ME 0328

Pricing Availability Delivery Time Qty
Cat.No. 5054 - ME 0328 | C19H19N3O2 | CAS No. 1445251-22-8
Description: Selective PARP-3 inhibitor
Chemical Name: 3,4-Dihydro-4-oxo-3,4-Dihydro-4-oxo-N-[(1S)-1-phenylethyl]-2-quinazolinepropanamide
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Inhibitor of PARP-3 (IC50 = 0.89 μM). Displays selectivity for PARP-3 over PARP-1, PARP-2 and other ARDT enzymes (IC50 values are 6.3, 10.8 and >30 μM respectively). Enhances CRISPR-Cas9-mediated HER2 mutation frequency, resulting in increased reduction in proliferation of HER2-positive breast cancer cells. Cell permeable.

Compound Libraries

ME 0328 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 321.37
Formula C19H19N3O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1445251-22-8
PubChem ID 71571526
InChI Key QIHBWVVVRYYYRO-ZDUSSCGKSA-N
Smiles O=C2NC(CCC(N[C@@H](C)C3=CC=CC=C3)=O)=NC1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 32.14 100

Preparing Stock Solutions

The following data is based on the product molecular weight 321.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.11 mL 15.56 mL 31.12 mL
5 mM 0.62 mL 3.11 mL 6.22 mL
10 mM 0.31 mL 1.56 mL 3.11 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Lindgren et al (2013) PARP inhibitor with selectivity toward ADP-ribosyltransferase ARTD3/PARP3. ACS Chem.Biol. 8 1698 PMID: 23742272

Wang and Sun (2016) CRISPR-mediated targeting of HER2 inhibits cell proliferation through a dominant negative mutation. Cancer Lett. PMID: 27815036


If you know of a relevant reference for ME 0328, please let us know.

View Related Products by Product Action

View all Poly(ADP-Ribose) Polymerase Inhibitors

Keywords: ME0328 PARP3 ARDT3 inhibitors inhibits selective CRISPR-Cas9 HER2 Poly(ADP-ribose) Polymerase

1 Citation for ME 0328

Citations are publications that use Tocris products. Selected citations for ME 0328 include:

Wang and Sun et al (2016) CRISPR-mediated targeting of HER2 inhibits cell proliferation through a dominant negative mutation. Cancer Letters 385 137 PMID: 27815036


Do you know of a great paper that uses ME 0328 from Tocris? If so please let us know.

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
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Cell Cycle & DNA Damage Repair

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.

Pathways for ME 0328

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