L-NIL hydrochloride

Pricing Availability   Qty
Description: Selective iNOS inhibitor
Chemical Name: N6-(1-Iminoethyl)-L-lysine hydrochloride
Citations (4)
Literature (1)

Biological Activity for L-NIL hydrochloride

L-NIL hydrochloride is a selective inhibitor of inducible nitric oxide synthase (IC50 = 3.3 μM).

Technical Data for L-NIL hydrochloride

M. Wt 223.7
Formula C8H17N3O2.HCl
Storage Desiccate at -20°C
CAS Number 150403-89-7
PubChem ID 9794509
Smiles N=C(NCCCC[C@@H](C(O)=O)N)C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for L-NIL hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 22.37 100

Preparing Stock Solutions for L-NIL hydrochloride

The following data is based on the product molecular weight 223.7. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.47 mL 22.35 mL 44.7 mL
5 mM 0.89 mL 4.47 mL 8.94 mL
10 mM 0.45 mL 2.24 mL 4.47 mL
50 mM 0.09 mL 0.45 mL 0.89 mL

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Product Datasheets for L-NIL hydrochloride

Certificate of Analysis / Product Datasheet
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References for L-NIL hydrochloride

References are publications that support the biological activity of the product.

Connor et al (1995) Suppression of adjuvant-induced arthritis by selective inhibition of inducible nitric oxide synthase. Eur.J.Pharmacol. 273 15 PMID: 7537678

Moore et al (1994) L-N6-(1-Iminoethyl)lysine: a selective inhibitor of inducible nitric oxide synthase. J.Med.Chem. 37 3886 PMID: 7525961

If you know of a relevant reference for L-NIL hydrochloride, please let us know.

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Keywords: L-NIL hydrochloride, L-NIL hydrochloride supplier, Selective, iNOS, inhibitors, inhibits, Nitric, Oxide, Signaling, Signalling, Inducible, NO, Synthases, 1139, Tocris Bioscience

4 Citations for L-NIL hydrochloride

Citations are publications that use Tocris products. Selected citations for L-NIL hydrochloride include:

Elks et al (2013) Hypoxia inducible factor signaling modulates susceptibility to mycobacterial infection via a nitric oxide dependent mechanism. PLoS Pathog 9 e1003789 PMID: 24367256

Hervera et al (2011) Peripheral effects of mor. and expression of μ-opioid receptors in the dorsal root ganglia during neuropathic pain: nitric oxide signaling. Mol Pain 7 25 PMID: 21486477

Pais et al (2008) Necrotic neurons enhance microglial neurotoxicity through induction of glutaminase by a MyD88-dependent pathway. Mar Drugs 5 43 PMID: 18844999

Hervera et al (2010) The role of nitric oxide in the local antiallodynic and antihyperalgesic effects and expression of delta-opioid and cannabinoid-2 receptors during neuropathic pain in mice. J Pharmacol Exp Ther 334 887 PMID: 20498253

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Literature in this Area

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