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Inhibitor of PARP-3 (IC50 = 0.89 μM). Displays selectivity for PARP-3 over PARP-1, PARP-2 and other ARDT enzymes (IC50 values are 6.3, 10.8 and >30 μM respectively). Enhances CRISPR-Cas9-mediated HER2 mutation frequency, resulting in increased reduction in proliferation of HER2-positive breast cancer cells. Cell permeable.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 321.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.11 mL||15.56 mL||31.12 mL|
|5 mM||0.62 mL||3.11 mL||6.22 mL|
|10 mM||0.31 mL||1.56 mL||3.11 mL|
|50 mM||0.06 mL||0.31 mL||0.62 mL|
References are publications that support the biological activity of the product.
Lindgren et al (2013) PARP inhibitor with selectivity toward ADP-ribosyltransferase ARTD3/PARP3. ACS Chem.Biol. 8 1698 PMID: 23742272
Wang and Sun (2016) CRISPR-mediated targeting of HER2 inhibits cell proliferation through a dominant negative mutation. Cancer Lett. PMID: 27815036
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Keywords: ME 0328, ME 0328 supplier, ME0328, PARP3, ARDT3, inhibitors, inhibits, selective, CRISPR-Cas9, HER2, Poly(ADP-ribose), Polymerase, CRISPR, Reagents, 5054, Tocris Bioscience
1 Citation for ME 0328
Citations are publications that use Tocris products. Selected citations for ME 0328 include:
Wang and Sun (2016) CRISPR-mediated targeting of HER2 inhibits cell proliferation through a dominant negative mutation. Cancer Letters 385 137 PMID: 27815036
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Literature in this Area
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Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.