A selective inhibitor of inducible nitric oxide synthase (IC50 = 3.3 μM).
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 100 mM in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 223.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.47 mL||22.35 mL||44.7 mL|
|5 mM||0.89 mL||4.47 mL||8.94 mL|
|10 mM||0.45 mL||2.24 mL||4.47 mL|
|50 mM||0.09 mL||0.45 mL||0.89 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Connor et al (1995) Suppression of adjuvant-induced arthritis by selective inhibition of inducible nitric oxide synthase. Eur.J.Pharmacol. 273 15 PMID: 7537678
Moore et al (1994) L-N6-(1-Iminoethyl)lysine: a selective inhibitor of inducible nitric oxide synthase. J.Med.Chem. 37 3886 PMID: 7525961
If you know of a relevant reference for L-NIL hydrochloride, please let us know.
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Keywords: L-NIL hydrochloride, supplier, Selective, iNOS, inhibitors, inhibits, Nitric, Oxide, Signaling, Signalling, Inducible, NO, Synthases, iNOS, Tocris Bioscience
2 Citations for L-NIL hydrochloride
Citations are publications that use Tocris products. Selected citations for L-NIL hydrochloride include:
Elks et al (2013) Hypoxia inducible factor signaling modulates susceptibility to mycobacterial infection via a nitric oxide dependent mechanism. PLoS Pathog 9 e1003789 PMID: 24367256
Pais et al (2008) Necrotic neurons enhance microglial neurotoxicity through induction of glutaminase by a MyD88-dependent pathway. Mar Drugs 5 43 PMID: 18844999
Do you know of a great paper that uses L-NIL hydrochloride from Tocris? If so please let us know.