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Biological Activity for L-NIL hydrochloride
L-NIL hydrochloride is a selective inhibitor of inducible nitric oxide synthase (IC50 = 3.3 μM).
Technical Data for L-NIL hydrochloride
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for L-NIL hydrochloride
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for L-NIL hydrochloride
The following data is based on the product molecular weight 223.7. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.47 mL||22.35 mL||44.7 mL|
|5 mM||0.89 mL||4.47 mL||8.94 mL|
|10 mM||0.45 mL||2.24 mL||4.47 mL|
|50 mM||0.09 mL||0.45 mL||0.89 mL|
Product Datasheets for L-NIL hydrochloride
References for L-NIL hydrochloride
References are publications that support the biological activity of the product.
Connor et al (1995) Suppression of adjuvant-induced arthritis by selective inhibition of inducible nitric oxide synthase. Eur.J.Pharmacol. 273 15 PMID: 7537678
Moore et al (1994) L-N6-(1-Iminoethyl)lysine: a selective inhibitor of inducible nitric oxide synthase. J.Med.Chem. 37 3886 PMID: 7525961
If you know of a relevant reference for L-NIL hydrochloride, please let us know.
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Keywords: L-NIL hydrochloride, L-NIL hydrochloride supplier, Selective, iNOS, inhibitors, inhibits, Nitric, Oxide, Signaling, Signalling, Inducible, NO, Synthases, 1139, Tocris Bioscience
4 Citations for L-NIL hydrochloride
Citations are publications that use Tocris products. Selected citations for L-NIL hydrochloride include:
Pais et al (2008) Necrotic neurons enhance microglial neurotoxicity through induction of glutaminase by a MyD88-dependent pathway. Mar Drugs 5 43 PMID: 18844999
Hervera et al (2010) The role of nitric oxide in the local antiallodynic and antihyperalgesic effects and expression of delta-opioid and cannabinoid-2 receptors during neuropathic pain in mice. J Pharmacol Exp Ther 334 887 PMID: 20498253
Elks et al (2013) Hypoxia inducible factor signaling modulates susceptibility to mycobacterial infection via a nitric oxide dependent mechanism. PLoS Pathog 9 e1003789 PMID: 24367256
Hervera et al (2011) Peripheral effects of mor. and expression of μ-opioid receptors in the dorsal root ganglia during neuropathic pain: nitric oxide signaling. Mol Pain 7 25 PMID: 21486477
Do you know of a great paper that uses L-NIL hydrochloride from Tocris? Please let us know.
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Literature in this Area
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