LP 20 hydrochloride

Discontinued Product

LP 20 hydrochloride (Cat. No. 4704) has been withdrawn from sale for commercial reasons.
Cat.No. 4704 - LP 20 hydrochloride | C17H20N2O.HCl | CAS No. 1386928-34-2
Description: Selective 5-HT7 ligand
Chemical Name: 1-(4'-Methoxy[1,1-biphenyl]-2-yl)piperazine hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Ligand of the 5-HT7 receptor (Ki = 2.6 nM); exhibits agonist and antagonist activity. Displays selectivity over adrenergic α1 and 5-HT1A receptors (Ki values are 156 and 476 nM respectively).

Licensing Information

Sold under license from the University of Bari

Technical Data

M. Wt 304.81
Formula C17H20N2O.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 1386928-34-2
PubChem ID 22001617
InChI Key KXZUJPBDJNUNCN-UHFFFAOYSA-N
Smiles COC(C=C3)=CC=C3C1=CC=CC=C1N2CCNCC2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

References

References are publications that support the biological activity of the product.

Lacivita et al (2012) Investigations on the 1-(2-biphenyl)piperazine motif: identification of new potent and selective ligands for the serotonin7 (5-HT7) receptor with agonist or antagonist action in vitro or ex vivo. J.Med.Chem. 55 6375 PMID: 22738316

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

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