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L189

Cat. No. 3561 Submit a Review Datasheet / COA / SDS
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Description: DNA ligase I, III and IV inhibitor
Chemical Name: 6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for L189

L189 is a DNA ligase I, III and IV inhibitor (IC50 values are 5, 9 and 5 μM respectively) that blocks DNA binding (Ki = 5 μM for DNA ligase I). Preferentially inhibits step 2 of the ligation reaction, and inhibits base excision repair (BER) and non-homologous end joining (NHEJ). Specifically sensitizes cancer cells to DNA damage and increases the cytotoxicity of DNA-damaging agents.

Technical Data for L189

M. Wt 246.29
Formula C11H10N4OS
Storage Store at -20°C
CAS Number 64232-83-3
PubChem ID 824710
InChI Key SAKOXVNKDMWWLF-UHFFFAOYSA-N
Smiles S=C1NC(N)=C(/N=C/C2=CC=CC=C2)C(N1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for L189

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 24.63 100

Preparing Stock Solutions for L189

The following data is based on the product molecular weight 246.29. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.06 mL 20.3 mL 40.6 mL
5 mM 0.81 mL 4.06 mL 8.12 mL
10 mM 0.41 mL 2.03 mL 4.06 mL
50 mM 0.08 mL 0.41 mL 0.81 mL

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Product Datasheets for L189

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for L189

References are publications that support the biological activity of the product.

Chen et al (2008) Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair. Cancer Res. 68 3169 PMID: 18451142

If you know of a relevant reference for L189, please let us know.

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Keywords: L189, L189 supplier, DNA, ligases, I, III, IV, 1, 3, 4, inhibitors, inhibits, Ligases, 3561, Tocris Bioscience

Citations for L189

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