MDL 72222

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Cat.No. 0640 - MDL 72222 | C15H17Cl2NO2 | CAS No. 40796-97-2
Description: 5-HT3 antagonist
Chemical Name: Tropanyl 3,5-dichlorobenzoate
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Reviews
Literature

Biological Activity

5-HT3 antagonist.

Compound Libraries

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Technical Data

M. Wt 314.21
Formula C15H17Cl2NO2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 40796-97-2
PubChem ID 1683
InChI Key MNJNPLVXBISNSX-UHFFFAOYSA-N
Smiles CN1C2CCC1CC(C2)OC(=O)C1=CC(Cl)=CC(Cl)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in DMSO

Preparing Stock Solutions

The following data is based on the product molecular weight 314.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.18 mL 15.91 mL 31.83 mL
5 mM 0.64 mL 3.18 mL 6.37 mL
10 mM 0.32 mL 1.59 mL 3.18 mL
50 mM 0.06 mL 0.32 mL 0.64 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Fozard (1984) MDL 72222: a potent and highly selective antagonist at neuronal 5-hydroxytryptamine receptors. Naunyn Schmiedebergs Arch.Pharmacol. 326 36 PMID: 6472484

Richardson and Engel (1986) The pharmacology and function of 5-HT3 receptors. Trends Neurosci. 9 424 PMID:


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Keywords: MDL 72222, supplier, 5-HT3, antagonists, Serotonin, Receptors, MDL72222, 5-HT3, Receptors, 5-HT3, Receptors, Tocris Bioscience

2 Citations for MDL 72222

Citations are publications that use Tocris products. Selected citations for MDL 72222 include:

Bocchio et al (2015) Increased serotonin transporter expression reduces fear and recruitment of parvalbumin interneurons of the amygdala. Neuropsychopharmacology 40 3015 PMID: 26052039

Woo et al (2007) Neuregulin-1 enhances depolarization-induced GABA release. Neuron 54 599 PMID: 17521572


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Literature in this Area

5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.