DNA ligase I, III and IV inhibitor (IC50 values are 5, 9 and 5 μM respectively) that blocks DNA binding (Ki = 5 μM for DNA ligase I). Preferentially inhibits step 2 of the ligation reaction, and inhibits base excision repair (BER) and non-homologous end joining (NHEJ). Specifically sensitizes cancer cells to DNA damage and increases the cytotoxicity of DNA-damaging agents.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 246.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.06 mL||20.3 mL||40.6 mL|
|5 mM||0.81 mL||4.06 mL||8.12 mL|
|10 mM||0.41 mL||2.03 mL||4.06 mL|
|50 mM||0.08 mL||0.41 mL||0.81 mL|
References are publications that support the biological activity of the product.
Chen et al (2008) Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair. Cancer Res. 68 3169 PMID: 18451142
If you know of a relevant reference for L189, please let us know.
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Keywords: L189, L189 supplier, DNA, ligases, I, III, IV, 1, 3, 4, inhibitors, inhibits, Ligases, 3561, Tocris Bioscience
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