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Lys-[Des-Arg9]Bradykinin is an endogenous potent and highly selective bradykinin B1 receptor agonist (Ki values are 0.12 and > 30000 nM at human B1 and B2 receptors respectively). Hypotensive agent that reduces peripheral vascular resistance in vivo. 16-fold more potent than [Des-Arg9]-Bradykinin (Cat No. 3005).
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble to 1 mg/ml in water|
References are publications that support the biological activity of the product.
Drapeau et al (1991) Hypotensive effects of Lys-des-Arg9-Bradykinin and metabolically protected agonists of B1 receptors for kinins. J.Pharmacol.Exp.Ther. 259 997 PMID: 1662280
Regoli et al (2001) Classification of kinin receptors. Biol.Chem. 382 31 PMID: 11258668
Leeb-Lundberg et al (2005) International union of pharmacology. LV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Pharmacol.Rev. 57 27 PMID: 15734727
If you know of a relevant reference for Lys-[Des-Arg9]Bradykinin, please let us know.
Keywords: Lys-[Des-Arg9]Bradykinin, Lys-[Des-Arg9]Bradykinin supplier, Selective, B1, agonists, Receptors, Bradykinin, Des-Arg10-Kallidin, 3225, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for Lys-[Des-Arg9]Bradykinin include:
Brailoiu (2017) Modulation of cardiac vagal tone by bradykinin acting on nucleus ambiguus. Neuroscience 365 23 PMID: 28951324
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