Discontinued Product

Unfortunately L-695,845 (Cat. No. 0473) has been withdrawn from sale for commercial reasons.
Cat.No. 0473 - L-695,845 | CAS No. 137730-58-6
Description: High affinity s ligand
Chemical Name: 3,4-Dihydro-1'-(3-methylbut-2-enyl)spiro[1H-indene-1,4'-piperidine]

Biological Activity

High affinity σ ligand with 10000-fold preference for theσ binding site over the dopamine D2 receptor.

Licensing Information

Sold with the permission of Merck Sharp & Dohme Ltd.

Technical Data

M. Wt 255.4
Storage Desiccate at -20°C
CAS Number 137730-58-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 255.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.92 mL 19.58 mL 39.15 mL
5 mM 0.78 mL 3.92 mL 7.83 mL
10 mM 0.39 mL 1.96 mL 3.92 mL
50 mM 0.08 mL 0.39 mL 0.78 mL

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Product Datasheets

Certificate of Analysis is currently unavailable
on-line. Please contact Customer Service
Safety Datasheet


References are publications that support the products' biological activity.

Chambers et al (1992) Spiropiperidines as high affinity, selective σ ligands. J.Med.Chem. 35 2033 PMID: 1317923

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