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Submit ReviewLyn peptide inhibitor
Description: Inhibits Lyn-dependent activities of IL-5 receptor; cell-permeable
Biological Activity
Cell-permeable inhibitor of Lyn-dependent effects of the IL-5 receptor. Blocks binding of Lyn tyrosine kinase to βc subunit of IL-3/GM-CSF/IL-5 receptors, blocking Lyn activation. Inhibits IL-5 receptor-mediated eosinophil differentiation and survival in vitro. Inhibits airway eosinophilic inflammation in mouse model of asthma.
Technical Data
| M. Wt | 2370.91 |
| Formula | C115H184N30O24 |
| Sequence |
YGYRLRRKWEEKIPNP (Modifications: Tyr-1 = Octadecanoyl-Tyr, Pro-16 = C-terminal amide) |
| Storage | Desiccate at -20°C |
| CAS Number | 222018-18-0 |
| PubChem ID | 90001265 |
| InChI Key | MITSVNFZLBORMW-QMGLJYLZSA-N |
| Smiles | CCCCCCCCCCCCCCCCCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solubility | Soluble to 10 mg/ml in water |
Product Datasheets
References
References are publications that support the biological activity of the product.
Adachi et al (1999) The mapping of the Lyn kinase binding site of the common β subunit of IL-3/granulocyte-macrophage colony-stimulating factor/IL-5 receptor. J.Immunol. 162 1496 PMID: 9973406
Adachi et al (1999) A novel lyn-binding peptide inhibitor blocks eosinophil differentiation, survival, and airway eosinophilic inflammation. J.Immunol. 163 939 PMID: 10395690
If you know of a relevant reference for Lyn peptide inhibitor, please let us know.
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Keywords: Lyn peptide inhibitor, Lyn peptide inhibitor supplier, inhibitors, inhibits, Lyn, activation, IL-5, receptor, IL-3, Src, kinases, IL, receptors, Interleukin, cytokine, Cytokine, Receptors, Kinases, 2265, Tocris Bioscience
1 Citation for Lyn peptide inhibitor
Citations are publications that use Tocris products. Selected citations for Lyn peptide inhibitor include:
Zhang et al (2018) Integrin CD11b negatively regulates Mincle-induced signaling via the Lyn-SIRPα-SHP1 complex. Exp Mol Med 50 e439 PMID: 29400702
Do you know of a great paper that uses Lyn peptide inhibitor from Tocris? Please let us know.
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