LP 12 hydrochloride

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Cat.No. 2925 - LP 12 hydrochloride | C32H39N3O.HCl | CAS No. 1185136-22-4
Description: 5-HT7 agonist
Chemical Name: 4-(2-Diphenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazinehexanamide hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

5-HT7 receptor agonist displaying selectivity over D2, 5-HT1A and 5-HT2A receptors (Ki values are 0.22, 7.3, 52.7 and 326 nM respectively). Induces relaxation of substance P-induced contractions in guinea pig ileum (EC50 = 1.77 μM).

Licensing Information

Sold under license from the University of Bari

Technical Data

M. Wt 518.13
Formula C32H39N3O.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 1185136-22-4
PubChem ID 56972187
InChI Key XNDUOTNYUWDFKR-UHFFFAOYSA-N
Smiles O=C(CCCCCN3CCN(C4=C(C5=CC=CC=C5)C=CC=C4)CC3)NC2CCCC1=CC=CC=C12.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 38.86 75
ethanol 38.86 75

Preparing Stock Solutions

The following data is based on the product molecular weight 518.13. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.93 mL 9.65 mL 19.3 mL
5 mM 0.39 mL 1.93 mL 3.86 mL
10 mM 0.19 mL 0.97 mL 1.93 mL
50 mM 0.04 mL 0.19 mL 0.39 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Leopoldo et al (2007) Structure-activity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides, a class of 5-HT7 receptor agents. J.Med.Chem. 50 4214 PMID: 17649988


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