M62812

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Cat.No. 5705 - M62812 | C13H11N3OS.2HCl | CAS No. 613263-00-6
Description: TLR-4 inhibitor
Chemical Name: 6-(2-Aminophenoxy)-1,2-benzisothiazol-3-amine dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature
Pathways

Biological Activity

TLR4 inhibitor. Inhibits LPS-induced NF-κB activation in HEK293 cells (IC50 = 2.4 μg/mL). Also inhibits LPS-induced cytokine production and procoagulant effects in PBMCs and HUVECs. Prolongs survival in a mouse septic shock model.

Technical Data

M. Wt 330.23
Formula C13H11N3OS.2HCl
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 613263-00-6
PubChem ID 44224214
InChI Key SMTKPLISDFNJDJ-UHFFFAOYSA-N
Smiles NC1=CC=CC=C1OC2=CC=C3C(SN=C3N)=C2.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 16.51 50
water 33.02 100

Preparing Stock Solutions

The following data is based on the product molecular weight 330.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.03 mL 15.14 mL 30.28 mL
5 mM 0.61 mL 3.03 mL 6.06 mL
10 mM 0.3 mL 1.51 mL 3.03 mL
50 mM 0.06 mL 0.3 mL 0.61 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Nakamura et al (2007) Toll-like receptor 4 signal transduction inhibitor, M62812, suppresses endothelial cell and leukocyte activation and prevents lethal septic shock in mice. Eur.J.Pharmacol. 569 237 PMID: 17588563


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Keywords: M62812, supplier, Toll-like, receptors, inhibits, inhibitors, TLR-4, sepsis, septic, shock, Toll-like, Receptors, Toll-like, Receptors, Tocris Bioscience

Citations for M62812

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Literature in this Area

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Pathways for M62812

Toll-like Receptor

Toll-like Receptor Signaling Pathway

TLR signaling is involved in the cellular response to threatening molecules such as bacteria and viruses. It results in an inflammatory and immmunological response.