Selective and extremely potent 5-HT1D receptor agonist.
Sold with the permission of Merck Sharp and Dohme Ltd.
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 100 mM in DMSO|
Preparing Stock Solutions
The following data is based on the product molecular weight 411.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.43 mL||12.15 mL||24.3 mL|
|5 mM||0.49 mL||2.43 mL||4.86 mL|
|10 mM||0.24 mL||1.22 mL||2.43 mL|
|50 mM||0.05 mL||0.24 mL||0.49 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Beer et al (1993) L-694,247: a potent 5-HT1D receptor agonist. Br.J.Pharmacol. 110 1196 PMID: 8298808
Buhlen et al (1996) Evidence for presynaptic location of inhibitory 5-HT1Dβ -like autoreceptors in the guinea-pig brain cortex. Naunyn Schmiedebergs Arch.Pharmacol. 353 281 PMID: 8692282
Heald et al (1994) [3H]L-694,247 labels the 5-HT1Dβ receptor in pig caudate membranes. Eur.J.Pharmacol. 264 213 PMID: 7851485
Street et al (1993) Synthesis and serotonergic activity of 5-(oxadiazoyl)tryptamines: potent agonists of 5-HT1D receptors. J.Med.Chem. 36 1529 PMID: 8496922
If you know of a relevant reference for L-694,247, please let us know.
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Keywords: 5-HT1D agonists Serotonin Receptors L694247 merck 5-HT1D Receptors
1 Citation for L-694,247
Citations are publications that use Tocris products. Selected citations for L-694,247 include:
Bhalla et al (2001) Molecular cloning, pharmacological properties and tissue distribution of the porcine 5-HT(1B) receptor. Br J Pharmacol 133 891 PMID: 11454663
Do you know of a great paper that uses L-694,247 from Tocris? If so please let us know.
Literature in this Area
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.