L-R4W2

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Cat.No. 1577 - L-R4W2 | Arg-Arg-Arg-Arg-Trp-Trp-NH2 | CAS No. 206350-79-0
Description: TRPV1 antagonist peptide
Datasheet
Citations
Reviews
Literature

Biological Activity

Vanilloid TRPV1 (VR1) receptor antagonist peptide (IC50 ~ 0.1 μM); blocks Ca2+ currents in dorsal root ganglion neurons. Analgesic in vivo.

Technical Data

M. Wt 1014.2
Formula C46H71N21O6
Sequence RRRRWW

(Modifications: Trp-6 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 206350-79-0
PubChem ID 90479804
InChI Key MGQHBRDQUJRCLN-UJARKJSPSA-N
Smiles [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 1 mg/ml in water

References

References are publications that support the biological activity of the product.

Himmel et al (2002) The arginine-rich hexapeptide R4W2 is a stereoselective antagonist at the vanilloid receptor 1: a Ca2+ imaging study in adult rat dorsal root ganglion neurons. J.Pharmacol.Exp.Ther. 301 981 PMID: 12023528

Planells-Cases et al (2000) Arginine-rich peptides are blockers of VR-1 channels with analgesic activity. FEBS Lett. 481 131 PMID: 10996311


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Keywords: L-R4W2, L-R4W2 supplier, TRPV1, antagonists, peptide, Vanillioid, Receptors, VR1, TRPV, Channels, Transient, Receptor, Potential, 1577, Tocris Bioscience

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Literature in this Area

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