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Submit ReviewM62812 is a TLR4 inhibitor. Inhibits LPS-induced NF-κB activation in HEK293 cells (IC50 = 2.4 μg/mL). Also inhibits LPS-induced cytokine production and procoagulant effects in PBMCs and HUVECs. Prolongs survival in a mouse septic shock model.
M62812 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.
M. Wt | 330.23 |
Formula | C13H11N3OS.2HCl |
Storage | Store at +4°C |
Purity | ≥98% (HPLC) |
CAS Number | 613263-00-6 |
PubChem ID | 44224214 |
InChI Key | SMTKPLISDFNJDJ-UHFFFAOYSA-N |
Smiles | NC1=CC=CC=C1OC2=CC=C3C(SN=C3N)=C2.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
water | 33.02 | 100 | |
DMSO | 16.51 | 50 |
The following data is based on the product molecular weight 330.23. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 3.03 mL | 15.14 mL | 30.28 mL |
5 mM | 0.61 mL | 3.03 mL | 6.06 mL |
10 mM | 0.3 mL | 1.51 mL | 3.03 mL |
50 mM | 0.06 mL | 0.3 mL | 0.61 mL |
References are publications that support the biological activity of the product.
Nakamura et al (2007) Toll-like receptor 4 signal transduction inhibitor, M62812, suppresses endothelial cell and leukocyte activation and prevents lethal septic shock in mice. Eur.J.Pharmacol. 569 237 PMID: 17588563
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Keywords: M62812, M62812 supplier, Toll-like, receptors, inhibits, inhibitors, TLR-4, sepsis, septic, shock, Receptors, 5705, Tocris Bioscience
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Average Rating: 3 (Based on 1 Review.)
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