LLY 507

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Cat.No. 5365 - LLY 507 | C36H42N6O | CAS No. 1793053-37-8
Description: Potent SMYD2 inhibitor
Chemical Name: 3-Cyano-5-[2-[4-[2-(3-methyl-1H-indol-1-yl)ethyl]piperazin-1-yl]phenyl]-N-[3-(pyrrolidin-1-yl)propyl]benzamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent SMYD2 inhibitor (IC50 = 15 nM). Exhibits >100-fold selectivity for SMYD2 over 25 other methyltransferases including SMYD3, SUV420H1 and SUV420H2. Inhibits SMYD2-mediated p53 methylation in vitro. Also inhibits proliferation of a range of esophageal, liver and breast cancer cell lines.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the LLY 507 probe summary on the SGC website.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of LLY 507 is reviewed on the chemical probes website.

Technical Data

M. Wt 574.76
Formula C36H42N6O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1793053-37-8
PubChem ID 91623361
InChI Key PNYRDVBFYVDJJI-UHFFFAOYSA-N
Smiles CC(C5=C4C=CC=C5)=CN4CCN(CC3)CCN3C1=C(C2=CC(C#N)=CC(C(NCCCN6CCCC6)=O)=C2)C=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 57.48 100
DMSO 57.48 100
ethanol 57.48 100

Preparing Stock Solutions

The following data is based on the product molecular weight 574.76. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.74 mL 8.7 mL 17.4 mL
5 mM 0.35 mL 1.74 mL 3.48 mL
10 mM 0.17 mL 0.87 mL 1.74 mL
50 mM 0.03 mL 0.17 mL 0.35 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Nguyen et al (2015) LLY-507, a cell-active, potent, and selective inhibitor of protein-lysine methyltransferase SMYD2. J.Biol.Chem. 290 13641 PMID: 25825497


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Keywords: LLY507 potent selective SMYD2 inhibitors inhibits lysine methyltransferases p53 Lysine Methyltransferases

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Epigenetics

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.

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