LP 20 hydrochloride

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Cat.No. 4704 - LP 20 hydrochloride | C17H20N2O.HCl | CAS No. 1386928-34-2
Description: Selective 5-HT7 ligand
Chemical Name: 1-(4'-Methoxy[1,1-biphenyl]-2-yl)piperazine hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Ligand of the 5-HT7 receptor (Ki = 2.6 nM); exhibits agonist and antagonist activity. Displays selectivity over adrenergic α1 and 5-HT1A receptors (Ki values are 156 and 476 nM respectively).

Licensing Information

Sold under license from the University of Bari

Technical Data

M. Wt 304.81
Formula C17H20N2O.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 1386928-34-2
PubChem ID 22001617
InChI Key KXZUJPBDJNUNCN-UHFFFAOYSA-N
Smiles COC(C=C3)=CC=C3C1=CC=CC=C1N2CCNCC2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.48 100
water 15.24 50

Preparing Stock Solutions

The following data is based on the product molecular weight 304.81. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.28 mL 16.4 mL 32.81 mL
5 mM 0.66 mL 3.28 mL 6.56 mL
10 mM 0.33 mL 1.64 mL 3.28 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Lacivita et al (2012) Investigations on the 1-(2-biphenyl)piperazine motif: identification of new potent and selective ligands for the serotonin7 (5-HT7) receptor with agonist or antagonist action in vitro or ex vivo. J.Med.Chem. 55 6375 PMID: 22738316


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Literature in this Area

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5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

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