LF 11

Pricing Availability Delivery Time Qty
Cat.No. 4421 - LF 11 | Phe-Gln-Trp-Gln-Arg-Asn-Ile-Arg-Lys-Val-Arg-NH2 | CAS No. 832729-13-2
Description: Antibiotic; neutralizes LPS
Datasheet
Citations
Literature

Biological Activity

Peptide based on the lipopolysaccharide (LPS)-binding region of human lactoferricin. Neutralizes LPS; displays antimicrobial activity against Gram-negative and Gram-positive bacteria. Analog lauryl-LF 11 (Cat. No. 4422) available.

Technical Data

M. Wt 1529.81
Formula C69H112N26O14
Sequence FQWQRNIRKVR

(Modifications: Arg-11 = C-terminal amide)

Storage Store at -20°C
CAS Number 832729-13-2
PubChem ID 25089955
InChI Key SIROSQHTQDVQTI-JDJCIBPGSA-N
Smiles [H]N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 2 mg/ml in 20% acetonitrile / water

Preparing Stock Solutions

The following data is based on the product molecular weight 1529.81. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.65 mL 3.27 mL 6.54 mL
5 mM 0.13 mL 0.65 mL 1.31 mL
10 mM 0.07 mL 0.33 mL 0.65 mL
50 mM 0.01 mL 0.07 mL 0.13 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Sanchez-Gomez et al (2008) Comparative analysis of selected methods for the assessment of antimicrobial and membrane-permeabilizing activity: a case study for lactoferricin derived peptides. BMC Mirobiol. 11 196 PMID: 19014450

Japelj et al (2005) Structural origin of endotoxin neutralization and antimicrobial activity of a lactoferrin-based peptide. J.Biol.Chem. 280 16955 PMID: 15687491

Andra et al (2005) Enhancement of endotoxin neutralization by coupling of a C12-alkyl chain to a lactoferricin-derived peptide. Biochem.J. 385 135 PMID: 15344905


If you know of a relevant reference for LF 11, please let us know.

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Keywords: LF 11, supplier, LF11, lps, lipopolysaccharide, lactoferricin, antimicrobial, peptide, antibiotics, Antibiotics, Tocris Bioscience

Citations for LF 11

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New Product Guide (Spring/Summer 2017)

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Pathways for LF 11

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