Endogenous bradykinin receptor agonist that displays some selectivity for the B2 receptor (Ki values are 2.54 and 0.63 nM at human B1 and B2 receptors respectively). Hypotensive agent that reduces peripheral vascular resistance in vivo. Twice as potent as bradykinin (Cat No. 3004) in vivo.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 5 mg/ml in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 1188.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.84 mL||4.21 mL||8.41 mL|
|5 mM||0.17 mL||0.84 mL||1.68 mL|
|10 mM||0.08 mL||0.42 mL||0.84 mL|
|50 mM||0.02 mL||0.08 mL||0.17 mL|
References are publications that support the biological activity of the product.
Regoli and Barabe (1980) Pharmacology of bradykinin and related kinins. Pharmacol.Rev. 32 1 PMID: 7015371
Regoli et al (2001) Classification of kinin receptors. Biol.Chem. 382 31 PMID: 11258668
Leeb-Lundberg et al (2005) International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Pharmacol.Rev. 57 27 PMID: 15734727
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Keywords: Lys-Bradykinin, Lys-Bradykinin supplier, Potent, bradykinin, receptor, agonists, B2, B1, Receptors, Kallidin, Bradykinin, 3227, Tocris Bioscience
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