MCL 0020

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Cat.No. 3438 - MCL 0020 | Ac-D-2-NaI-Arg-2-NaI-NH2 | CAS No. 475498-26-1
Description: Selective MC4 receptor antagonist
Datasheet
Citations
Reviews
Literature (3)

Biological Activity

Potent and selective melanocortin MC4 receptor antagonist (IC50 values are 11.63, 1115 and > 10 000 nM at MC4, MC3 and MC1 receptors respectively). Significantly reverses stress-induced anorexia but has no effect on food intake in free-feeding rats. Exhibits anxiolytic-like activity in vivo.

Technical Data

M. Wt 609.73
Formula C34H39N7O4
Sequence XRX

(Modifications: X-1 = Ac-D-2-Nal, X-3 = 2-Nal & C-terminal amide)

Storage Store at -20°C
CAS Number 475498-26-1
PubChem ID 9938789
InChI Key FJFLYSMWSRRMRO-FRXPANAUSA-N
Smiles CC(=O)N[C@H](CC1=CC2=CC=CC=C2C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](CC1=CC2=CC=CC=C2C=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 2 mg/ml in 25% ethanol / water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Chaki et al (2003) Involvement of the melanocortin MC4 receptor in stress-related behavior in rodents. Eur.J.Pharmacol. 474 95 PMID: 12909200


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Keywords: MCL 0020, MCL 0020 supplier, Selective, MC4R, receptor, antagonists, Receptors, Melanocortin, MCL0020, 3438, Tocris Bioscience

Citations for MCL 0020

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Literature in this Area

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