LDN 212854

Pricing Availability Delivery Time Qty
Cat.No. 6151 - LDN 212854 | C25H22N6 | CAS No. 1432597-26-6
Description: Potent bone morphogenetic protein type I (ALK) inhibitor
Chemical Name: 5-(6-(4-(1-Piperazinyl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature
Pathways

Biological Activity

Potent ALK inhibitor (IC50 values are 1.3, 2.4, 85.8, 2,133 and 9,276 nM for ALK2, ALK1, ALK3, ALK4 and ALK5, respectively). Exhibits selectivity for ALK2 over ALK4 and ALK5 in cellular assays. Inhibits heterotopic ossification in a mutant ALK2 mouse model of fibrodysplasia ossificans progressiva. Also exhibits activity against RIPK2, ABL1 and PDGFR-β (IC50 values < 100 nM).

Licensing Information

Sold for research purposes under exclusive agreement from The Brigham and Women's Hospital Inc. US patent 14/776,302

Technical Data

M. Wt 406.48
Formula C25H22N6
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1432597-26-6
PubChem ID 60182388
InChI Key BBDGBGOVJPEFBT-UHFFFAOYSA-N
Smiles N1(C2=CC=C(C3=CN4N=CC(C5=CC=CC6=C5C=CC=N6)=C4N=C3)C=C2)CCNCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 1.02 2.5mM with gentle warming
2eq.HCl 20.32 50

Preparing Stock Solutions

The following data is based on the product molecular weight 406.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.46 mL 12.3 mL 24.6 mL
5 mM 0.49 mL 2.46 mL 4.92 mL
10 mM 0.25 mL 1.23 mL 2.46 mL
50 mM 0.05 mL 0.25 mL 0.49 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Mohedas et al (2013) Development of an ALK2-biased BMP type I receptor kinase inhibitor. ACS Chem.Biol. 8 1291 PMID: 23547776


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View Related Products by Product Action

View all BMP and Other Activin Receptor Inhibitors

Keywords: LDN212854 ALK inhibitors inhibits potent in vivo active BMP1 ALK2 bone morphogenetic protein type I BMP and Other Activin Receptors

Citations for LDN 212854

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases

Pathways for LDN 212854

TGF-β

TGF-β Signaling Pathway

The TGF-β signaling pathway is involved in the regulation of growth and proliferation of cells along with migration, differentiation and apoptosis.

Protocols

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