Lisuride maleate

Pricing Availability Delivery Time Qty
Cat.No. 4052 - Lisuride maleate | C20H26N4O.C4H4O4 | CAS No. 19875-60-6
Description: DA receptor agonist; antiparkinson's agent.
Chemical Name: N'-[(8α)-9,10-Didehydro-6-methylergolin-8-yl]-N,N-diethylurea maleate
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Dopamine receptor agonist and anti-Parkinson's agent. Displays high affinity for D2, D3 and D4 receptors along with 5-HT1A. Exhibits some 5-HT2B receptor antagonist properties. Decreases prolactin release; reduces inflammatory mediators such as TNF-α and IL6. Exhibits anticonvulsive effects. Acts similar to bromocriptine (Cat. No. 0427).

Technical Data

M. Wt 454.52
Formula C20H26N4O.C4H4O4
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 19875-60-6
PubChem ID 5282421
InChI Key CVQFAMQDTWVJSV-BAXNFHPCSA-N
Smiles OC(/C=C\C(O)=O)=O.[H][C@@]1(C2)C(C3=C4C2=CNC4=CC=C3)=C[C@H](NC(N(CC)CC)=O)CN1C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 44.66 100
ethanol 2.23 5
water 2.23 5mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 454.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.2 mL 11 mL 22 mL
5 mM 0.44 mL 2.2 mL 4.4 mL
10 mM 0.22 mL 1.1 mL 2.2 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Hofmann et al (2006) Lisuride, a dopamine receptor agonist with 5-HT2B receptor antagonist properties: absence of cardiac valvulopathy adverse drug reaction reports supports the concept of a crucial role for 5-HT2B receptor agonism in cardiac valvular fi Clin.Neuropharmacol. 29 80 PMID: 16614540

Zweckberger et al (2010) Anticonvulsive effects of the dopamine agonist lisuride maleate after experimental traumatic brain injury. Neurosci.Lett. 470 150 PMID: 20056133

Woitalla et al (2004) Transdermal lisuride delivery in the treatment of Parkinson's disease. J.Neural Transm. 68 89 PMID:


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Keywords: antiparkinsonian drug anti-Parkinson's disease dopaminergic agonists dopamine receptor agonist DA Non-selective Dopamine

Citations for Lisuride maleate

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Pathways for Lisuride maleate

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