Water-soluble salt of lamotrigine (Cat. No. 1611). Displays anticonvulsant effects and inhibits glutamate release, possibly through inhibition of Na+, K+ and Ca2+ currents.
Sold for research purposes under agreement from GlaxoSmithKline
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|water||38.22||100mM with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 382.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.62 mL||13.08 mL||26.16 mL|
|5 mM||0.52 mL||2.62 mL||5.23 mL|
|10 mM||0.26 mL||1.31 mL||2.62 mL|
|50 mM||0.05 mL||0.26 mL||0.52 mL|
References are publications that support the products' biological activity.
Leach et al (1991) Neurochemical and behavioral aspects of lamotrigine. Epilepsia 32 S4 PMID: 1685439
Smith and Meldrum (1995) Cardioprotective effect of lamotrigine after focal ischemia in rats. Stroke 26 117 PMID: 7839380
Zona and Avoli (1997) Lamotrigine reduces voltage-gated sodium currents in rat central neurons in culture. Epilepsia 38 522 PMID: 9184596
Grunze et al (1998) Modulation of calcium and potassium currents by lamotrigine. Neuropsychobiology 38 131 PMID: 9778600
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Keywords: Lamotrigine isethionate, supplier, inhibitors, inhibits, glutamate, release, Receptors, GlaxoSmithKline, GSK, Miscellaneous, Glutamate, Other, Channel, Modulators, Miscellaneous, Glutamate, Tocris Bioscience
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