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Biological Activity for MCL 0020
MCL 0020 is a potent and selective melanocortin MC4 receptor antagonist (IC50 values are 11.63, 1115 and > 10 000 nM at MC4, MC3 and MC1 receptors respectively). Significantly reverses stress-induced anorexia but has no effect on food intake in free-feeding rats. Exhibits anxiolytic-like activity in vivo.
Technical Data for MCL 0020
(Modifications: X-1 = Ac-D-2-Nal, X-3 = 2-Nal & C-terminal amide)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for MCL 0020
|Solubility||Soluble to 2 mg/ml in 25% ethanol / water|
References for MCL 0020
References are publications that support the biological activity of the product.
Chaki et al (2003) Involvement of the melanocortin MC4 receptor in stress-related behavior in rodents. Eur.J.Pharmacol. 474 95 PMID: 12909200
If you know of a relevant reference for MCL 0020, please let us know.
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Keywords: MCL 0020, MCL 0020 supplier, Selective, MC4R, receptor, antagonists, Receptors, Melanocortin, MCL0020, 3438, Tocris Bioscience
Citations for MCL 0020
Citations are publications that use Tocris products.
Currently there are no citations for MCL 0020. Do you know of a great paper that uses MCL 0020 from Tocris? Please let us know.
Reviews for MCL 0020
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.