L-Dehydroascorbic acid

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Cat.No. 5734 - L-Dehydroascorbic acid | C6H6O6 | CAS No. 490-83-5
Description: GLUT1 substrate; oxidized form of L-Ascorbic acid
Chemical Name: L-threo-2,3-Hexodiulosonic acid γ-lactone
Literature (1)

Biological Activity for L-Dehydroascorbic acid

L-Dehydroascorbic acid is a oxidized form of L-Ascorbic acid (Cat. No. 4055). Transported into cells through GLUT1. Selectively induces cell death in KRAS and BRAF mutant cells in vitro.

Technical Data for L-Dehydroascorbic acid

M. Wt 174.11
Formula C6H6O6
Storage Store at -20°C
CAS Number 490-83-5
PubChem ID 440667
Smiles O=C1C([C@]([C@@H](O)CO)([H])OC1=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for L-Dehydroascorbic acid

Solvent Max Conc. mg/mL Max Conc. mM
water 1.74 10 with gentle warming
DMSO 17.41 100

Preparing Stock Solutions for L-Dehydroascorbic acid

The following data is based on the product molecular weight 174.11. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.74 mL 28.72 mL 57.43 mL
5 mM 1.15 mL 5.74 mL 11.49 mL
10 mM 0.57 mL 2.87 mL 5.74 mL
50 mM 0.11 mL 0.57 mL 1.15 mL

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Product Datasheets for L-Dehydroascorbic acid

References for L-Dehydroascorbic acid

References are publications that support the biological activity of the product.

Kaiser (2015) Vitamin C could target some common cancers. Science 6 6261 PMID: 26542550

Yun et al (2015) Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH. Science 11 6266 PMID: 26541605

If you know of a relevant reference for L-Dehydroascorbic acid, please let us know.

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Keywords: L-Dehydroascorbic acid, L-Dehydroascorbic acid supplier, vitamin, vit, C, oxidised, form, L-Ascorbic, acid, GLUT1, glucose, transporters, KRAS, BRAF, Glucose, Transporters, Antioxidants, 5734, Tocris Bioscience

Citations for L-Dehydroascorbic acid

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