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Submit ReviewLF 11
Description: Antibiotic; neutralizes LPS
Biological Activity
Peptide based on the lipopolysaccharide (LPS)-binding region of human lactoferricin. Neutralizes LPS; displays antimicrobial activity against Gram-negative and Gram-positive bacteria. Analog lauryl-LF 11 (Cat. No. 4422) available.
Technical Data
| M. Wt | 1529.81 |
| Formula | C69H112N26O14 |
| Sequence |
FQWQRNIRKVR (Modifications: Arg-11 = C-terminal amide) |
| Storage | Store at -20°C |
| CAS Number | 832729-13-2 |
| PubChem ID | 25089955 |
| InChI Key | SIROSQHTQDVQTI-JDJCIBPGSA-N |
| Smiles | [H]N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solubility | Soluble to 2 mg/ml in 20% acetonitrile / water |
Product Datasheets
References
References are publications that support the biological activity of the product.
Sanchez-Gomez et al (2008) Comparative analysis of selected methods for the assessment of antimicrobial and membrane-permeabilizing activity: a case study for lactoferricin derived peptides. BMC Mirobiol. 11 196 PMID: 19014450
Japelj et al (2005) Structural origin of endotoxin neutralization and antimicrobial activity of a lactoferrin-based peptide. J.Biol.Chem. 280 16955 PMID: 15687491
Andra et al (2005) Enhancement of endotoxin neutralization by coupling of a C12-alkyl chain to a lactoferricin-derived peptide. Biochem.J. 385 135 PMID: 15344905
If you know of a relevant reference for LF 11, please let us know.
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Keywords: LF 11, LF 11 supplier, LF11, lps, lipopolysaccharide, lactoferricin, antimicrobial, peptide, antibiotics, Antibiotics, 4421, Tocris Bioscience
Citations for LF 11
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Reviews for LF 11
Average Rating: 5 (Based on 1 Review.)
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Highly resistant E.Coli produced through gene transfer were subjected to LF 11.
By
Anonymous on 12/13/2018
Species: Human
Highly resistant E.Coli produced through gene transfer were subjected to LF 11 and few other antibiotics to assess the antimicrobial activity over the resistant strains.The percentage inhibition over time was determined by disc diffusion and broth dilution methods.
