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Submit ReviewL-Serine
Description: Weak endogenous glycine receptor agonist
Chemical Name: β-Hydroxyalanine
Purity: ≥99% (HPLC)
Technical Data
| M. Wt | 105.09 |
| Formula | C3H7NO3 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 56-45-1 |
| PubChem ID | 5951 |
| InChI Key | MTCFGRXMJLQNBG-REOHCLBHSA-N |
| Smiles | OC[C@]([H])(N)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 105.09. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 9.52 mL | 47.58 mL | 95.16 mL |
| 5 mM | 1.9 mL | 9.52 mL | 19.03 mL |
| 10 mM | 0.95 mL | 4.76 mL | 9.52 mL |
| 50 mM | 0.19 mL | 0.95 mL | 1.9 mL |
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References
References are publications that support the biological activity of the product.
Saitoh et al (1994) A novel antagonist, phenylbenzene ω-phosphono-α-amino acid, for strychnine-sensitive glycine receptors in the rat spinal cord. Br.J.Pharmacol. 113 165 PMID: 7812607
Schmeiden and Betz (1995) Pharmacology of the inhibitory glycine receptor: agonist and antagonist actions of amino acids and piperidine carboxylic acid compounds. Mol.Pharmacol. 48 919 PMID: 7476923
If you know of a relevant reference for L-Serine, please let us know.
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Keywords: L-Serine, L-Serine supplier, endogenous, glycine, receptor, agonists, GlyR, Glycine, Receptors, beta-Hydroxyalanine, b-Hydroxyalanine, β-Hydroxyalanine, Amino, Acids, 0227, Tocris Bioscience
1 Citation for L-Serine
Citations are publications that use Tocris products. Selected citations for L-Serine include:
Potier et al (2010) Contribution of the d-Serine-Dependent Pathway to the Cellular Mechanisms Underlying Cognitive Aging. Front Aging Neurosci 2 1 PMID: 20552041
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