LP 12 hydrochloride

Discontinued Product

LP 12 hydrochloride (Cat. No. 2925) has been withdrawn from sale for commercial reasons.
Cat.No. 2925 - LP 12 hydrochloride | C32H39N3O.HCl | CAS No. 1185136-22-4
Description: 5-HT7 agonist
Chemical Name: 4-(2-Diphenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazinehexanamide hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

5-HT7 receptor agonist displaying selectivity over D2, 5-HT1A and 5-HT2A receptors (Ki values are 0.22, 7.3, 52.7 and 326 nM respectively). Induces relaxation of substance P-induced contractions in guinea pig ileum (EC50 = 1.77 μM).

Licensing Information

Sold under license from the University of Bari

Technical Data

M. Wt 518.13
Formula C32H39N3O.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 1185136-22-4
PubChem ID 56972187
InChI Key XNDUOTNYUWDFKR-UHFFFAOYSA-N
Smiles O=C(CCCCCN3CCN(C4=C(C5=CC=CC=C5)C=CC=C4)CC3)NC2CCCC1=CC=CC=C12.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References

References are publications that support the biological activity of the product.

Leopoldo et al (2007) Structure-activity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides, a class of 5-HT7 receptor agents. J.Med.Chem. 50 4214 PMID: 17649988

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Citations for LP 12 hydrochloride

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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