MCL 0020

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Cat.No. 3438 - MCL 0020 | Ac-D-2-NaI-Arg-2-NaI-NH2 | CAS No. 475498-26-1
Description: Selective MC4 receptor antagonist
Datasheet
Citations

Biological Activity

Potent and selective melanocortin MC4 receptor antagonist (IC50 values are 11.63, 1115 and > 10 000 nM at MC4, MC3 and MC1 receptors respectively). Significantly reverses stress-induced anorexia but has no effect on food intake in free-feeding rats. Exhibits anxiolytic-like activity in vivo.

Technical Data

M. Wt 609.73
Formula C34H39N7O4
Sequence XRX

(Modifications: X-1 = Ac-D-2-Nal, X-3 = 2-Nal & C-terminal amide)

Storage Store at -20°C
CAS Number 475498-26-1
PubChem ID 9938789
InChI Key FJFLYSMWSRRMRO-FRXPANAUSA-N
Smiles CC(=O)N[C@H](CC1=CC2=CC=CC=C2C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](CC1=CC2=CC=CC=C2C=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 2 mg/ml in 25% ethanol / water

Preparing Stock Solutions

The following data is based on the product molecular weight 609.73. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.64 mL 8.2 mL 16.4 mL
5 mM 0.33 mL 1.64 mL 3.28 mL
10 mM 0.16 mL 0.82 mL 1.64 mL
50 mM 0.03 mL 0.16 mL 0.33 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Chaki et al (2003) Involvement of the melanocortin MC4 receptor in stress-related behavior in rodents. Eur.J.Pharmacol. 474 95 PMID: 12909200


If you know of a relevant reference for MCL 0020, please let us know.

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Keywords: Selective MC4R receptor antagonists Receptors Melanocortin MCL0020 Melanocortin (MC) Receptor Peptide

Citations for MCL 0020

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