Lamotrigine isethionate

Pricing Availability   Qty
Description: Inhibits glutamate release. Water-soluble salt of lamotrigine (Cat. No. 1611)
Chemical Name: 6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine isethionate
Purity: ≥99% (HPLC)
Citations (1)
Literature (3)

Biological Activity for Lamotrigine isethionate

Lamotrigine isethionate is a water-soluble salt of lamotrigine (Cat. No. 1611). Displays anticonvulsant effects and inhibits glutamate release, possibly through inhibition of Na+, K+ and Ca2+ currents.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Technical Data for Lamotrigine isethionate

M. Wt 382.22
Formula C9H7Cl2N5.C2H6O4S
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 113170-86-8
PubChem ID 45039646
Smiles OCCS(O)(=O)=O.NC1=NC(N)=C(N=N1)C1=CC=CC(Cl)=C1Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Lamotrigine isethionate

Solvent Max Conc. mg/mL Max Conc. mM
water 38.22 100 with gentle warming

Preparing Stock Solutions for Lamotrigine isethionate

The following data is based on the product molecular weight 382.22. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.62 mL 13.08 mL 26.16 mL
5 mM 0.52 mL 2.62 mL 5.23 mL
10 mM 0.26 mL 1.31 mL 2.62 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for Lamotrigine isethionate

Certificate of Analysis / Product Datasheet
Select another batch:

References for Lamotrigine isethionate

References are publications that support the biological activity of the product.

Leach et al (1991) Neurochemical and behavioral aspects of lamotr. Epilepsia 32 S4 PMID: 1685439

Smith and Meldrum (1995) Cardioprotective effect of lamotr. after focal ischemia in rats. Stroke 26 117 PMID: 7839380

Zona and Avoli (1997) Lamotrigine reduces voltage-gated sodium currents in rat central neurons in culture. Epilepsia 38 522 PMID: 9184596

Grunze et al (1998) Modulation of calcium and potassium currents by lamotr. Neuropsychobiology 38 131 PMID: 9778600

If you know of a relevant reference for Lamotrigine isethionate, please let us know.

Keywords: Lamotrigine isethionate, Lamotrigine isethionate supplier, inhibitors, inhibits, glutamate, release, Receptors, GlaxoSmithKline, GSK, Miscellaneous, Glutamate, Other, Channel, Modulators, 2289, Tocris Bioscience

1 Citation for Lamotrigine isethionate

Citations are publications that use Tocris products. Selected citations for Lamotrigine isethionate include:

Madry et al (2018) Microglial Ramification, Surveillance, and Interleukin-1β Release Are Regulated by the Two-Pore Domain K+ Channel THIK-1. Neuron 97 299 PMID: 29290552

Do you know of a great paper that uses Lamotrigine isethionate from Tocris? Please let us know.

Reviews for Lamotrigine isethionate

There are currently no reviews for this product. Be the first to review Lamotrigine isethionate and earn rewards!

Have you used Lamotrigine isethionate?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Metabotropic Glutamate Receptors Scientific Review

Metabotropic Glutamate Receptors Scientific Review

Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.

Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.