LC 2 Epimer

Pricing Availability   Qty
Description: Negative control for LC 2 (Cat. No. 7420)
Chemical Name: (2S,4S)-1-((S)-2-(3-(3-((S)-2-(((7-(8-Chloronaphthalen-1-yl)-4-((S)-3-(cyanomethyl)-4-(2-fluoroacryloyl)piperazin-1-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)oxy)methyl)pyrrolidin-1-yl)propoxy)propanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity: ≥95% (HPLC)
Literature (2)

Biological Activity for LC 2 Epimer

Negative control for LC 2 (Cat. No. 7420).

Technical Data for LC 2 Epimer

M. Wt 1132.8
Formula C59H71ClFN11O7S
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 2502156-12-7
Smiles CC1=C(SC=N1)C2=CC=C(CNC([C@@H]3C[C@H](O)CN3C([C@@H](NC(CCOCCCN4CCC[C@H]4COC5=NC(N6CCN([C@@H](CC#N)C6)C(C(F)=C)=O)=C7CCN(CC7=N5)C8=CC=CC9=C8C(Cl)=CC=C9)=O)C(C)(C)C)=O)=O)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for LC 2 Epimer

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 113.28 100

Preparing Stock Solutions for LC 2 Epimer

The following data is based on the product molecular weight 1132.8. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.88 mL 4.41 mL 8.83 mL
5 mM 0.18 mL 0.88 mL 1.77 mL
10 mM 0.09 mL 0.44 mL 0.88 mL
50 mM 0.02 mL 0.09 mL 0.18 mL

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References for LC 2 Epimer

References are publications that support the biological activity of the product.

De Vita et al (2020) The missing link between (un)druggable and degradable KRAS. ACS Cent.Sci. 6 1281 PMID: 32875070

Bond et al (2020) Targeted degradation of oncogenic KRAS G12C by VHL-recruiting PROTACs. ACS Cent.Sci. 6 1367 PMID: 32875077

If you know of a relevant reference for LC 2 Epimer, please let us know.

Keywords: LC 2 Epimer, LC 2 Epimer supplier, LC2, PROTACs, negative, controls, degraders, degrades, KRAS, inhibitor, inhibition, Ras, GTPases, Negative, Controls, 7421, Tocris Bioscience

Citations for LC 2 Epimer

Citations are publications that use Tocris products.

Currently there are no citations for LC 2 Epimer. Do you know of a great paper that uses LC 2 Epimer from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Targeted Protein Degradation Research Product Guide

Targeted Protein Degradation Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support Targeted Protein Degradation research, including:

  • Active Degraders
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  • Degrader Building Blocks
  • Ubiquitin-Proteasome System Proteins
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Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia