Linomide

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Cat.No. 1461 - Linomide | C18H16N2O3 | CAS No. 84088-42-6
Description: Immunomodulator with antiangiogenic properties
Chemical Name: 1,2-Dihydro-4-hydroxy-N,N-dimethyl-2-oxo-N-phenyl-3-quinolinecarboxamide
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Immunomodulator with stimulatory and antitumor properties. Inhibits in vivo apoptosis of T cells and inhibits angiogenesis in rats in vivo.

Technical Data

M. Wt 308.33
Formula C18H16N2O3
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 84088-42-6
PubChem ID 54676478
InChI Key SGOOQMRIPALTEL-UHFFFAOYSA-N
Smiles CN(C(=O)C1=C(O)C2=CC=CC=C2N(C)C1=O)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1.1eq. NaOH 30.83 100

Preparing Stock Solutions

The following data is based on the product molecular weight 308.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.24 mL 16.22 mL 32.43 mL
5 mM 0.65 mL 3.24 mL 6.49 mL
10 mM 0.32 mL 1.62 mL 3.24 mL
50 mM 0.06 mL 0.32 mL 0.65 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Gonzalo et al (1994) Linomide inhibits programmed cell death of peripheral T cells in vivo. Eur.J.Immunol. 24 48 PMID: 8020570

Ichikawa et al (1992) The antitumor effects of the quinoline-3-carboxamide linomide on Dunning R-3327 rat prostatic cancers. Cancer Res. 52 3022 PMID: 1591718

Vukanovic et al (1993) Antiangiogenic effects of the quinoline-3-carboxamide linomide. Cancer Res. 53 1833 PMID: 7682157


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Keywords: Linomide, Linomide supplier, Immunomodulators, antiangiogenics, Antiangiogenics, 1461, Tocris Bioscience

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Cancer

Cancer Research Product Guide

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Angiogenesis in Cancer

Angiogenesis in Cancer Poster

Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.