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Description: Tryptophan catabolite; endogenous aryl hydrocarbon receptor ligand
Chemical Name: L-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid
Purity: ≥98% (HPLC)
Citations (1)
Reviews (1)

Biological Activity for L-Kynurenine

L-Kynurenine is a tryptophan catabolite; endogenous activator of the aryl hydrocarbon receptor (AhR). Immunosuppressant; suppresses allogeneic T cell proliferation.

Technical Data for L-Kynurenine

M. Wt 208.21
Formula C10H12N2O3
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 2922-83-0
PubChem ID 161166
Smiles O=C(C[C@H](N)C(O)=O)C1=C(N)C=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for L-Kynurenine

Solvent Max Conc. mg/mL Max Conc. mM
water 2.08 10
DMSO 2.08 10

Preparing Stock Solutions for L-Kynurenine

The following data is based on the product molecular weight 208.21. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 48.03 mL 240.14 mL 480.28 mL
0.5 mM 9.61 mL 48.03 mL 96.06 mL
1 mM 4.8 mL 24.01 mL 48.03 mL
5 mM 0.96 mL 4.8 mL 9.61 mL

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Product Datasheets for L-Kynurenine

Certificate of Analysis / Product Datasheet
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References for L-Kynurenine

References are publications that support the biological activity of the product.

Opitz et al (2011) An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor. Nature 478 197 PMID: 21976023

If you know of a relevant reference for L-Kynurenine, please let us know.

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View all Aryl Hydrocarbon Receptor Ligands

Keywords: L-Kynurenine, L-Kynurenine supplier, Kynurenine, tryptophan, catabolite, aryl, hydrocarbon, receptor, ligand, endogenous, AHR, ligands, tryptophan-2,3-dioxygenase, TDO, Kyn, Aryl, Hydrocarbon, Receptors, Tryptophan, 2,3, dioxygenase, 4393, Tocris Bioscience

1 Citation for L-Kynurenine

Citations are publications that use Tocris products. Selected citations for L-Kynurenine include:

Bassel F et al (2020) Correlation Patterns Among B7 Family Ligands and Tryptophan Degrading Enzymes in Hepatocellular Carcinoma. Front Oncol 10 1632 PMID: 33014820

Do you know of a great paper that uses L-Kynurenine from Tocris? Please let us know.

Reviews for L-Kynurenine

Average Rating: 5 (Based on 1 Review.)

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IDO assay standard (L-Kynurenine).
By Debanjan Mukhopadhyay on 01/11/2018
Assay Type: Ex Vivo
Species: Human
Cell Line/Tissue: Human foreskin fibroblast

I use this product as a standard for Indoleamine 2,3 dioxygenase assay. This product worked excellent as a standard for Tryptophan catabolism assay.

This product is very pure and you can use it from a range of 5 uM to 1500 uM.