Lys-[Des-Arg9]Bradykinin

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Cat.No. 3225 - Lys-[Des-Arg9]Bradykinin | Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe | CAS No. 71800-36-7
Description: Selective B1 agonist
Alternative Names: Des-Arg10-Kallidin
Datasheet
Citations
Literature

Biological Activity

Endogenous potent and highly selective bradykinin B1 receptor agonist (Ki values are 0.12 and > 30000 nM at human B1 and B2 receptors respectively). Hypotensive agent that reduces peripheral vascular resistance in vivo. 16-fold more potent than [Des-Arg9]-Bradykinin (Cat No. 3005).

Technical Data

M. Wt 1032.21
Formula C50H73N13O11
Sequence KRPPGFSPF
Storage Desiccate at -20°C
CAS Number 71800-36-7
PubChem ID 122227
InChI Key AILVBOHFGXNHCC-TZPCGENMSA-N
Smiles [H]N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1032.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.97 mL 4.84 mL 9.69 mL
5 mM 0.19 mL 0.97 mL 1.94 mL
10 mM 0.1 mL 0.48 mL 0.97 mL
50 mM 0.02 mL 0.1 mL 0.19 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Drapeau et al (1991) Hypotensive effects of Lys-des-Arg9-Bradykinin and metabolically protected agonists of B1 receptors for kinins. J.Pharmacol.Exp.Ther. 259 997 PMID: 1662280

Regoli et al (2001) Classification of kinin receptors. Biol.Chem. 382 31 PMID: 11258668

Leeb-Lundberg et al (2005) International union of pharmacology. LV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Pharmacol.Rev. 57 27 PMID: 15734727


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Keywords: Lys-[Des-Arg9]Bradykinin, supplier, Selective, B1, agonists, Receptors, Bradykinin, Des-Arg10-Kallidin, Bradykinin, Receptors, Bradykinin, Receptors, Tocris Bioscience

Citations for Lys-[Des-Arg9]Bradykinin

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