LY 334370 hydrochloride

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Cat.No. 3079 - LY 334370 hydrochloride | C21H22FN3O.HCl | CAS No. 199673-74-0
Description: Selective 5-HT1F agonist
Chemical Name: 4-Fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]benzamide hydrochloride
Purity: ≥99% (HPLC)
Citations (1)
Literature (2)

Biological Activity for LY 334370 hydrochloride

LY 334370 hydrochloride is a selective 5-HT1F receptor agonist (Ki values are 1.87, 16.4, > 100 (IC50), 176, 189, 281, 1280, 1530, 1550, > 3000 (IC50) and 3250 nM for 5-HT1F, 5-HT1A, 5-HT4, 5-HT1E, 5-HT1B, 5-HT1D, 5-HT2B, 5-HT2A, 5-HT7, 5-HT6 and 5-HT2C receptors respectively). Displays antimigraine effects.

Licensing Information

Sold under license from Eli Lilly and company

Technical Data for LY 334370 hydrochloride

M. Wt 387.88
Formula C21H22FN3O.HCl
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 199673-74-0
PubChem ID 19710026
Smiles O=C(C4=CC=C(F)C=C4)NC1=CC=C(NC=C2C3CCN(C)CC3)C2=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for LY 334370 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 9.7 25 with gentle warming
DMSO 9.7 25 with gentle warming

Preparing Stock Solutions for LY 334370 hydrochloride

The following data is based on the product molecular weight 387.88. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 10.31 mL 51.56 mL 103.12 mL
1.25 mM 2.06 mL 10.31 mL 20.62 mL
2.5 mM 1.03 mL 5.16 mL 10.31 mL
12.5 mM 0.21 mL 1.03 mL 2.06 mL

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Product Datasheets for LY 334370 hydrochloride

Certificate of Analysis / Product Datasheet
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References for LY 334370 hydrochloride

References are publications that support the biological activity of the product.

Dupuis et al (1998) G-protein activationat 5-HT1A receptors by the 5-ht1F ligand LY334370 in guinea-pig brain sections and recombinant cell lines. Br.J.Pharmacol. 124 283 PMID: 9641544

Shepheard et al (1999) Possible antimigraine mechanisms of action of the 5-HT1F receptor agonist LY334370. Cephalalgia 19 851 PMID: 10668103

Wainscott et al (2005) [H3]LY334370, a novel radioligand for the 5-HT1F receptor. I. In vitro characterization of binding properties. Naunyn-Schmied.Arch.Pharmacol. 371 169

If you know of a relevant reference for LY 334370 hydrochloride, please let us know.

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1 Citation for LY 334370 hydrochloride

Citations are publications that use Tocris products. Selected citations for LY 334370 hydrochloride include:

Garrett et al (2014) Agonism of the 5-hydroxytryptamine 1F receptor promotes mitochondrial biogenesis and recovery from acute kidney injury. J Pharmacol Exp Ther 350 257 PMID: 24849926

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Literature in this Area

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5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.