Leukadherin 1

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Cat.No. 4921 - Leukadherin 1 | C22H15NO4S2 | CAS No. 344897-95-6
Description: Allosteric activator of CD11b/CD18
Chemical Name: 4-[(5-[[4-Oxo-3-(phenylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]-2-furanyl]benzoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (3)

Biological Activity

Allosteric activator of CD11b/CD18. Increases CD11b/CD18-dependent cell adhesion to fibrinogen (EC50 = 4 μM). Decreases leukocyte motility and transendothelial migration; reduces inflammation. Also activates complement receptor 3 (CR3), and promotes CR3-dependent leukocyte adhesion to fibrinogen-coated surfaces.

Technical Data

M. Wt 421.49
Formula C22H15NO4S2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 344897-95-6
PubChem ID 5342077
InChI Key AEZGRQSLKVNPCI-UNOMPAQXSA-N
Smiles S=C(N(CC3=CC=CC=C3)C2=O)S/C2=C\C1=CC=C(C4=CC=C(C(O)=O)C=C4)O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.21 10 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 421.49. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.73 mL 118.63 mL 237.25 mL
0.5 mM 4.75 mL 23.73 mL 47.45 mL
1 mM 2.37 mL 11.86 mL 23.73 mL
5 mM 0.47 mL 2.37 mL 4.75 mL

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References

References are publications that support the biological activity of the product.

Maiguel et al (2011) Small molecule-mediated activation of the integrin CD11b/CD18 reduces inflammatory disease. Sci.Signal. 4 1 PMID: 21900205

Reed et al (2013) Complement receptor 3 influences Toll-like receptor 7/8-dependent inflammation. J.Biol.Chem. 288 9077 PMID: 23386618


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Keywords: Leukadherin 1, Leukadherin 1 supplier, anti-inflammatory, anti-inflammatories, inflammation, leukocyte, extravasation, trans-endothelial, migration, adhesion, CD11b/CD18, activators, allosteric, integrins, Integrins, Cell, Adhesion, Molecules, 4921, Tocris Bioscience

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