L-NAME hydrochloride

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Cat.No. 0665 - L-NAME hydrochloride | C7H15N5O4.HCl | CAS No. 51298-62-5
Description: Non-selective NOS inhibitor
Chemical Name: NG-Nitro-L-arginine methyl ester hydrochloride
Purity: ≥98%
Datasheet
Citations (20)
Reviews (1)
Literature

Biological Activity

NO synthase inhibitor.

Compound Libraries

L-NAME hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 269.69
Formula C7H15N5O4.HCl
Storage Store at RT
Purity ≥98%
CAS Number 51298-62-5
PubChem ID 135193
InChI Key QBNXAGZYLSRPJK-JEDNCBNOSA-N
Smiles N=C(NCCC[C@H](N)C(OC)=O)N[N+]([O-])=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 26.97 100
DMSO 26.97 100

Preparing Stock Solutions

The following data is based on the product molecular weight 269.69. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.71 mL 18.54 mL 37.08 mL
5 mM 0.74 mL 3.71 mL 7.42 mL
10 mM 0.37 mL 1.85 mL 3.71 mL
50 mM 0.07 mL 0.37 mL 0.74 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Knowles et al (1994) Nitric oxide synthases in mammals. Biochem.J. 298 249 PMID: 7510950

Moore and Handy (1997) Selective inhibitors of neuronal nitric oxide synthase - is no NOS really good NOS for the nervous system? TiPS 18 204 PMID: 9226999

Pfeiffer et al (1996) Inhibition of nitric oxide synthesis by NG-nitro-L-arginine methyl ester (L-NAME): requirement for bioactivation to the free acid, NG-nitro-L-arginine. Br.J.Pharmacol. 118 1433 PMID: 8832069


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Keywords: L-NAME hydrochloride, L-NAME hydrochloride supplier, Non-Selective, NOS, inhibitors, inhibits, Nitric, Oxide, Signaling, Signalling, Synthase, NO, Synthases, iNOS, eNOS, nNOS, Non-selective, 0665, Tocris Bioscience

20 Citations for L-NAME hydrochloride

Citations are publications that use Tocris products. Selected citations for L-NAME hydrochloride include:

Bucher et al (2014) Medullary NE neurons modulate local oxygen concentrations in the bed nucleus of the stria terminalis. J Cereb Blood Flow Metab 34 1128 PMID: 24714037

Bice et al (2014) NO-independent stimulation or activation of soluble guanylyl cyclase during early reperfusion limits infarct size. Cardiovasc Res 101 220 PMID: 24259501

Elks et al (2013) Hypoxia inducible factor signaling modulates susceptibility to mycobacterial infection via a nitric oxide dependent mechanism. PLoS Pathog 9 e1003789 PMID: 24367256

Orru et al (2013) Psychostimulant pharmacological profile of paraxanthine, the main metabolite of caffeine in humans. Neuropharmacology 67 476 PMID: 23261866

Gross et al (2013) Roles of endothelial nitric oxide synthase (eNOS) and mitochondrial permeability transition pore (MPTP) in epoxyeicosatrienoic acid (EET)-induced cardioprotection against infarction in intact rat hearts. J Mol Cell Cardiol 59 20 PMID: 23419451

Gibson et al (2008) TRPV1 channels mediate long-term depression at synapses on hippocampal interneurons. Neuron 57 746 PMID: 18341994

Gallo and Iadecola (2011) Neuronal nitric oxide contributes to neuroplasticity-associated protein expression through cGMP, protein kinase G, and extracellular signal-regulated kinase. J Neurosci 31 6947 PMID: 21562256

Dai et al (2011) Lactate dilates cochlear capillaries via type V fibrocyte-vessel coupling signaled by nNOS. Am J Physiol Heart Circ Physiol 301 H1248 PMID: 21856924

Silva et al (2007) Melatonin inhibits nitric oxide production by microvascular endothelial cells in vivo and in vitro. Br J Pharmacol 151 195 PMID: 17375079

Cramer et al (2015) Abnormal excitability and episodic low-frequency oscillations in the cerebral cortex of the tottering mouse. Proc Natl Acad Sci U S A 35 5664 PMID: 25855180

Townsend and Emala (2013) Quercetin acutely relaxes airway smooth muscle and potentiates β-agonist-induced relaxation via dual phosphodiesterase inhibition of PLCβ and PDE4. Am J Physiol Lung Cell Mol Physiol 305 L396 PMID: 23873842

Vaish and Singh (2013) Antioxidant Functions of Nitric Oxide Synthase in a Methicillin Sensitive Staphylococcus aureus. Br J Cancer 2013 312146 PMID: 23690783

Huang and Hsu (2010) Activation of muscarinic acetylcholine receptors induces a nitric oxide-dependent long-term depression in rat medial prefrontal cortex. Cereb Cortex 20 982 PMID: 19666830

Pearson et al (2009) Detection of EETs and HETE-generating cytochrome P-450 enzymes and the effects of their metabolites on myometrial and vascular function. Am J Physiol Endocrinol Metab 297 E647 PMID: 19549792

Safo and Regehr (2005) Endocannabinoids control the induction of cerebellar LTD. Neuron 48 647 PMID: 16301180

Chen et al (2002) Development of a human neuronal cell model for human immunodeficiency virus (HIV)-infected macrophage-induced neurotoxicity: apoptosis induced by HIV type 1 primary isolates and evidence for involvement of the Bcl-2/Bcl-xL-sensitive intrinsic apoptosis pa J Virol 76 9407 PMID: 12186923

Cameron (2017) Structural and pharmacological basis for the induction of mitochondrial biogenesis by formo. but not clenbu. Sci Rep 7 10578 PMID: 28874749

Lou et al (2009) Hydroxyurea generates nitric oxide in human erythroid cells: mechanisms for gamma-globin gene activation. Exp Biol Med (Maywood) 234 1374 PMID: 19657070

Casado et al (2000) Presynaptic N-MthD.-aspartate receptors at the parallel fiber-Purkinje cell synapse. Int J Microbiol 97 11593 PMID: 11016958

Sunters et al (2010) Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of Ins-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 receptor-i J Biol Chem 285 8743 PMID: 20042609


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Reviews for L-NAME hydrochloride

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Effective nitric oxide synthase blocker.
By Karthik krishnamurthy on 10/26/2018
Species: Rat
Cell Line/Tissue: astrocytes

Measured time lapse production of nitric oxide in astrocytes stimulated with 30 μM UTP with and without pretreatment with 100 μM L-NAME.

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