You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
LW 6 New
Malate dehydrogenase-2 (MDH2) inhibitor (IC50 = 6.3 μM). Also inhibits HIF-1α. Prevents accumulation of HIF-1α in Hep3B cells under hypoxic conditions (IC50 = 2.6 μM) with resulting decrease in expression of HIF-1α target genes VEGF and EPO. Inhibits proliferation of activated human T cells ex vivo.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 435.51. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||4.59 mL||22.96 mL||45.92 mL|
|2.5 mM||0.92 mL||4.59 mL||9.18 mL|
|5 mM||0.46 mL||2.3 mL||4.59 mL|
|25 mM||0.09 mL||0.46 mL||0.92 mL|
References are publications that support the biological activity of the product.
Eleftheriadis et al (2015) Malate dehydrogenase-2 inhibitor LW6 promotes metabolic adaptations and reduces proliferation and apoptosis in activated human T-cells. Exp.Ther.Med. 5 1959 PMID: 26640580
Lee et al (2007) (Aryloxyacetylamino)benzoic acid analogues: A new class of hypoxia-inducible factor-1 inhibitors. J.Med.Chem. 50 1675 PMID: 17328532
Ban et al (2016) A novel malate dehydrogenase 2 inhibitor suppresses hypoxia-inducible factor-1 by regulating mitochondrial respiration. PLoS One 9 e0162568 PMID: 27611801
If you know of a relevant reference for LW 6, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: LW 6, LW 6 supplier, LW6, Malate, dehydrogenase-2, MDH2, inhibitor, inhibitors, inhibits, HIF-1alfa, HIF-1alpha, HIF-1a, hypoxia, inducible, factor, CAY10585, CAY, 10585, Other, Dehydrogenases, Hypoxia, Inducible, Factors, 6322, Tocris Bioscience
Citations for LW 6
Citations are publications that use Tocris products.
Currently there are no citations for LW 6. Do you know of a great paper that uses LW 6 from Tocris? Please let us know.
Reviews for LW 6
There are currently no reviews for this product. Be the first to review LW 6 and earn rewards!
Have you used LW 6?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
New Product Guide [Spring/Summer 2019]
Our new product guide highlights over 215 new products added to the Tocris Bioscience range during the first half of 2019.
- 7-TM Receptors
- Enzyme-Linked Receptors
- Ion Channels
- Nuclear Receptors
- Fluorescent Imaging
- Signal Transduction
- Stem Cells