[Des-Arg9]-Bradykinin

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Cat.No. 3005 - [Des-Arg9]-Bradykinin | Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe | CAS No. 15958-92-6
Description: Bradykinin receptor agonist (B1 > B2)
Alternative Names: Bradykinin (1-8)
Datasheet
Citations
Literature

Biological Activity

Bradykinin receptor agonist that displays selectivity for B1 over B2 receptors.

Technical Data

M. Wt 904.03
Formula C44H61N11O10
Sequence RPPGFSPF
Storage Desiccate at -20°C
CAS Number 15958-92-6
PubChem ID 105044
InChI Key VCEHWDBVPZFHAG-POFDKVPJSA-N
Smiles N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 0.90 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 904.03. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.11 mL 5.53 mL 11.06 mL
5 mM 0.22 mL 1.11 mL 2.21 mL
10 mM 0.11 mL 0.55 mL 1.11 mL
50 mM 0.02 mL 0.11 mL 0.22 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Regoli et al (1998) Bradykinin receptors and their antagonists. Eur.J.Pharmacol. 348 1 PMID: 9650825

Leeb-Lundberg et al (2005) International union of pharmacology XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Pharmacol.Rev. 57 27 PMID: 15734727

Abraham et al (2006) Peptide and non-peptide bradykinin receptor antagonists: role in allergic airway disease. Eur.J.Pharmacol. 533 215 PMID: 16455073


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