You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for LW 6
LW 6 is a malate dehydrogenase-2 (MDH2) inhibitor (IC50 = 6.3 μM). Also inhibits HIF-1α. Prevents accumulation of HIF-1α in Hep3B cells under hypoxic conditions (IC50 = 2.6 μM) with resulting decrease in expression of HIF-1α target genes VEGF and EPO. Inhibits proliferation of activated human T cells ex vivo.
Compound Libraries for LW 6
Technical Data for LW 6
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for LW 6
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for LW 6
The following data is based on the product molecular weight 435.51. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||4.59 mL||22.96 mL||45.92 mL|
|2.5 mM||0.92 mL||4.59 mL||9.18 mL|
|5 mM||0.46 mL||2.3 mL||4.59 mL|
|25 mM||0.09 mL||0.46 mL||0.92 mL|
References for LW 6
References are publications that support the biological activity of the product.
Eleftheriadis et al (2015) Malate dehydrogenase-2 inhibitor LW6 promotes metabolic adaptations and reduces proliferation and apoptosis in activated human T-cells. Exp.Ther.Med. 5 1959 PMID: 26640580
Lee et al (2007) (Aryloxyacetylamino)benzoic acid analogues: A new class of hypoxia-inducible factor-1 inhibitors. J.Med.Chem. 50 1675 PMID: 17328532
Ban et al (2016) A novel malate dehydrogenase 2 inhibitor suppresses hypoxia-inducible factor-1 by regulating mitochondrial respiration. PLoS One 9 e0162568 PMID: 27611801
If you know of a relevant reference for LW 6, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: LW 6, LW 6 supplier, LW6, Malate, dehydrogenase-2, MDH2, inhibitor, inhibitors, inhibits, HIF-1alfa, HIF-1alpha, HIF-1a, hypoxia, inducible, factor, CAY10585, CAY, 10585, Other, Dehydrogenases, Hypoxia, Inducible, Factors, 6322, Tocris Bioscience
Citations for LW 6
Citations are publications that use Tocris products.
Currently there are no citations for LW 6. Do you know of a great paper that uses LW 6 from Tocris? Please let us know.
Reviews for LW 6
There are currently no reviews for this product. Be the first to review LW 6 and earn rewards!
Have you used LW 6?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cancer Metabolism Research Product GuideNew
This product guide reviews some of the main areas in cancer metabolism research and lists around 150 products that can be used to investigate metabolic pathways in cancer including:
- Tricarboxylic Acid Cycle
- 1C Metabolism and Nucleic Acid Synthesis
- Drivers of Metabolic Reprogramming
- pH and Redox Balance
Cancer Metabolism Poster
This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.