Discontinued Product

Lys-CoA (Cat. No. 5103) has been withdrawn from sale for commercial reasons.
Description: Selective p300 inhibitor
Chemical Name: S-[2-[[(5S)-5-(Acetylamino)-6-amino-6-oxohexyl]amino]-2-oxoethyl]coenzyme A trifluoroacetate
Purity: ≥95% (HPLC)
Literature (1)

Biological Activity for Lys-CoA

Lys-CoA is a selective p300 histone acetyltransferase (HAT) inhibitor (IC50 = 50-500 nM). Exhibits approximately 100-fold selectivity for p300 over PCAF (IC50 = 200 μM). Inhibits p300-dependent transcription. Active in vivo.

Technical Data for Lys-CoA

M. Wt 1108.82
Formula C31H53N10O19P3S.C2HF3O2
Storage Store at -20°C
Purity ≥95% (HPLC)
Smiles O[C@H]([C@@H]1OP(O)(O)=O)[C@@H](O[C@@H]1COP(OP(OCC(C)(C)[C@@H](O)C(NCCC(NCCSCC(NCCCC[C@@H](C(N)=O)NC(C)=O)=O)=O)=O)(O)=O)(O)=O)N2C3=NC=NC(N)=C3N=C2.OC(C(F)(F)F)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for Lys-CoA

References are publications that support the biological activity of the product.

Lau et al (2000) HATs off: selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF. Mol.Cell. 5 589 PMID: 10882143

Liu et al (2008) The structural basis of protein acetylation by the p300/CBP transcriptional coactivator. Nature. 451 846 PMID: 18273021

Burns et al (2005) Iso-coenzyme A. J.Biol.Chem. 280 16550 PMID: 15708855

Cebrat et al (2003) Synthesis and analysis of potential prodrugs of coenzyme A analogues for the inhibition of the histone acetyltransferase p300. Bioorg.Med.Chem. 11 3307 PMID: 12837541

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Keywords: Lys-CoA, Lys-CoA supplier, Lys-CoA, p300, histone, acetyltransferase, inhibitors, inhibits, HAT, selective, active, in, vivo, Histone, Acetyltransferases, Post-translational, Modifications, 5103, Tocris Bioscience

Citations for Lys-CoA

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Currently there are no citations for Lys-CoA.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Epigenetics Scientific Review

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.