Lauryl-LF 11

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Cat.No. 4422 - Lauryl-LF 11 | CH3-(CH2)10-CO-NH-Phe-Gln-Trp-Gln-Arg-Asn-Ile-Arg-Lys-Val-Arg-NH2 | CAS No. 832729-14-3
Description: Analog of LF 11 (Cat. No. 4421); antibiotic
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Citations
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Literature

Biological Activity

N-terminally acylated analog of LF 11 (Cat. No. 4421). Displays enhanced antibacterial and LPS-binding activities.

Technical Data

M. Wt 1712.11
Formula C81H134N26O15
Sequence FQWQRNIRKVR

(Modifications: Phe-1 = CH3-(CH2)10-CO-NH-Phe, Arg-11 = C-terminal amide)

Storage Store at -20°C
CAS Number 832729-14-3
PubChem ID 90488941
InChI Key AUHGQKBFMDAWAQ-BSHYLFJSSA-N
Smiles CCCCCCCCCCCNC(CC1CCCCC1)C(O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)CN[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 2 mg/ml in 30% acetonitrile / water

References

References are publications that support the biological activity of the product.

Zweytick et al (2006) Influence of N-acylation of a peptide derived from human lactoferricin on membrane selectivity. Biochim.Biophys.Acta 1758 1426 PMID: 16616888

Rosenfeld et al (2010) Effect of the hydrophobicity to net positive charge ratio on antibacterial and anti-endotoxin activities of structurally similar antimicrobial peptides. Biochemistry 49 853 PMID: 20058937

Andra et al (2005) Enhancement of endotoxin neutralization by coupling of a C12-alkyl chain to a lactoferricin-derived peptide. Biochem.J. 385 135 PMID: 15344905


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Keywords: Lauryl-LF 11, Lauryl-LF 11 supplier, lauryl-LF11, lps, lipopolysaccharide, lactoferricin, antimicrobial, peptides, antibiotics, Antibiotics, 4422, Tocris Bioscience

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