Vanilloid TRPV1 (VR1) receptor antagonist peptide (IC50 ~ 0.1 μM); blocks Ca2+ currents in dorsal root ganglion neurons. Analgesic in vivo.
(Modifications: Trp-6 = C-terminal amide)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 1 mg/ml in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 1014.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.99 mL||4.93 mL||9.86 mL|
|5 mM||0.2 mL||0.99 mL||1.97 mL|
|10 mM||0.1 mL||0.49 mL||0.99 mL|
|50 mM||0.02 mL||0.1 mL||0.2 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Himmel et al (2002) The arginine-rich hexapeptide R4W2 is a stereoselective antagonist at the vanilloid receptor 1: a Ca2+ imaging study in adult rat dorsal root ganglion neurons. J.Pharmacol.Exp.Ther. 301 981 PMID: 12023528
Planells-Cases et al (2000) Arginine-rich peptides are blockers of VR-1 channels with analgesic activity. FEBS Lett. 481 131 PMID: 10996311
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Keywords: TRPV1 antagonists peptide Vanillioid Receptors VR1 TRPV Channels Transient Receptor Potential TRPV
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Literature in this Area
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