L-ODAP sodium salt
Discontinued ProductUnfortunately L-ODAP sodium salt (Cat. No. 0200) has been withdrawn from sale for commercial reasons.
Potent agonist, active at non-NMDA receptors. Excitotoxin, possibly involved in the aetiology of human lathyrism.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Preparing Stock Solutions
The following data is based on the product molecular weight 198.11. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||5.05 mL||25.24 mL||50.48 mL|
|5 mM||1.01 mL||5.05 mL||10.1 mL|
|10 mM||0.5 mL||2.52 mL||5.05 mL|
|50 mM||0.1 mL||0.5 mL||1.01 mL|
References are publications that support the products' biological activity.
Baron et al (1990) Activity of 5,7-dichlorokynurenic acid. A potent antagonist at the NMDA receptor-associated glycine binding site. Mol.Pharmacol. 38 554 PMID: 2172769
Bridges et al (1988) Inhibition of [3H]-AMPA binding by the excitotoxin β-N-oxalyl-L-α,β-diaminopropionic acid. Eur.J. Pharmacol. 145 357 PMID: 2895006
Ludolph et al (1987) Studies on the aetiology and pathogenesis of motor neurone diseases. Brain 110 149 PMID: 3801847
Spencer et al (1987) Guam amyotrophic lateral sclerosis - Parkinsonism - dementia linked to a plant excitant neurotoxin. Science 237 517 PMID: 3603037
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Keywords: L-ODAP sodium salt, supplier, L-BOAA, b-Oxalylamino-L-alanine, AMPA, Receptors, AMPA, Receptors, Tocris Bioscience
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Literature in this Area
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The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
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Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Learning & Memory Poster
Recognition memory enables us to make judgements about whether or not we have encountered a particular stimulus before. This poster outlines the cellular mechanisms underlying recognition memory and its links to long-term depression, as well as the use of pharmacological intervention to assess the role of neurotransmitters in recognition memory.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.
Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.