LP 44

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Cat.No. 2534 - LP 44 | C27H37N3OS.HCl | CAS No. 824958-12-5
Description: High affinity 5-HT7 agonist
Chemical Name: 4-[2-(Methylthio)phenyl]-N-(1,2,3,4-tetrahydro-1-naphthalenyl)-1-piperazinehexanamide hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

High affinity 5-HT7 receptor agonist (Ki = 0.22 nM) that displays selectivity over 5-HT1A and 5-HT2A receptors (200- and > 1000-fold respectively). Induces relaxation of substance P-stimulated guinea pig ileum (EC50 = 2.56 μM).

Licensing Information

Sold under license from the University of Bari

Technical Data

M. Wt 488.13
Formula C27H37N3OS.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 824958-12-5
PubChem ID 11225543
InChI Key DWGKCWWWKHCVDH-UHFFFAOYSA-N
Smiles O=C(CCCCCN3CCN(C4=C(SC)C=CC=C4)CC3)NC1CCCC2=C1C=CC=C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 48.81 100
ethanol 36.61 75

Preparing Stock Solutions

The following data is based on the product molecular weight 488.13. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.05 mL 10.24 mL 20.49 mL
5 mM 0.41 mL 2.05 mL 4.1 mL
10 mM 0.2 mL 1.02 mL 2.05 mL
50 mM 0.04 mL 0.2 mL 0.41 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Leopoldo et al (2004) Structure-affinity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinealkylamides, a new class of 5-hydroxytryptamine7 receptor agents. J.Med.Chem. 47 6616 PMID: 15588097


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Keywords: LP 44, supplier, High, affinity, 5-HT7, agonists, Serotonin, Receptors, 5-Hydroxytryptamine, LP44, 5-HT7, Receptors, Tocris Bioscience

1 Citation for LP 44

Citations are publications that use Tocris products. Selected citations for LP 44 include:

Watts et al (2015) 5-HT is a potent relaxant in rat superior mesenteric veins. Mol Med 3 e00103 PMID: 25692021


Do you know of a great paper that uses LP 44 from Tocris? If so please let us know.

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Literature in this Area

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5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

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Pathways for LP 44

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