Lauryl-LF 11

Pricing Availability Delivery Time Qty
Cat.No. 4422 - Lauryl-LF 11 | CH3-(CH2)10-CO-NH-Phe-Gln-Trp-Gln-Arg-Asn-Ile-Arg-Lys-Val-Arg-NH2 | CAS No. 832729-14-3
Description: Analog of LF 11 (Cat. No. 4421); antibiotic
Datasheet
Citations
Literature

Biological Activity

N-terminally acylated analog of LF 11 (Cat. No. 4421). Displays enhanced antibacterial and LPS-binding activities.

Technical Data

M. Wt 1712.11
Formula C81H134N26O15
Sequence FQWQRNIRKVR

(Modifications: Phe-1 = CH3-(CH2)10-CO-NH-Phe, Arg-11 = C-terminal amide)

Storage Store at -20°C
CAS Number 832729-14-3
PubChem ID 90488941
InChI Key AUHGQKBFMDAWAQ-BSHYLFJSSA-N
Smiles CCCCCCCCCCCNC(CC1CCCCC1)C(O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)CN[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 2 mg/ml in 30% acetonitrile / water

Preparing Stock Solutions

The following data is based on the product molecular weight 1712.11. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.58 mL 2.92 mL 5.84 mL
5 mM 0.12 mL 0.58 mL 1.17 mL
10 mM 0.06 mL 0.29 mL 0.58 mL
50 mM 0.01 mL 0.06 mL 0.12 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Zweytick et al (2006) Influence of N-acylation of a peptide derived from human lactoferricin on membrane selectivity. Biochim.Biophys.Acta 1758 1426 PMID: 16616888

Rosenfeld et al (2010) Effect of the hydrophobicity to net positive charge ratio on antibacterial and anti-endotoxin activities of structurally similar antimicrobial peptides. Biochemistry 49 853 PMID: 20058937

Andra et al (2005) Enhancement of endotoxin neutralization by coupling of a C12-alkyl chain to a lactoferricin-derived peptide. Biochem.J. 385 135 PMID: 15344905


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Keywords: lauryl-LF11 lps lipopolysaccharide lactoferricin antimicrobial peptides antibiotics Antibiotics

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