LF 11

Pricing Availability Delivery Time Qty
Cat.No. 4421 - LF 11 | Phe-Gln-Trp-Gln-Arg-Asn-Ile-Arg-Lys-Val-Arg-NH2 | CAS No. 832729-13-2
Description: Antibiotic; neutralizes LPS
Datasheet
Citations
Reviews
Literature

Biological Activity

Peptide based on the lipopolysaccharide (LPS)-binding region of human lactoferricin. Neutralizes LPS; displays antimicrobial activity against Gram-negative and Gram-positive bacteria. Analog lauryl-LF 11 (Cat. No. 4422) available.

Technical Data

M. Wt 1529.81
Formula C69H112N26O14
Sequence FQWQRNIRKVR

(Modifications: Arg-11 = C-terminal amide)

Storage Store at -20°C
CAS Number 832729-13-2
PubChem ID 25089955
InChI Key SIROSQHTQDVQTI-JDJCIBPGSA-N
Smiles [H]N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 2 mg/ml in 20% acetonitrile / water

Preparing Stock Solutions

The following data is based on the product molecular weight 1529.81. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.65 mL 3.27 mL 6.54 mL
5 mM 0.13 mL 0.65 mL 1.31 mL
10 mM 0.07 mL 0.33 mL 0.65 mL
50 mM 0.01 mL 0.07 mL 0.13 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Sanchez-Gomez et al (2008) Comparative analysis of selected methods for the assessment of antimicrobial and membrane-permeabilizing activity: a case study for lactoferricin derived peptides. BMC Mirobiol. 11 196 PMID: 19014450

Japelj et al (2005) Structural origin of endotoxin neutralization and antimicrobial activity of a lactoferrin-based peptide. J.Biol.Chem. 280 16955 PMID: 15687491

Andra et al (2005) Enhancement of endotoxin neutralization by coupling of a C12-alkyl chain to a lactoferricin-derived peptide. Biochem.J. 385 135 PMID: 15344905


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Keywords: LF 11, supplier, LF11, lps, lipopolysaccharide, lactoferricin, antimicrobial, peptide, antibiotics, Antibiotics, Antibiotics, Tocris Bioscience

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Literature in this Area

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