MB 0223

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Description: Dynamin-related GTPase DRP1 partial inhibitor
Chemical Name: 4-Methyl-1-((2-(piperidin-1-yl)thiazol-4-yl)methyl)-N-(4-(pyridin-3-yl)phenyl)-1H-pyrrole-2-carboxamide
Purity: ≥98% (HPLC)

Biological Activity for MB 0223

MB 0223 is a dynamin-related GTPase DRP1 partial inhibitor (IC50 = 1.2 μM). Selective for DRP1 over other dynamin-related GTPases, OPA1 and DYN1. Increases mitochondrial DNA levels in mfn1- knockout MEFs deficient in mitochondrial fusion.

Technical Data for MB 0223

M. Wt 457.59
Formula C26H27N5OS
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2247732-89-2
PubChem ID 135368613
Smiles CC1=CN(C(C(NC2=CC=C(C3=CN=CC=C3)C=C2)=O)=C1)CC4=CSC(N5CCCCC5)=N4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for MB 0223

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 45.76 100

Preparing Stock Solutions for MB 0223

The following data is based on the product molecular weight 457.59. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.19 mL 10.93 mL 21.85 mL
5 mM 0.44 mL 2.19 mL 4.37 mL
10 mM 0.22 mL 1.09 mL 2.19 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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References for MB 0223

References are publications that support the biological activity of the product.

Mallat et al (2018) Discovery and characterization of selective small molecule inhibitors of the mammalian mitochondrial division dynamin, DRP1. Biochem.Biophys.Res.Commun. 499 556 PMID: 29601815

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Keywords: MB 0223, MB 0223 supplier, MB0223, DRP1, dynamin, related, GTPase, inhibitors, inhibits, partial, mitochondrial, dynamics, division, Dynamin, 6799, Tocris Bioscience

Citations for MB 0223

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