Leukadherin 1

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Cat.No. 4921 - Leukadherin 1 | C22H15NO4S2 | CAS No. 344897-95-6
Description: Allosteric activator of CD11b/CD18
Chemical Name: 4-[(5-[[4-Oxo-3-(phenylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]-2-furanyl]benzoic acid
Purity: ≥98% (HPLC)
Literature (3)

Biological Activity for Leukadherin 1

Leukadherin 1 is an allosteric activator of CD11b/CD18. Increases CD11b/CD18-dependent cell adhesion to fibrinogen (EC50 = 4 μM). Decreases leukocyte motility and transendothelial migration; reduces inflammation. Also activates complement receptor 3 (CR3), and promotes CR3-dependent leukocyte adhesion to fibrinogen-coated surfaces.

Technical Data for Leukadherin 1

M. Wt 421.49
Formula C22H15NO4S2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 344897-95-6
PubChem ID 5342077
Smiles S=C(N(CC3=CC=CC=C3)C2=O)S/C2=C\C1=CC=C(C4=CC=C(C(O)=O)C=C4)O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Leukadherin 1

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 4.21 10 with gentle warming

Preparing Stock Solutions for Leukadherin 1

The following data is based on the product molecular weight 421.49. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.73 mL 118.63 mL 237.25 mL
0.5 mM 4.75 mL 23.73 mL 47.45 mL
1 mM 2.37 mL 11.86 mL 23.73 mL
5 mM 0.47 mL 2.37 mL 4.75 mL

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Product Datasheets for Leukadherin 1

References for Leukadherin 1

References are publications that support the biological activity of the product.

Maiguel et al (2011) Small molecule-mediated activation of the integrin CD11b/CD18 reduces inflammatory disease. Sci.Signal. 4 1 PMID: 21900205

Reed et al (2013) Complement receptor 3 influences Toll-like receptor 7/8-dependent inflammation. J.Biol.Chem. 288 9077 PMID: 23386618

If you know of a relevant reference for Leukadherin 1, please let us know.

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Keywords: Leukadherin 1, Leukadherin 1 supplier, anti-inflammatory, anti-inflammatories, inflammation, leukocyte, extravasation, trans-endothelial, migration, adhesion, CD11b/CD18, activators, allosteric, integrins, Integrins, Cell, Adhesion, Molecules, 4921, Tocris Bioscience

Citations for Leukadherin 1

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