L-703,664 succinate

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Cat.No. 2640 - L-703,664 succinate | C16H24N4O2S.C4H6O4 | CAS No. 144776-01-2
Description: Selective 5-HT1D receptor agonist
Chemical Name: N,N-Dimethyl-5-[(5-methyl-1,1-dioxodo-1,2,5-thiadiazolidin-2-yl)methyl]-1H-indole-3-ethanamine succinate
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

5-HT1D receptor agonist that displays selectivity over other 5-HT receptor subtypes (pIC50 values are 7.2, 6.1, < 5.0 and < 5.0 for 5-HT1D, 5-HT1A, 5-HT2A and 5-HT3 respectively) and other receptors (pIC50 < 5.0 for adenosine, adrenergic, excitatory amino acids, dopamine, histamine, muscarinic, nicotinic and opiate receptors).

Licensing Information

Sold with the permission of Merck, Sharpe and Dohme Ltd.

Technical Data

M. Wt 454.54
Formula C16H24N4O2S.C4H6O4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 144776-01-2
PubChem ID 90488774
InChI Key WLXRLNXDMGIORD-UHFFFAOYSA-N
Smiles O=S1(N(CCN1C)CC2=CC=C(NC=C3CCN(C)C)C3=C2)=O.O=C(CCC(O)=O)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 45.45 100
water 22.73 50

Preparing Stock Solutions

The following data is based on the product molecular weight 454.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.2 mL 11 mL 22 mL
5 mM 0.44 mL 2.2 mL 4.4 mL
10 mM 0.22 mL 1.1 mL 2.2 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Castro et al (1994) Synthesis and biological activity of 3-[2-(dimethylamino)ethyl]-5-[(1,1-dioxo-5-methyl-1,2,5-thiadiazolidin-2-yl)-methyl]-1H-indole and analogues: agonists for the 5-HT1D receptor. J.Med.Chem. 37 3023 PMID: 7932524


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Keywords: Selective 5-HT1D receptor agonists Serotonin Receptors L703664 5-HT1D Receptors

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GPCR

GPCR Product Listing

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5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

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