ME 0328

Discontinued Product

ME 0328 (Cat. No. 5054) has been withdrawn from sale for commercial reasons.
Description: Selective PARP-3 inhibitor
Chemical Name: 3,4-Dihydro-4-oxo-3,4-Dihydro-4-oxo-N-[(1S)-1-phenylethyl]-2-quinazolinepropanamide
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (4)

Biological Activity for ME 0328

ME 0328 is an inhibitor of PARP-3 (IC50 = 0.89 μM). Displays selectivity for PARP-3 over PARP-1, PARP-2 and other ARDT enzymes (IC50 values are 6.3, 10.8 and >30 μM respectively). Enhances CRISPR-Cas9-mediated HER2 mutation frequency, resulting in increased reduction in proliferation of HER2-positive breast cancer cells. Cell permeable.

Technical Data for ME 0328

M. Wt 321.37
Formula C19H19N3O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1445251-22-8
PubChem ID 71571526
InChI Key QIHBWVVVRYYYRO-ZDUSSCGKSA-N
Smiles O=C2NC(CCC(N[C@@H](C)C3=CC=CC=C3)=O)=NC1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for ME 0328

References are publications that support the biological activity of the product.

Lindgren et al (2013) PARP inhibitor with selectivity toward ADP-ribosyltransferase ARTD3/PARP3. ACS Chem.Biol. 8 1698 PMID: 23742272

Wang and Sun (2016) CRISPR-mediated targeting of HER2 inhibits cell proliferation through a dominant negative mutation. Cancer Lett. PMID: 27815036

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Keywords: ME 0328, ME 0328 supplier, ME0328, PARP3, ARDT3, inhibitors, inhibits, selective, CRISPR-Cas9, HER2, Poly(ADP-ribose), Polymerase, CRISPR, Reagents, 5054, Tocris Bioscience

1 Citation for ME 0328

Citations are publications that use Tocris products. Selected citations for ME 0328 include:

Wang and Sun (2016) CRISPR-mediated targeting of HER2 inhibits cell proliferation through a dominant negative mutation. Cancer Letters 385 137 PMID: 27815036


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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