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Cat.No. 5103 - Lys-CoA | C31H53N10O19P3S.C2HF3O2
Description: Selective p300 inhibitor
Chemical Name: S-[2-[[(5S)-5-(Acetylamino)-6-amino-6-oxohexyl]amino]-2-oxoethyl]coenzyme A trifluoroacetate
Purity: ≥95% (HPLC)
Literature (3)

Biological Activity for Lys-CoA

Lys-CoA is a selective p300 histone acetyltransferase (HAT) inhibitor (IC50 = 50-500 nM). Exhibits approximately 100-fold selectivity for p300 over PCAF (IC50 = 200 μM). Inhibits p300-dependent transcription. Active in vivo.

Technical Data for Lys-CoA

M. Wt 1108.82
Formula C31H53N10O19P3S.C2HF3O2
Storage Store at -20°C
Purity ≥95% (HPLC)
Smiles O[C@H]([C@@H]1OP(O)(O)=O)[C@@H](O[C@@H]1COP(OP(OCC(C)(C)[C@@H](O)C(NCCC(NCCSCC(NCCCC[C@@H](C(N)=O)NC(C)=O)=O)=O)=O)(O)=O)(O)=O)N2C3=NC=NC(N)=C3N=C2.OC(C(F)(F)F)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Lys-CoA

Solvent Max Conc. mg/mL Max Conc. mM
water 6.99 6.3

Preparing Stock Solutions for Lys-CoA

The following data is based on the product molecular weight 1108.82. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.063 mM 14.32 mL 71.58 mL 143.15 mL
0.315 mM 2.86 mL 14.32 mL 28.63 mL
0.63 mM 1.43 mL 7.16 mL 14.32 mL
3.15 mM 0.29 mL 1.43 mL 2.86 mL

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References for Lys-CoA

References are publications that support the biological activity of the product.

Lau et al (2000) HATs off: selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF. Mol.Cell. 5 589 PMID: 10882143

Liu et al (2008) The structural basis of protein acetylation by the p300/CBP transcriptional coactivator. Nature. 451 846 PMID: 18273021

Burns et al (2005) Iso-coenzyme A. J.Biol.Chem. 280 16550 PMID: 15708855

Cebrat et al (2003) Synthesis and analysis of potential prodrugs of coenzyme A analogues for the inhibition of the histone acetyltransferase p300. Bioorg.Med.Chem. 11 3307 PMID: 12837541

If you know of a relevant reference for Lys-CoA, please let us know.

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Keywords: Lys-CoA, Lys-CoA supplier, Lys-CoA, p300, histone, acetyltransferase, inhibitors, inhibits, HAT, selective, active, in, vivo, Histone, Acetyltransferases, Post-translational, Modifications, 5103, Tocris Bioscience

Citations for Lys-CoA

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