||2.45 mL||4.91 mL|
|50 mM||0.1 mL||0.49 mL||0.98 mL|
References are publications that support the biological activity of the product.
Ostroumov et al (2007) Modeling study of mecamylamine block of muscle type acetylcholine receptors. Eur.Biophys.J. 37 393 PMID: 17938901
Rabenstein et al (2006) The nicotinic antagonist mecamylamine has antidepressant-like effects in wild-type but not β2- or α7-nicotinic acetylcholine receptor subunit knockout mice. Psychopharmacol. 189 395
If you know of a relevant reference for Mecamylamine hydrochloride, please let us know.
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Keywords: Mecamylamine hydrochloride, Mecamylamine hydrochloride supplier, Non-competitive, nicotinic, receptors, antagonists, Acetylcholine, Non-Selective, Subtypes, nAChR, Nicotinic, Receptors, (Non-selective), 2843, Tocris Bioscience
17 Citations for Mecamylamine hydrochloride
Citations are publications that use Tocris products. Selected citations for Mecamylamine hydrochloride include:
Shin et al (2015) Muscarinic regulation of dopamine and glutamate transmission in the nucleus accumbens. J Neurophysiol 112 8124 PMID: 26080439
Leão et al (2015) Interconnection and synchronization of neuronal populations in the mouse medial septum/diagonal band of Broca. J Neurosci 113 971 PMID: 25392162
Liu et al (2015) Muscarinic receptors modulate dendrodendritic inhibitory synapses to sculpt glomerular output. Front Cell Neurosci 35 5680 PMID: 25855181
Elgueta et al (2015) Acetylcholine induces GABA release onto rod bipolar cells through heteromeric nicotinic receptors expressed in A17 amacrine cells. PLoS One 9 6 PMID: 25709566
Bryant et al (2015) Cholinergic control of γ power in the midbrain spatial attention network. Elife 35 761 PMID: 25589769
Saunders et al (2015) Corelease of acetylcholine and GABA from cholinergic forebrain neurons. Sci Rep 4 PMID: 25723967
Costello et al (2014) Comparison of the reinforcing properties of nicotine and cigarette smoke extract in rats. Neuropsychopharmacology 39 1843 PMID: 24513971
Kam et al (2016) Interictal spikes during sleep are an early defect in the Tg2576 mouse model of β-amyloid neuropathology. Proc Natl Acad Sci U S A 6 20119 PMID: 26818394
Herman et al (2016) A cholinergic basal forebrain feeding circuit modulates appetite suppression Nature 538 253 PMID: 27698417
Mamaligas et al (2016) Nicotinic and opioid receptor regulation of striatal dopamine D2-receptor mediated transmission Scientific Reports 6 37834 PMID: 27886263
Dannenberg et al (2015) Synergy of direct and indirect cholinergic septo-hippocampal pathways coordinates firing in hippocampal networks. J Neurosci 35 8394 PMID: 26041909
Falgairolle and O'Donovan (2015) Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons. Eur J Neurosci 10 e0131430 PMID: 26102354
Higley et al (2011) Cholinergic interneurons mediate fast VGluT3-dependent glutamatergic transmission in the striatum. PLoS One 6 e19155 PMID: 21544206
Zhang et al (2011) Desensitization of alpha7 nicotinic receptor is governed by coupling strength relative to gate tightness. J Biol Chem 286 25331 PMID: 21610071
Lozovaya et al (2018) GABAergic inhibition in dual-transmission cholinergic and GABAergic striatal interneurons is abolished in Parkinson disease. Nat Commun 9 1422 PMID: 29651049
Stouffer et al (2015) Insulin enhances striatal dopamine release by activating cholinergic interneurons and thereby signals reward. Nat Commun 6 8543 PMID: 26503322
Assous (2017) Differential processing of thalamic information via distinct striatal interneuron circuits. Nat Commun 8 15860 PMID: 28604688
Do you know of a great paper that uses Mecamylamine hydrochloride from Tocris? Please let us know.
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Literature in this Area
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Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.