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Cat.No. 0781 - L-694,247 | C20H21N5O3S | CAS No. 137403-12-4
Description: 5-HT1D agonist
Chemical Name: 2-[5-[3-(4-Methylsulfonylamino)benzyl-1,2,4-oxadiazol-5-yl]-1H-indol-3-yl]ethanamine
Purity: ≥98% (HPLC)
Citations (1)

Biological Activity

Selective and extremely potent 5-HT1D receptor agonist.

Licensing Information

Sold with the permission of Merck Sharp and Dohme Ltd.

Technical Data

M. Wt 411.48
Formula C20H21N5O3S
Storage Desiccate at +4°C
Purity ≥98% (HPLC)
CAS Number 137403-12-4
PubChem ID 132059
Smiles CS(=O)(=O)NC1=CC=C(CC2=NOC(=N2)C2=CC=C3NC=C(CCN)C3=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in DMSO

Preparing Stock Solutions

The following data is based on the product molecular weight 411.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.43 mL 12.15 mL 24.3 mL
5 mM 0.49 mL 2.43 mL 4.86 mL
10 mM 0.24 mL 1.22 mL 2.43 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet


References are publications that support the products' biological activity.

Beer et al (1993) L-694,247: a potent 5-HT1D receptor agonist. Br.J.Pharmacol. 110 1196 PMID: 8298808

Buhlen et al (1996) Evidence for presynaptic location of inhibitory 5-HT1Dβ -like autoreceptors in the guinea-pig brain cortex. Naunyn Schmiedebergs Arch.Pharmacol. 353 281 PMID: 8692282

Heald et al (1994) [3H]L-694,247 labels the 5-HT1Dβ receptor in pig caudate membranes. Eur.J.Pharmacol. 264 213 PMID: 7851485

Street et al (1993) Synthesis and serotonergic activity of 5-(oxadiazoyl)tryptamines: potent agonists of 5-HT1D receptors. J.Med.Chem. 36 1529 PMID: 8496922

If you know of a relevant reference for L-694,247, please let us know.

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Keywords: L-694,247, supplier, 5-HT1D, agonists, Serotonin, Receptors, L694247, merck, 5-HT1D, Receptors, 5-HT1D, Receptors, Tocris Bioscience

1 Citation for L-694,247

Citations are publications that use Tocris products. Selected citations for L-694,247 include:

Bhalla et al (2001) Molecular cloning, pharmacological properties and tissue distribution of the porcine 5-HT(1B) receptor. Br J Pharmacol 133 891 PMID: 11454663

Do you know of a great paper that uses L-694,247 from Tocris? If so please let us know.

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