LP 922056

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Description: Notum inhibitor; activates Wnt signaling
Chemical Name: 2-[(6-Chloro-7-cyclopropylthieno[3,2-d]pyrimidin-4-yl)thio]acetic acid
Purity: ≥98% (HPLC)

Biological Activity for LP 922056

LP 922056 is a notum pectinacetylesterase inhibitor. LP 922056 activates wnt signaling in vitro (EC50 values are 21 nM in human and 55 nM in mouse cell-based assay). It increases cortical bone thickness in mouse model of bone growth. LP 922056 also inhibits growth of Apc-mutant cell lines and proliferation of intestinal adenomas in vivo.

Compound Libraries for LP 922056

LP 922056 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for LP 922056

M. Wt 300.78
Formula C11H9ClN2O2S2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1365060-22-5
PubChem ID 56932967
Smiles OC(CSC1=C2SC(Cl)=C(C2=NC=N1)C3CC3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for LP 922056

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 30.08 100

Preparing Stock Solutions for LP 922056

The following data is based on the product molecular weight 300.78. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.32 mL 16.62 mL 33.25 mL
5 mM 0.66 mL 3.32 mL 6.65 mL
10 mM 0.33 mL 1.66 mL 3.32 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

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Product Datasheets for LP 922056

Certificate of Analysis / Product Datasheet
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References for LP 922056

References are publications that support the biological activity of the product.

Tarver et al (2016) Stimulation of cortical bone formation with thienopyrimidine based inhibitors of Notum Pectinacetylesterase. Bioorg.Med.Chem.Lett 26 1525 PMID: 26897593

Brommage et al (2019) NOTUM inhibition increases endocortical bone formation and bone strength. Bone Res. 7 PMID: 30622831

Flanagan et al (2021) NOTUM from Apc-mutant cells biases clonal competition to initiate cancer. Nature 594 430 PMID: 34079124

If you know of a relevant reference for LP 922056, please let us know.

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Citations for LP 922056

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