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Submit ReviewD-Serine
Description: Potentiator of NMDA recepors; acts at glycine site
Biological Activity for D-Serine
D-Serine is a glycine agonist at the NMDA receptor.
L-isomer also available.
Technical Data for D-Serine
| M. Wt | 105.09 |
| Formula | C3H7NO3 |
| Storage | Store at RT |
| CAS Number | 312-84-5 |
| PubChem ID | 71077 |
| InChI Key | MTCFGRXMJLQNBG-UWTATZPHSA-N |
| Smiles | N[C@@]([H])([C@](O)=O)CO |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for D-Serine
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 100 |
Preparing Stock Solutions for D-Serine
The following data is based on the product molecular weight 105.09. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 9.52 mL | 47.58 mL | 95.16 mL |
| 5 mM | 1.9 mL | 9.52 mL | 19.03 mL |
| 10 mM | 0.95 mL | 4.76 mL | 9.52 mL |
| 50 mM | 0.19 mL | 0.95 mL | 1.9 mL |
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Product Datasheets for D-Serine
References for D-Serine
References are publications that support the biological activity of the product.
Schell et al (1997) D-Serine as a neuromodulator: regional and developmental localizations in rat brain glia resemble NMDA receptors. J. Neurosci. 17 1604 PMID: 9030620
Lodge (1989) Non-competitive NMDA antagonists. The NMDA Receptor (2nd edition). Eds. G.L.Collingr 37
Mothet et al (2000) D-serine is an endogenous ligand for the glycine site of the N-methyl-D-aspartate receptor. Proc.Natl.Acad.Sci.USA 97 4926 PMID: 10781100
If you know of a relevant reference for D-Serine, please let us know.
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Keywords: D-Serine, D-Serine supplier, Potentiator, glycine, site, Glutamate, NMDA, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, Amino, Acids, 0226, Tocris Bioscience
8 Citations for D-Serine
Citations are publications that use Tocris products. Selected citations for D-Serine include:
Romanos et al (2019) Differences in glutamate uptake between cortical regions impact neuronal NMDA receptor activation. Commun Biol 2 127 PMID: 30963115
Lee et al (2012) Lovastatin modulates glycogen synthase kinase-3β pathway and inhibits mossy fiber sprouting after PilC-induced status epilepticus. J Biol Chem 7 e38789 PMID: 22761705
Potier et al (2010) Contribution of the d-Serine-Dependent Pathway to the Cellular Mechanisms Underlying Cognitive Aging. Front Aging Neurosci 2 1 PMID: 20552041
Laprell et al (2015) Optical control of NMDA receptors with a diffusible photoswitch. Proc Natl Acad Sci U S A 6 8076 PMID: 26311290
Shin et al (2015) Muscarinic regulation of DA and glutamate transmission in the nucleus accumbens. J Neurosci 112 8124 PMID: 26080439
Morante-Oria et al (2003) Subpallial origin of a population of projecting pioneer neurons during corticogenesis. Proc Natl Acad Sci U S A 100 12468 PMID: 14523241
Inoue et al (2008) NMDA- and β-amyloid1-42-induced neurotoxicity is attenuated in serine racemase knock-out mice. PLoS One 28 14486 PMID: 19118183
Adamsky et al (2018) Astrocytic Activation Generates De Novo Neuronal Potentiation and Memory Enhancement. Cell 174 59 PMID: 29804835
Do you know of a great paper that uses D-Serine from Tocris? Please let us know.
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