L-Dehydroascorbic acid

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Cat.No. 5734 - L-Dehydroascorbic acid | C6H6O6 | CAS No. 490-83-5
Description: GLUT1 substrate; oxidized form of L-Ascorbic acid
Chemical Name: L-threo-2,3-Hexodiulosonic acid γ-lactone

Biological Activity

Oxidized form of L-Ascorbic acid (Cat. No. 4055). Transported into cells through GLUT1. Selectively induces cell death in KRAS and BRAF mutant cells in vitro.

Technical Data

M. Wt 174.11
Formula C6H6O6
Storage Store at -20°C
CAS Number 490-83-5
PubChem ID 440667
Smiles O=C1C([C@]([C@@H](O)CO)([H])OC1=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 17.41 100
water 1.74 10mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 174.11. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.74 mL 28.72 mL 57.43 mL
5 mM 1.15 mL 5.74 mL 11.49 mL
10 mM 0.57 mL 2.87 mL 5.74 mL
50 mM 0.11 mL 0.57 mL 1.15 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Kaiser (2015) Vitamin C could target some common cancers. Science 6 6261 PMID: 26542550

Yun et al (2015) Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH. Science 11 6266 PMID: 26541605

If you know of a relevant reference for L-Dehydroascorbic acid, please let us know.

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Cancer Research Product Guide

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