LEI 401

Pricing Availability   Qty
Description: High affinity N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) inhibitor
Chemical Name: N-(Cyclopropylmethyl)-6-[(3S)-3-hydroxy-1-pyrrolidinyl]-2-[(3S)-3-phenyl-1-piperidinyl]-4-pyrimidinecarboxamide
Purity: ≥98% (HPLC)

Biological Activity for LEI 401

LEI 401 is a high affinity N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) inhibitor (Ki = 0.027 and 0.18 μM for human and mouse NAPE-PLD, respectively; IC50 for human enzyme = 0.86 μM). LEI 401 exhibits no significant activity at cannabinoid receptors or other metabolic enzymes of the endocannabinoid system. The product reduces levels of N-acylethanolamines (NAE) in a neuroblastoma cell line in vitro. It also reduces anandamide levels in mouse brain in vivo and impairs fear extinction. LEI 701 is CNS penetrant and cell-permeable.

Licensing Information

Sold with kind permission of Professor van der Stelt

Compound Libraries for LEI 401

LEI 401 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for LEI 401

M. Wt 421.55
Formula C24H31N5O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2393840-15-6
PubChem ID 145998143
Smiles O[C@H]1CCN(C2=NC(N3CCC[C@@H](C4=CC=CC=C4)C3)=NC(C(NCC5CC5)=O)=C2)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for LEI 401

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 42.16 100
ethanol 21.1 50

Preparing Stock Solutions for LEI 401

The following data is based on the product molecular weight 421.55. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.37 mL 11.86 mL 23.72 mL
5 mM 0.47 mL 2.37 mL 4.74 mL
10 mM 0.24 mL 1.19 mL 2.37 mL
50 mM 0.05 mL 0.24 mL 0.47 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

References for LEI 401

References are publications that support the biological activity of the product.

Mock et al (2020) Discovery of a NAPE-PLD inhibitor that modulates emotional behavior in mice. Nat.Chem.Biol. 16 667 PMID: 32393901

If you know of a relevant reference for LEI 401, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Phospholipase Inhibitors

Keywords: LEI 401, LEI 401 supplier, LEI401, N-acylphosphatidylethanolamine, phospholipase, D, NAPEPLD, N-acylethanolamines, NAE, inhibitors, inhibits, high, affinity, brain, penetrant, cell, permeable, endocannabinoids, cannabinoids, Phospholipases, 7407, Tocris Bioscience

Citations for LEI 401

Citations are publications that use Tocris products.

Currently there are no citations for LEI 401. Do you know of a great paper that uses LEI 401 from Tocris? Please let us know.

Reviews for LEI 401

There are currently no reviews for this product. Be the first to review LEI 401 and earn rewards!

Have you used LEI 401?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review