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Submit ReviewL-Kynurenine
Description: Tryptophan catabolite; endogenous aryl hydrocarbon receptor ligand
Chemical Name: L-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid
Purity: ≥98% (HPLC)
Biological Activity for L-Kynurenine
L-Kynurenine is a tryptophan catabolite; endogenous activator of the aryl hydrocarbon receptor (AhR). Immunosuppressant; suppresses allogeneic T cell proliferation.
Technical Data for L-Kynurenine
| M. Wt | 208.21 |
| Formula | C10H12N2O3 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 2922-83-0 |
| PubChem ID | 161166 |
| InChI Key | YGPSJZOEDVAXAB-QMMMGPOBSA-N |
| Smiles | O=C(C[C@H](N)C(O)=O)C1=C(N)C=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for L-Kynurenine
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 2.08 | 10 | |
| DMSO | 2.08 | 10 |
Preparing Stock Solutions for L-Kynurenine
The following data is based on the product molecular weight 208.21. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 48.03 mL | 240.14 mL | 480.28 mL |
| 0.5 mM | 9.61 mL | 48.03 mL | 96.06 mL |
| 1 mM | 4.8 mL | 24.01 mL | 48.03 mL |
| 5 mM | 0.96 mL | 4.8 mL | 9.61 mL |
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Product Datasheets for L-Kynurenine
References for L-Kynurenine
References are publications that support the biological activity of the product.
Opitz et al (2011) An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor. Nature 478 197 PMID: 21976023
If you know of a relevant reference for L-Kynurenine, please let us know.
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Keywords: L-Kynurenine, L-Kynurenine supplier, Kynurenine, tryptophan, catabolite, aryl, hydrocarbon, receptor, ligand, endogenous, AHR, ligands, tryptophan-2,3-dioxygenase, TDO, Kyn, Aryl, Hydrocarbon, Receptors, Tryptophan, 2,3, dioxygenase, 4393, Tocris Bioscience
Citations for L-Kynurenine
Citations are publications that use Tocris products.
Currently there are no citations for L-Kynurenine. Do you know of a great paper that uses L-Kynurenine from Tocris? Please let us know.
Reviews for L-Kynurenine
Average Rating: 5 (Based on 1 Review.)
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IDO assay standard (L-Kynurenine).
By
Debanjan Mukhopadhyay on 01/11/2018
Assay Type: Ex Vivo
Species: Human
Cell Line/Tissue: Human foreskin fibroblast
I use this product as a standard for Indoleamine 2,3 dioxygenase assay. This product worked excellent as a standard for Tryptophan catabolism assay.
This product is very pure and you can use it from a range of 5 uM to 1500 uM.
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