MB 0223

Pricing Availability   Qty
Description: Dynamin-related GTPase DRP1 partial inhibitor
Chemical Name: 4-Methyl-1-((2-(piperidin-1-yl)thiazol-4-yl)methyl)-N-(4-(pyridin-3-yl)phenyl)-1H-pyrrole-2-carboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews

Biological Activity for MB 0223

MB 0223 is a dynamin-related GTPase DRP1 partial inhibitor (IC50 = 1.2 μM). Selective for DRP1 over other dynamin-related GTPases, OPA1 and DYN1. Increases mitochondrial DNA levels in mfn1- knockout MEFs deficient in mitochondrial fusion.

Technical Data for MB 0223

M. Wt 457.59
Formula C26H27N5OS
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2247732-89-2
PubChem ID 135368613
InChI Key SWLKFZCOJAYAMJ-UHFFFAOYSA-N
Smiles CC1=CN(C(C(NC2=CC=C(C3=CN=CC=C3)C=C2)=O)=C1)CC4=CSC(N5CCCCC5)=N4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for MB 0223

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 45.76 100

Preparing Stock Solutions for MB 0223

The following data is based on the product molecular weight 457.59. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.19 mL 10.93 mL 21.85 mL
5 mM 0.44 mL 2.19 mL 4.37 mL
10 mM 0.22 mL 1.09 mL 2.19 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for MB 0223

References are publications that support the biological activity of the product.

Mallat et al (2018) Discovery and characterization of selective small molecule inhibitors of the mammalian mitochondrial division dynamin, DRP1. Biochem.Biophys.Res.Commun. 499 556 PMID: 29601815


If you know of a relevant reference for MB 0223, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Dynamin Inhibitors

Keywords: MB 0223, MB 0223 supplier, MB0223, DRP1, dynamin, related, GTPase, inhibitors, inhibits, partial, mitochondrial, dynamics, division, Dynamin, 6799, Tocris Bioscience

Citations for MB 0223

Citations are publications that use Tocris products.

Currently there are no citations for MB 0223. Do you know of a great paper that uses MB 0223 from Tocris? Please let us know.

Reviews for MB 0223

There are currently no reviews for this product. Be the first to review MB 0223 and earn rewards!

Have you used MB 0223?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review