Oxidized form of L-Ascorbic acid (Cat. No. 4055). Transported into cells through GLUT1. Selectively induces cell death in KRAS and BRAF mutant cells in vitro.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|water||1.74||10mM with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 174.11. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||5.74 mL||28.72 mL||57.43 mL|
|5 mM||1.15 mL||5.74 mL||11.49 mL|
|10 mM||0.57 mL||2.87 mL||5.74 mL|
|50 mM||0.11 mL||0.57 mL||1.15 mL|
References are publications that support the products' biological activity.
Kaiser (2015) Vitamin C could target some common cancers. Science 6 6261 PMID: 26542550
Yun et al (2015) Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH. Science 11 6266 PMID: 26541605
If you know of a relevant reference for L-Dehydroascorbic acid, please let us know.
Keywords: L-Dehydroascorbic acid, supplier, vitamin, vit, C, oxidised, form, L-Ascorbic, acid, GLUT1, glucose, transporters, KRAS, BRAF, Glucose, Transporters, Antioxidants, Glucose, Transporters, Tocris Bioscience
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