L-694,247

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Cat.No. 0781 - L-694,247 | C20H21N5O3S | CAS No. 137403-12-4
Description: 5-HT1D agonist
Chemical Name: 2-[5-[3-(4-Methylsulfonylamino)benzyl-1,2,4-oxadiazol-5-yl]-1H-indol-3-yl]ethanamine
Purity: ≥98% (HPLC)
Datasheet
Citations (3)
Reviews
Literature

Biological Activity

Selective and extremely potent 5-HT1D receptor agonist.

Licensing Information

Sold with the permission of Merck Sharp and Dohme Ltd.

Technical Data

M. Wt 411.48
Formula C20H21N5O3S
Storage Desiccate at +4°C
Purity ≥98% (HPLC)
CAS Number 137403-12-4
PubChem ID 132059
InChI Key HKXMQLISPYELRD-UHFFFAOYSA-N
Smiles CS(=O)(=O)NC1=CC=C(CC2=NOC(=N2)C2=CC=C3NC=C(CCN)C3=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 100 mM in DMSO

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Beer et al (1993) L-694,247: a potent 5-HT1D receptor agonist. Br.J.Pharmacol. 110 1196 PMID: 8298808

Buhlen et al (1996) Evidence for presynaptic location of inhibitory 5-HT1Dβ -like autoreceptors in the guinea-pig brain cortex. Naunyn Schmiedebergs Arch.Pharmacol. 353 281 PMID: 8692282

Heald et al (1994) [3H]L-694,247 labels the 5-HT1Dβ receptor in pig caudate membranes. Eur.J.Pharmacol. 264 213 PMID: 7851485

Street et al (1993) Synthesis and serotonergic activity of 5-(oxadiazoyl)tryptamines: potent agonists of 5-HT1D receptors. J.Med.Chem. 36 1529 PMID: 8496922


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Keywords: L-694,247, L-694,247 supplier, 5-HT1D, agonists, Serotonin, Receptors, L694247, merck, 0781, Tocris Bioscience

3 Citations for L-694,247

Citations are publications that use Tocris products. Selected citations for L-694,247 include:

Bhalla et al (2001) Molecular cloning, pharmacological properties and tissue distribution of the porcine 5-HT(1B) receptor. Br J Pharmacol 133 891 PMID: 11454663

Geerts et al (1999) Involvement of 5-HT1B receptors in collar-induced hypersensitivity to 5-hydroxytryptamine of the rabbit carotid artery. Br J Pharmacol 127 1327 PMID: 10455282

Hampson et al (2007) Stimulation of glycogen synthesis and inactivation of phosphorylase in hepatocytes by serotonergic mechanisms, and counter-regulation by atypical antipsychotic drugs. Diabetologia 50 1743 PMID: 17579833


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Literature in this Area

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5-HT Receptors Scientific Review

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