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LY 334370 hydrochloride
Discontinued ProductLY 334370 hydrochloride (Cat. No. 3079) has been withdrawn from sale for commercial reasons.
Biological Activity for LY 334370 hydrochloride
LY 334370 hydrochloride is a selective 5-HT1F receptor agonist (Ki values are 1.87, 16.4, > 100 (IC50), 176, 189, 281, 1280, 1530, 1550, > 3000 (IC50) and 3250 nM for 5-HT1F, 5-HT1A, 5-HT4, 5-HT1E, 5-HT1B, 5-HT1D, 5-HT2B, 5-HT2A, 5-HT7, 5-HT6 and 5-HT2C receptors respectively). Displays antimigraine effects.
Sold under license from Eli Lilly and company
Technical Data for LY 334370 hydrochloride
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for LY 334370 hydrochloride
References for LY 334370 hydrochloride
References are publications that support the biological activity of the product.
Dupuis et al (1998) G-protein activationat 5-HT1A receptors by the 5-ht1F ligand LY334370 in guinea-pig brain sections and recombinant cell lines. Br.J.Pharmacol. 124 283 PMID: 9641544
Shepheard et al (1999) Possible antimigraine mechanisms of action of the 5-HT1F receptor agonist LY334370. Cephalalgia 19 851 PMID: 10668103
Wainscott et al (2005) [H3]LY334370, a novel radioligand for the 5-HT1F receptor. I. In vitro characterization of binding properties. Naunyn-Schmied.Arch.Pharmacol. 371 169
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Keywords: LY 334370 hydrochloride, LY 334370 hydrochloride supplier, Selective, 5-HT1F, agonists, Serotonin, Receptors, LY334370, hydrochloride, 3079, Tocris Bioscience
1 Citation for LY 334370 hydrochloride
Citations are publications that use Tocris products. Selected citations for LY 334370 hydrochloride include:
Garrett et al (2014) Agonism of the 5-hydroxytryptamine 1F receptor promotes mitochondrial biogenesis and recovery from acute kidney injury. J Pharmacol Exp Ther 350 257 PMID: 24849926
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.