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Biological Activity for MB 0223
MB 0223 is a dynamin-related GTPase DRP1 partial inhibitor (IC50 = 1.2 μM). Selective for DRP1 over other dynamin-related GTPases, OPA1 and DYN1. Increases mitochondrial DNA levels in mfn1- knockout MEFs deficient in mitochondrial fusion.
Technical Data for MB 0223
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for MB 0223
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for MB 0223
The following data is based on the product molecular weight 457.59. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.19 mL||10.93 mL||21.85 mL|
|5 mM||0.44 mL||2.19 mL||4.37 mL|
|10 mM||0.22 mL||1.09 mL||2.19 mL|
|50 mM||0.04 mL||0.22 mL||0.44 mL|
References for MB 0223
References are publications that support the biological activity of the product.
Mallat et al (2018) Discovery and characterization of selective small molecule inhibitors of the mammalian mitochondrial division dynamin, DRP1. Biochem.Biophys.Res.Commun. 499 556 PMID: 29601815
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Keywords: MB 0223, MB 0223 supplier, MB0223, DRP1, dynamin, related, GTPase, inhibitors, inhibits, partial, mitochondrial, dynamics, division, Dynamin, 6799, Tocris Bioscience
Citations for MB 0223
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