LY 333531 hydrochloride

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Cat.No. 4738 - LY 333531 hydrochloride | C28H28N4O3.HCl | CAS No. 169939-93-9
Description: Protein kinase C inhibitor; selective for β isozymes
Alternative Names: Ruboxistaurin
Chemical Name: (9S)-9-[(Dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione hydrochloride
Citations (3)
Literature (3)

Biological Activity

Isozyme-selective inhibitor of protein kinase C (PKC); competitively and reversibly inhibits PKCβI and PKCβII (IC50 values are 4.7 and 5.9 nM respectively). Selective for PKCβ over other PKC isozymes (IC50 values are 0.052, 0.25, 0.30, 0.36, 0.60 and >100 μM for PKCη, -δ, -γ, -α, -ε and -ζ respectively). Exhibits selectivity for PKC over other ATP-dependent kinases, including protein kinase A, casein kinase and src).

Technical Data

M. Wt 505.01
Formula C28H28N4O3.HCl
Storage Store at -20°C
CAS Number 169939-93-9
PubChem ID 9870785
Smiles O=C(C(C4=CN(CCO[C@H](CN(C)C)CC6)C5=C4C=CC=C5)=C1C2=CN6C3=CC=CC=C23)NC1=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 10.1 20

Preparing Stock Solutions

The following data is based on the product molecular weight 505.01. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

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Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 9.9 mL 49.5 mL 99.01 mL
1 mM 1.98 mL 9.9 mL 19.8 mL
2 mM 0.99 mL 4.95 mL 9.9 mL
10 mM 0.2 mL 0.99 mL 1.98 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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3 Citations for LY 333531 hydrochloride

Citations are publications that use Tocris products. Selected citations for LY 333531 hydrochloride include:

Muellner et al (2015) Targeting a cell state common to triple-negative breast cancers. ASN Neuro 11 789 PMID: 25699542

Ezell et al (2016) Differential regulation of mTOR signaling determines sensitivity to AKT inhibition in diffuse large B cell lymphoma. Oncotarget 7 9163 PMID: 26824321

Cosgrove (2016) N-cadherin adhesive interactions modulate matrix mechanosensing and fate commitment of mesenchymal stem cells. Nature Materials 15 1297 PMID: 27525568

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Literature in this Area

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