LP 20 hydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 4704 - LP 20 hydrochloride | C17H20N2O.HCl | CAS No. 1386928-34-2
Description: Selective 5-HT7 ligand
Chemical Name: 1-(4'-Methoxy[1,1-biphenyl]-2-yl)piperazine hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Ligand of the 5-HT7 receptor (Ki = 2.6 nM); exhibits agonist and antagonist activity. Displays selectivity over adrenergic α1 and 5-HT1A receptors (Ki values are 156 and 476 nM respectively).

Licensing Information

Sold under license from the University of Bari

Technical Data

M. Wt 304.81
Formula C17H20N2O.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 1386928-34-2
PubChem ID 22001617
InChI Key KXZUJPBDJNUNCN-UHFFFAOYSA-N
Smiles COC(C=C3)=CC=C3C1=CC=CC=C1N2CCNCC2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.48 100
water 15.24 50

Preparing Stock Solutions

The following data is based on the product molecular weight 304.81. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.28 mL 16.4 mL 32.81 mL
5 mM 0.66 mL 3.28 mL 6.56 mL
10 mM 0.33 mL 1.64 mL 3.28 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Lacivita et al (2012) Investigations on the 1-(2-biphenyl)piperazine motif: identification of new potent and selective ligands for the serotonin7 (5-HT7) receptor with agonist or antagonist action in vitro or ex vivo. J.Med.Chem. 55 6375 PMID: 22738316


If you know of a relevant reference for LP 20 hydrochloride, please let us know.

View Related Products by Target

Keywords: LP20 5-HT7 ligands selective serotonergics 5-HT7 Receptors

Citations for LP 20 hydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for LP 20 hydrochloride. Do you know of a great paper that uses LP 20 hydrochloride from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Cardiovascular

Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.

Depression

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

Pathways for LP 20 hydrochloride

Protocols

TODO: Add Protocols