Mecamylamine hydrochloride

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Cat.No. 2843 - Mecamylamine hydrochloride | C11H21N.HCl | CAS No. 826-39-1
Description: Non-competitive nicotinic receptor antagonist
Chemical Name: N,2,3,3-Tetramethylbicyclo[2.2.1]heptan-2-amine hydrochloride
Datasheet
Citations (15)
Literature

Biological Activity

Non-competitive nicotinic acetylcholine receptor antagonist. Displays antidepressant-like effects in mice.

Technical Data

M. Wt 203.75
Formula C11H21N.HCl
Storage Desiccate at RT
CAS Number 826-39-1
PubChem ID 13221
InChI Key PKVZBNCYEICAQP-UHFFFAOYSA-N
Smiles CC1(C)C2CCC(C2)C(NC)1C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 15.28 75
water 20.37 100

Preparing Stock Solutions

The following data is based on the product molecular weight 203.75. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.91 mL 24.54 mL 49.08 mL
5 mM 0.98 mL 4.91 mL 9.82 mL
10 mM 0.49 mL 2.45 mL 4.91 mL
50 mM 0.1 mL 0.49 mL 0.98 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Ostroumov et al (2007) Modeling study of mecamylamine block of muscle type acetylcholine receptors. Eur.Biophys.J. 37 393 PMID: 17938901

Rabenstein et al (2006) The nicotinic antagonist mecamylamine has antidepressant-like effects in wild-type but not β2- or α7-nicotinic acetylcholine receptor subunit knockout mice. Psychopharmacol. 189 395 PMID:


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View Related Products by Product Action

View all Nicotinic Receptor (Non-selective) Antagonists

Keywords: Non-competitive nicotinic receptors antagonists Acetylcholine Non-Selective Subtypes nAChR Nicotinic Receptors (Non-selective)

15 Citations for Mecamylamine hydrochloride

Citations are publications that use Tocris products. Selected citations for Mecamylamine hydrochloride include:

Assous (2017) Differential processing of thalamic information via distinct striatal interneuron circuits. Nat Commun 8 15860 PMID: 28604688

Kam et al (2016) Interictal spikes during sleep are an early defect in the Tg2576 mouse model of β-amyloid neuropathology. Proc Natl Acad Sci U S A 6 20119 PMID: 26818394

Herman et al (2016) A cholinergic basal forebrain feeding circuit modulates appetite suppression Nature 538 253 PMID: 27698417

Mamaligas et al (2016) Nicotinic and opioid receptor regulation of striatal dopamine D2-receptor mediated transmission Scientific Reports 6 37834 PMID: 27886263

Stouffer et al (2015) Insulin enhances striatal dopamine release by activating cholinergic interneurons and thereby signals reward. Nat Commun 6 8543 PMID: 26503322

Bryant et al (2015) Cholinergic control of γ power in the midbrain spatial attention network. Elife 35 761 PMID: 25589769

Saunders et al (2015) Corelease of acetylcholine and GABA from cholinergic forebrain neurons. Sci Rep 4 PMID: 25723967

Shin et al (2015) Muscarinic regulation of dopamine and glutamate transmission in the nucleus accumbens. J Neurophysiol 112 8124 PMID: 26080439

Leão et al (2015) Interconnection and synchronization of neuronal populations in the mouse medial septum/diagonal band of Broca. J Neurosci 113 971 PMID: 25392162

Liu et al (2015) Muscarinic receptors modulate dendrodendritic inhibitory synapses to sculpt glomerular output. Front Cell Neurosci 35 5680 PMID: 25855181

Elgueta et al (2015) Acetylcholine induces GABA release onto rod bipolar cells through heteromeric nicotinic receptors expressed in A17 amacrine cells. PLoS One 9 6 PMID: 25709566

Falgairolle and O'Donovan (2015) Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons. Eur J Neurosci 10 e0131430 PMID: 26102354

Costello et al (2014) Comparison of the reinforcing properties of nicotine and cigarette smoke extract in rats. Neuropsychopharmacology 39 1843 PMID: 24513971

Higley et al (2011) Cholinergic interneurons mediate fast VGluT3-dependent glutamatergic transmission in the striatum. PLoS One 6 e19155 PMID: 21544206

Zhang et al (2011) Desensitization of alpha7 nicotinic receptor is governed by coupling strength relative to gate tightness. J Biol Chem 286 25331 PMID: 21610071


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