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Biological Activity for M62812
M62812 is a TLR4 inhibitor. Inhibits LPS-induced NF-κB activation in HEK293 cells (IC50 = 2.4 μg/mL). Also inhibits LPS-induced cytokine production and procoagulant effects in PBMCs and HUVECs. Prolongs survival in a mouse septic shock model.
Compound Libraries for M62812
Technical Data for M62812
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for M62812
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for M62812
The following data is based on the product molecular weight 330.23. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.03 mL||15.14 mL||30.28 mL|
|5 mM||0.61 mL||3.03 mL||6.06 mL|
|10 mM||0.3 mL||1.51 mL||3.03 mL|
|50 mM||0.06 mL||0.3 mL||0.61 mL|
References for M62812
References are publications that support the biological activity of the product.
Nakamura et al (2007) Toll-like receptor 4 signal transduction inhibitor, M62812, suppresses endothelial cell and leukocyte activation and prevents lethal septic shock in mice. Eur.J.Pharmacol. 569 237 PMID: 17588563
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Keywords: M62812, M62812 supplier, Toll-like, receptors, inhibits, inhibitors, TLR-4, sepsis, septic, shock, Receptors, 5705, Tocris Bioscience
2 Citations for M62812
Citations are publications that use Tocris products. Selected citations for M62812 include:
Nara et al (2020) TAP2, a peptide antagonist of Toll-like receptor 4, attenuates pain and cartilage degradation in a monoiodoacetate-induced arthritis rat model. Sci Rep 10 17451 PMID: 33060735
Jing et al (2020) Mucosal Vaccination for Influenza Protection Enhanced by Catalytic Immune-Adjuvant. Adv Sci (Weinh) 7 2000771 PMID: 32999833
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Reviews for M62812
Average Rating: 3 (Based on 1 Review.)
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Literature in this Area
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