Selective p300 histone acetyltransferase (HAT) inhibitor (IC50 = 50-500 nM). Exhibits approximately 100-fold selectivity for p300 over PCAF (IC50 = 200 μM). Inhibits p300-dependent transcription. Active in vivo.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 1108.82. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.9 mL||4.51 mL||9.02 mL|
|5 mM||0.18 mL||0.9 mL||1.8 mL|
|10 mM||0.09 mL||0.45 mL||0.9 mL|
|50 mM||0.02 mL||0.09 mL||0.18 mL|
References are publications that support the products' biological activity.
Lau et al (2000) HATs off: selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF. Mol.Cell. 5 589 PMID: 10882143
Liu et al (2008) The structural basis of protein acetylation by the p300/CBP transcriptional coactivator. Nature. 451 846 PMID: 18273021
Burns et al (2005) Iso-coenzyme A. J.Biol.Chem. 280 16550 PMID: 15708855
Cebrat et al (2003) Synthesis and analysis of potential prodrugs of coenzyme A analogues for the inhibition of the histone acetyltransferase p300. Bioorg.Med.Chem. 11 3307 PMID: 12837541
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Keywords: Lys-CoA, supplier, Lys-CoA, p300, histone, acetyltransferase, inhibitors, inhibits, HAT, selective, active, in, vivo, Histone, Acetyltransferases, Post-translational, Modifications, Histone, Acetyltransferases, Tocris Bioscience
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