Glycine agonist at the NMDA receptor. L-Serine (Cat. No. 0227) also available.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 100 mM in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 105.09. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||9.52 mL||47.58 mL||95.16 mL|
|5 mM||1.9 mL||9.52 mL||19.03 mL|
|10 mM||0.95 mL||4.76 mL||9.52 mL|
|50 mM||0.19 mL||0.95 mL||1.9 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
If you know of a relevant reference for D-Serine, please let us know.
Keywords: Potentiator glycine site Glutamate NMDA Receptors N-Methyl-D-Aspartate iGluR Ionotropic NMDA Receptors
6 Citations for D-Serine
Citations are publications that use Tocris products. Selected citations for D-Serine include:
Lee et al (2012) Lovastatin modulates glycogen synthase kinase-3β pathway and inhibits mossy fiber sprouting after pilocarpine-induced status epilepticus. J Biol Chem 7 e38789 PMID: 22761705
Potier et al (2010) Contribution of the d-Serine-Dependent Pathway to the Cellular Mechanisms Underlying Cognitive Aging. Front Aging Neurosci 2 1 PMID: 20552041
Inoue et al (2008) NMDA- and β-amyloid1-42-induced neurotoxicity is attenuated in serine racemase knock-out mice. PLoS One 28 14486 PMID: 19118183
Morante-Oria et al (2003) Subpallial origin of a population of projecting pioneer neurons during corticogenesis. Proc Natl Acad Sci U S A 100 12468 PMID: 14523241
Laprell et al (2015) Optical control of NMDA receptors with a diffusible photoswitch. Proc Natl Acad Sci U S A 6 8076 PMID: 26311290
Shin et al (2015) Muscarinic regulation of dopamine and glutamate transmission in the nucleus accumbens. J Neurosci 112 8124 PMID: 26080439
Do you know of a great paper that uses D-Serine from Tocris? If so please let us know.
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