LLY 507

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Cat.No. 5365 - LLY 507 | C36H42N6O | CAS No. 1793053-37-8
Description: Potent SMYD2 inhibitor
Chemical Name: 3-Cyano-5-[2-[4-[2-(3-methyl-1H-indol-1-yl)ethyl]piperazin-1-yl]phenyl]-N-[3-(pyrrolidin-1-yl)propyl]benzamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent SMYD2 inhibitor (IC50 = 15 nM). Exhibits >100-fold selectivity for SMYD2 over 25 other methyltransferases including SMYD3, SUV420H1 and SUV420H2. Inhibits SMYD2-mediated p53 methylation in vitro. Also inhibits proliferation of a range of esophageal, liver and breast cancer cell lines.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the LLY 507 probe summary on the SGC website.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of LLY 507 is reviewed on the chemical probes website.

Technical Data

M. Wt 574.76
Formula C36H42N6O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1793053-37-8
PubChem ID 91623361
InChI Key PNYRDVBFYVDJJI-UHFFFAOYSA-N
Smiles CC(C5=C4C=CC=C5)=CN4CCN(CC3)CCN3C1=C(C2=CC(C#N)=CC(C(NCCCN6CCCC6)=O)=C2)C=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 57.48 100
DMSO 57.48 100

Preparing Stock Solutions

The following data is based on the product molecular weight 574.76. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.74 mL 8.7 mL 17.4 mL
5 mM 0.35 mL 1.74 mL 3.48 mL
10 mM 0.17 mL 0.87 mL 1.74 mL
50 mM 0.03 mL 0.17 mL 0.35 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Nguyen et al (2015) LLY-507, a cell-active, potent, and selective inhibitor of protein-lysine methyltransferase SMYD2. J.Biol.Chem. 290 13641 PMID: 25825497


If you know of a relevant reference for LLY 507, please let us know.

View Related Products by Product Action

View all Other Lysine Methyltransferase Inhibitors

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Citations for LLY 507

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Literature in this Area

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