Biological Activity
N-terminally acylated analog of LF 11 (Cat. No. 4421). Displays enhanced antibacterial and LPS-binding activities.
Technical Data
| M. Wt | 1712.11 |
| Formula | C81H134N26O15 |
| Sequence |
FQWQRNIRKVR (Modifications: Phe-1 = CH3-(CH2)10-CO-NH-Phe, Arg-11 = C-terminal amide) |
| Storage | Store at -20°C |
| CAS Number | 832729-14-3 |
| PubChem ID | 90488941 |
| InChI Key | AUHGQKBFMDAWAQ-BSHYLFJSSA-N |
| Smiles | CCCCCCCCCCCNC(CC1CCCCC1)C(O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)CN[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 2 mg/ml in 30% acetonitrile / water |
Preparing Stock Solutions
The following data is based on the product molecular weight 1712.11. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.58 mL | 2.92 mL | 5.84 mL |
| 5 mM | 0.12 mL | 0.58 mL | 1.17 mL |
| 10 mM | 0.06 mL | 0.29 mL | 0.58 mL |
| 50 mM | 0.01 mL | 0.06 mL | 0.12 mL |
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Product Datasheets
References
References are publications that support the biological activity of the product.
Zweytick et al (2006) Influence of N-acylation of a peptide derived from human lactoferricin on membrane selectivity. Biochim.Biophys.Acta 1758 1426 PMID: 16616888
Rosenfeld et al (2010) Effect of the hydrophobicity to net positive charge ratio on antibacterial and anti-endotoxin activities of structurally similar antimicrobial peptides. Biochemistry 49 853 PMID: 20058937
Andra et al (2005) Enhancement of endotoxin neutralization by coupling of a C12-alkyl chain to a lactoferricin-derived peptide. Biochem.J. 385 135 PMID: 15344905
If you know of a relevant reference for Lauryl-LF 11, please let us know.
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Keywords: Lauryl-LF 11, Lauryl-LF 11 supplier, lauryl-LF11, lps, lipopolysaccharide, lactoferricin, antimicrobial, peptides, antibiotics, Antibiotics, 4422, Tocris Bioscience
Citations for Lauryl-LF 11
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