Lyn peptide inhibitor
Biological Activity
Cell-permeable inhibitor of Lyn-dependent effects of the IL-5 receptor. Blocks binding of Lyn tyrosine kinase to βc subunit of IL-3/GM-CSF/IL-5 receptors, blocking Lyn activation. Inhibits IL-5 receptor-mediated eosinophil differentiation and survival in vitro. Inhibits airway eosinophilic inflammation in mouse model of asthma.
Technical Data
| M. Wt | 2370.91 |
| Formula | C115H184N30O24 |
| Sequence |
YGYRLRRKWEEKIPNP (Modifications: Tyr-1 = Octadecanoyl-Tyr, Pro-16 = C-terminal amide) |
| Storage | Desiccate at -20°C |
| CAS Number | 222018-18-0 |
| PubChem ID | 90001265 |
| InChI Key | MITSVNFZLBORMW-QMGLJYLZSA-N |
| Smiles | CCCCCCCCCCCCCCCCCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 10 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 2370.91. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.42 mL | 2.11 mL | 4.22 mL |
| 5 mM | 0.08 mL | 0.42 mL | 0.84 mL |
| 10 mM | 0.04 mL | 0.21 mL | 0.42 mL |
| 50 mM | 0.01 mL | 0.04 mL | 0.08 mL |
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References
References are publications that support the products' biological activity.
Adachi et al (1999) The mapping of the Lyn kinase binding site of the common β subunit of IL-3/granulocyte-macrophage colony-stimulating factor/IL-5 receptor. J.Immunol. 162 1496 PMID: 9973406
Adachi et al (1999) A novel lyn-binding peptide inhibitor blocks eosinophil differentiation, survival, and airway eosinophilic inflammation. J.Immunol. 163 939 PMID: 10395690
If you know of a relevant reference for Lyn peptide inhibitor, please let us know.
View Related Products by Target
Keywords: inhibitors inhibits Lyn activation IL-5 receptor IL-3 Src kinases IL receptors Interleukin cytokine Cytokine Receptors
Citations for Lyn peptide inhibitor
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