L-Kynurenine

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Cat.No. 4393 - L-Kynurenine | C10H12N2O3 | CAS No. 2922-83-0
Description: Tryptophan catabolite; endogenous aryl hydrocarbon receptor ligand
Chemical Name: L-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews (2)
Literature

Biological Activity

Tryptophan catabolite; endogenous activator of the aryl hydrocarbon receptor (AhR). Immunosuppressant; suppresses allogeneic T cell proliferation.

Technical Data

M. Wt 208.21
Formula C10H12N2O3
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 2922-83-0
PubChem ID 161166
InChI Key YGPSJZOEDVAXAB-QMMMGPOBSA-N
Smiles O=C(C[C@H](N)C(O)=O)C1=C(N)C=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 2.08 10
DMSO 2.08 10

Preparing Stock Solutions

The following data is based on the product molecular weight 208.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 48.03 mL 240.14 mL 480.28 mL
0.5 mM 9.61 mL 48.03 mL 96.06 mL
1 mM 4.8 mL 24.01 mL 48.03 mL
5 mM 0.96 mL 4.8 mL 9.61 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Opitz et al (2011) An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor. Nature 478 197 PMID: 21976023


If you know of a relevant reference for L-Kynurenine, please let us know.

View Related Products by Product Action

View all Aryl Hydrocarbon Receptor Ligands

Keywords: L-Kynurenine, L-Kynurenine supplier, Kynurenine, tryptophan, catabolite, aryl, hydrocarbon, receptor, ligand, endogenous, AHR, ligands, tryptophan-2,3-dioxygenase, TDO, Kyn, Aryl, Hydrocarbon, Receptors, 4393, Tocris Bioscience

Citations for L-Kynurenine

Citations are publications that use Tocris products.

Currently there are no citations for L-Kynurenine. Do you know of a great paper that uses L-Kynurenine from Tocris? Please let us know.

Reviews for L-Kynurenine

Average Rating: 5 (Based on 2 Reviews.)

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Happy with purchase
By Anonymous on 08/20/2018
Assay Type: In Vitro
Species: Human

Compound was clean and active in cell based assays. Dissolved in DMSO or HCL.


IDO assay standard (L-Kynurenine)
By Debanjan Mukhopadhyay on 01/11/2018
Assay Type: Ex Vivo
Species: Human
Cell Line/Tissue: Human foreskin fibroblast

I use this product as a standard for Indoleamine 2,3 dioxygenase assay. This product worked excellent as a standard for Tryptophan catabolism assay.

This product is very pure and you can use it from a range of 5 uM to 1500 uM.


Literature in this Area

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