You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
LP 12 hydrochloride
Discontinued ProductLP 12 hydrochloride (Cat. No. 2925) has been withdrawn from sale for commercial reasons.
Biological Activity for LP 12 hydrochloride
5-HT7 receptor agonist displaying selectivity over D2, 5-HT1A and 5-HT2A receptors (Ki values are 0.22, 7.3, 52.7 and 326 nM respectively). Induces relaxation of substance P-induced contractions in guinea pig ileum (EC50 = 1.77 μM).
Sold under license from the University of Bari
Technical Data for LP 12 hydrochloride
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for LP 12 hydrochloride
References for LP 12 hydrochloride
References are publications that support the biological activity of the product.
Leopoldo et al (2007) Structure-activity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides, a class of 5-HT7 receptor agents. J.Med.Chem. 50 4214 PMID: 17649988
View Related Products by Product Action
Keywords: LP 12 hydrochloride, LP 12 hydrochloride supplier, 5-HT7, agonists, Serotonin, Receptors, 5-Hydroxytryptamine, LP12, hydrochloride, 2925, Tocris Bioscience
Citations for LP 12 hydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for LP 12 hydrochloride.
Reviews for LP 12 hydrochloride
There are currently no reviews for this product. Be the first to review LP 12 hydrochloride and earn rewards!
Have you used LP 12 hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.