L-NIL hydrochloride

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Cat.No. 1139 - L-NIL hydrochloride | C8H17N3O2.HCl | CAS No. 150403-89-7
Description: Selective iNOS inhibitor
Chemical Name: N6-(1-Iminoethyl)-L-lysine hydrochloride
Datasheet
Citations (2)
Literature

Biological Activity

A selective inhibitor of inducible nitric oxide synthase (IC50 = 3.3 μM).

Technical Data

M. Wt 223.7
Formula C8H17N3O2.HCl
Storage Desiccate at -20°C
CAS Number 150403-89-7
PubChem ID 9794509
InChI Key HJYWSATZDBEAOS-FJXQXJEOSA-N
Smiles N=C(NCCCC[C@@H](C(O)=O)N)C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in water

Preparing Stock Solutions

The following data is based on the product molecular weight 223.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.47 mL 22.35 mL 44.7 mL
5 mM 0.89 mL 4.47 mL 8.94 mL
10 mM 0.45 mL 2.24 mL 4.47 mL
50 mM 0.09 mL 0.45 mL 0.89 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Connor et al (1995) Suppression of adjuvant-induced arthritis by selective inhibition of inducible nitric oxide synthase. Eur.J.Pharmacol. 273 15 PMID: 7537678

Moore et al (1994) L-N6-(1-Iminoethyl)lysine: a selective inhibitor of inducible nitric oxide synthase. J.Med.Chem. 37 3886 PMID: 7525961


If you know of a relevant reference for L-NIL hydrochloride, please let us know.

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Keywords: L-NIL hydrochloride, supplier, Selective, iNOS, inhibitors, inhibits, Nitric, Oxide, Signaling, Signalling, Inducible, NO, Synthases, iNOS, Tocris Bioscience

2 Citations for L-NIL hydrochloride

Citations are publications that use Tocris products. Selected citations for L-NIL hydrochloride include:

Elks et al (2013) Hypoxia inducible factor signaling modulates susceptibility to mycobacterial infection via a nitric oxide dependent mechanism. PLoS Pathog 9 e1003789 PMID: 24367256

Pais et al (2008) Necrotic neurons enhance microglial neurotoxicity through induction of glutaminase by a MyD88-dependent pathway. Mar Drugs 5 43 PMID: 18844999


Do you know of a great paper that uses L-NIL hydrochloride from Tocris? If so please let us know.

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