ME 0328

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Cat.No. 5054 - ME 0328 | C19H19N3O2 | CAS No. 1445251-22-8
Description: Selective PARP-3 inhibitor
Chemical Name: 3,4-Dihydro-4-oxo-3,4-Dihydro-4-oxo-N-[(1S)-1-phenylethyl]-2-quinazolinepropanamide
Purity: ≥98% (HPLC)
Citations (1)
Literature (3)

Biological Activity for ME 0328

ME 0328 is an inhibitor of PARP-3 (IC50 = 0.89 μM). Displays selectivity for PARP-3 over PARP-1, PARP-2 and other ARDT enzymes (IC50 values are 6.3, 10.8 and >30 μM respectively). Enhances CRISPR-Cas9-mediated HER2 mutation frequency, resulting in increased reduction in proliferation of HER2-positive breast cancer cells. Cell permeable.

Technical Data for ME 0328

M. Wt 321.37
Formula C19H19N3O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1445251-22-8
PubChem ID 71571526
Smiles O=C2NC(CCC(N[C@@H](C)C3=CC=CC=C3)=O)=NC1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ME 0328

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 32.14 100

Preparing Stock Solutions for ME 0328

The following data is based on the product molecular weight 321.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.11 mL 15.56 mL 31.12 mL
5 mM 0.62 mL 3.11 mL 6.22 mL
10 mM 0.31 mL 1.56 mL 3.11 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

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References for ME 0328

References are publications that support the biological activity of the product.

Lindgren et al (2013) PARP inhibitor with selectivity toward ADP-ribosyltransferase ARTD3/PARP3. ACS Chem.Biol. 8 1698 PMID: 23742272

Wang and Sun (2016) CRISPR-mediated targeting of HER2 inhibits cell proliferation through a dominant negative mutation. Cancer Lett. PMID: 27815036

If you know of a relevant reference for ME 0328, please let us know.

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Keywords: ME 0328, ME 0328 supplier, ME0328, PARP3, ARDT3, inhibitors, inhibits, selective, CRISPR-Cas9, HER2, Poly(ADP-ribose), Polymerase, CRISPR, Reagents, 5054, Tocris Bioscience

1 Citation for ME 0328

Citations are publications that use Tocris products. Selected citations for ME 0328 include:

Wang and Sun (2016) CRISPR-mediated targeting of HER2 inhibits cell proliferation through a dominant negative mutation. Cancer Letters 385 137 PMID: 27815036

Do you know of a great paper that uses ME 0328 from Tocris? Please let us know.

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Literature in this Area

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In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.