MDL 72222

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Cat.No. 0640 - MDL 72222 | C15H17Cl2NO2 | CAS No. 40796-97-2
Description: 5-HT3 antagonist
Chemical Name: Tropanyl 3,5-dichlorobenzoate
Purity: ≥99% (HPLC)
Datasheet
Citations (6)
Reviews (1)
Literature (2)

Biological Activity

5-HT3 antagonist.

Compound Libraries

MDL 72222 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 314.21
Formula C15H17Cl2NO2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 40796-97-2
PubChem ID 1683
InChI Key MNJNPLVXBISNSX-UHFFFAOYSA-N
Smiles CN1C2CCC1CC(C2)OC(=O)C1=CC(Cl)=CC(Cl)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 100

Preparing Stock Solutions

The following data is based on the product molecular weight 314.21. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.18 mL 15.91 mL 31.83 mL
5 mM 0.64 mL 3.18 mL 6.37 mL
10 mM 0.32 mL 1.59 mL 3.18 mL
50 mM 0.06 mL 0.32 mL 0.64 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Fozard (1984) MDL 72222: a potent and highly selective antagonist at neuronal 5-hydroxytryptamine receptors. Naunyn Schmiedebergs Arch.Pharmacol. 326 36 PMID: 6472484

Richardson and Engel (1986) The pharmacology and function of 5-HT3 receptors. Trends Neurosci. 9 424


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Keywords: MDL 72222, MDL 72222 supplier, 5-HT3, antagonists, Serotonin, Receptors, MDL72222, 0640, Tocris Bioscience

6 Citations for MDL 72222

Citations are publications that use Tocris products. Selected citations for MDL 72222 include:

Bocchio et al (2015) Increased serotonin transporter expression reduces fear and recruitment of parvalbumin interneurons of the amygdala. Neuropsychopharmacology 40 3015 PMID: 26052039

Jinka et al (2012) Inhibition of NMDA-type glutamate receptors induces arousal from torpor in hibernating arctic ground squirrels (Urocitellus parryii). J Neurochem 122 934 PMID: 22697356

Geerts et al (1999) Involvement of 5-HT1B receptors in collar-induced hypersensitivity to 5-hydroxytryptamine of the rabbit carotid artery. Br J Pharmacol 127 1327 PMID: 10455282

Hampson et al (2007) Stimulation of glycogen synthesis and inactivation of phosphorylase in hepatocytes by serotonergic mechanisms, and counter-regulation by atypical antipsychotic drugs. Diabetologia 50 1743 PMID: 17579833


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Reviews for MDL 72222

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Pharmacological block of 5-HT3 receptors.
By Anonymous on 08/31/2019
Assay Type: Ex Vivo
Species: Mouse
Cell Line/Tissue: Cerebellum

MDL 72222 was used for pharmacological isolation of glycine receptors response in nucleated membrane patches pulled from cerebellar granule cells. Clear response was obtained, with characteristic conductance states pertinent to glycine receptor. Picture: recording of single-channel openings of glycine receptor with 10 microM MDL 72222 in perfusion solution.

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Literature in this Area

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Ion Channel

Ion Channel Product Listing

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5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.