LG 101506

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Cat.No. 3508 - LG 101506 | C25H34F2O3 | CAS No. 331248-11-4
Description: Selective RXR modulator
Alternative Names: LG 1506
Chemical Name: (2E,4E,6Z)-7-[2-(2,2-Difluoroethoxy)-3,5-bis(1,1-dimethylethyl)phenyl]-3-methyl-2,4,6-octatrienoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Selective RXR modulator (Ki values are 3, 9 and 11 for RXRα, RXRβ and RXRγ respectively). Displays poor binding affinity for RAR isoforms (Ki values are 2746, 3516 and >10,000 nM for RARα, RARβ and RARγ respectively). Binding to RXR results in selective activation of RXR:PPARγ, RXR:PPARα and RXR:PPARδ heterodimers.

Technical Data

M. Wt 420.53
Formula C25H34F2O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 331248-11-4
PubChem ID 9845057
InChI Key BHIBZAZKKARFIM-XRYBSMBUSA-N
Smiles CC(C)(C)C1=CC(/C(C)=C\C=C\C(C)=C\C(O)=O)=C(OCC(F)F)C(C(C)(C)C)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 42.05 100
ethanol 21.03 50

Preparing Stock Solutions

The following data is based on the product molecular weight 420.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.38 mL 11.89 mL 23.78 mL
5 mM 0.48 mL 2.38 mL 4.76 mL
10 mM 0.24 mL 1.19 mL 2.38 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

Molarity Calculator

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Reconstitution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Michellys et al (2003) Novel (2E,4E,6Z)-7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta-2,4,6-trienoic acid retinoid X receptor modulators are active in models of type 2 diabetes. J.Med.Chem. 46 2683 PMID: 12801232

Leibowitz et al (2006) Biological characterization of a heterodimer-selective retinoid X receptor modulator: potential benefits for the treatment of type 2 diabetes. Endocrinology 147 1044 PMID: 16269450

Pinaire et al (2007) Therapeutic potential of retinoid X receptor modulators for the treatment of the metabolic syndrome. PPAR Res. 94156 PMID: 17497022


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1 Citation for LG 101506

Citations are publications that use Tocris products. Selected citations for LG 101506 include:

Ronn et al (2015) Retinoic Acid regulates hematopoietic development from human pluripotent stem cells. Development 4 269 PMID: 25680478


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