Lamotrigine isethionate

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Cat.No. 2289 - Lamotrigine isethionate | C9H7Cl2N5.C2H6O4S | CAS No. 113170-86-8
Description: Inhibits glutamate release. Water-soluble salt of lamotrigine (Cat. No. 1611)
Chemical Name: 6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine isethionate
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Water-soluble salt of lamotrigine (Cat. No. 1611). Displays anticonvulsant effects and inhibits glutamate release, possibly through inhibition of Na+, K+ and Ca2+ currents.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Technical Data

M. Wt 382.22
Formula C9H7Cl2N5.C2H6O4S
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 113170-86-8
PubChem ID 45039646
InChI Key CJIDZLNMKONKAD-UHFFFAOYSA-N
Smiles OCCS(O)(=O)=O.NC1=NC(N)=C(N=N1)C1=CC=CC(Cl)=C1Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 38.22 100
water 38.22 100mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 382.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.62 mL 13.08 mL 26.16 mL
5 mM 0.52 mL 2.62 mL 5.23 mL
10 mM 0.26 mL 1.31 mL 2.62 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Leach et al (1991) Neurochemical and behavioral aspects of lamotrigine. Epilepsia 32 S4 PMID: 1685439

Smith and Meldrum (1995) Cardioprotective effect of lamotrigine after focal ischemia in rats. Stroke 26 117 PMID: 7839380

Zona and Avoli (1997) Lamotrigine reduces voltage-gated sodium currents in rat central neurons in culture. Epilepsia 38 522 PMID: 9184596

Grunze et al (1998) Modulation of calcium and potassium currents by lamotrigine. Neuropsychobiology 38 131 PMID: 9778600


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Keywords: Lamotrigine isethionate, supplier, inhibitors, inhibits, glutamate, release, Receptors, GlaxoSmithKline, GSK, Miscellaneous, Glutamate, Other, Channel, Modulators, Miscellaneous, Glutamate, Tocris Bioscience

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