Lyn peptide inhibitor

Pricing Availability   Qty
Cat.No. 2265 - Lyn peptide inhibitor | Octadecanoyl-Tyr-Gly-Tyr-Arg-Leu-Arg-Arg-Lys-Trp-Glu-Glu-Lys-Ile-Pro-Asn-Pro-NH2 | CAS No. 222018-18-0
Description: Inhibits Lyn-dependent activities of IL-5 receptor; cell-permeable
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Cell-permeable inhibitor of Lyn-dependent effects of the IL-5 receptor. Blocks binding of Lyn tyrosine kinase to βc subunit of IL-3/GM-CSF/IL-5 receptors, blocking Lyn activation. Inhibits IL-5 receptor-mediated eosinophil differentiation and survival in vitro. Inhibits airway eosinophilic inflammation in mouse model of asthma.

Technical Data

M. Wt 2370.91
Formula C115H184N30O24
Sequence YGYRLRRKWEEKIPNP

(Modifications: Tyr-1 = Octadecanoyl-Tyr, Pro-16 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 222018-18-0
PubChem ID 90001265
InChI Key MITSVNFZLBORMW-QMGLJYLZSA-N
Smiles CCCCCCCCCCCCCCCCCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 10 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Adachi et al (1999) The mapping of the Lyn kinase binding site of the common β subunit of IL-3/granulocyte-macrophage colony-stimulating factor/IL-5 receptor. J.Immunol. 162 1496 PMID: 9973406

Adachi et al (1999) A novel lyn-binding peptide inhibitor blocks eosinophil differentiation, survival, and airway eosinophilic inflammation. J.Immunol. 163 939 PMID: 10395690


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Keywords: Lyn peptide inhibitor, Lyn peptide inhibitor supplier, inhibitors, inhibits, Lyn, activation, IL-5, receptor, IL-3, Src, kinases, IL, receptors, Interleukin, cytokine, Cytokine, Receptors, Kinases, 2265, Tocris Bioscience

1 Citation for Lyn peptide inhibitor

Citations are publications that use Tocris products. Selected citations for Lyn peptide inhibitor include:

Zhang et al (2018) Integrin CD11b negatively regulates Mincle-induced signaling via the Lyn-SIRPα-SHP1 complex. Exp Mol Med 50 e439 PMID: 29400702


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