L189

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Cat.No. 3561 - L189 | C11H10N4OS | CAS No. 64232-83-3
Description: DNA ligase I, III and IV inhibitor
Chemical Name: 6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone
Datasheet
Citations
Literature

Biological Activity

DNA ligase I, III and IV inhibitor (IC50 values are 5, 9 and 5 μM respectively) that blocks DNA binding (Ki = 5 μM for DNA ligase I). Preferentially inhibits step 2 of the ligation reaction, and inhibits base excision repair (BER) and non-homologous end joining (NHEJ). Specifically sensitizes cancer cells to DNA damage and increases the cytotoxicity of DNA-damaging agents.

Technical Data

M. Wt 246.29
Formula C11H10N4OS
Storage Store at -20°C
CAS Number 64232-83-3
PubChem ID 824710
InChI Key SAKOXVNKDMWWLF-UHFFFAOYSA-N
Smiles S=C1NC(N)=C(/N=C/C2=CC=CC=C2)C(N1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 24.63 100

Preparing Stock Solutions

The following data is based on the product molecular weight 246.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.06 mL 20.3 mL 40.6 mL
5 mM 0.81 mL 4.06 mL 8.12 mL
10 mM 0.41 mL 2.03 mL 4.06 mL
50 mM 0.08 mL 0.41 mL 0.81 mL

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References

References are publications that support the products' biological activity.

Chen et al (2008) Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair. Cancer Res. 68 3169 PMID: 18451142


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Keywords: L189, supplier, DNA, ligases, I, III, IV, 1, 3, 4, inhibitors, inhibits, DNA, Ligases, DNA, Ligases, Tocris Bioscience

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