L-703,664 succinate

Pricing Availability   Qty
Cat.No. 2640 - L-703,664 succinate | C16H24N4O2S.C4H6O4 | CAS No. 144776-01-2
Description: Selective 5-HT1D receptor agonist
Chemical Name: N,N-Dimethyl-5-[(5-methyl-1,1-dioxodo-1,2,5-thiadiazolidin-2-yl)methyl]-1H-indole-3-ethanamine succinate
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

5-HT1D receptor agonist that displays selectivity over other 5-HT receptor subtypes (pIC50 values are 7.2, 6.1, < 5.0 and < 5.0 for 5-HT1D, 5-HT1A, 5-HT2A and 5-HT3 respectively) and other receptors (pIC50 < 5.0 for adenosine, adrenergic, excitatory amino acids, dopamine, histamine, muscarinic, nicotinic and opiate receptors).

Licensing Information

Sold with the permission of Merck, Sharpe and Dohme Ltd.

Technical Data

M. Wt 454.54
Formula C16H24N4O2S.C4H6O4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 144776-01-2
PubChem ID 90488774
InChI Key WLXRLNXDMGIORD-UHFFFAOYSA-N
Smiles O=S1(N(CCN1C)CC2=CC=C(NC=C3CCN(C)C)C3=C2)=O.O=C(CCC(O)=O)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 22.73 50
DMSO 45.45 100

Preparing Stock Solutions

The following data is based on the product molecular weight 454.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.2 mL 11 mL 22 mL
5 mM 0.44 mL 2.2 mL 4.4 mL
10 mM 0.22 mL 1.1 mL 2.2 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References

References are publications that support the biological activity of the product.

Castro et al (1994) Synthesis and biological activity of 3-[2-(dimethylamino)ethyl]-5-[(1,1-dioxo-5-methyl-1,2,5-thiadiazolidin-2-yl)-methyl]-1H-indole and analogues: agonists for the 5-HT1D receptor. J.Med.Chem. 37 3023 PMID: 7932524


If you know of a relevant reference for L-703,664 succinate, please let us know.

View Related Products by Target

View Related Products by Product Action

View all 5-HT1D Receptor Agonists

Keywords: L-703,664 succinate, L-703,664 succinate supplier, Selective, 5-HT1D, receptor, agonists, Serotonin, Receptors, L703664, 2640, Tocris Bioscience

Citations for L-703,664 succinate

Citations are publications that use Tocris products.

Currently there are no citations for L-703,664 succinate. Do you know of a great paper that uses L-703,664 succinate from Tocris? Please let us know.

Reviews for L-703,664 succinate

There are currently no reviews for this product. Be the first to review L-703,664 succinate and earn rewards!

Have you used L-703,664 succinate?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.